Phenylpiperazin-ethyl-oxo-thia-diaza-hexahydrofluorenecarbothioate-Cpd6b
6b AChE IC50 = 0.07 +/- 0.003 microM; BuChE IC50 0.059 +/- 0.004 microM
General
Type : Piperazine, Sulfur Compound, Carbamate, Thiocarbamate
Chemical_Nomenclature : C-4-phenylpiperazin-1-yl 3-ethyl-4-oxo-9-thia-1,3-diaza-3,4,5,6,7,8-hexahydrofluorene-2-carbothioate
Canonical SMILES : C13=C(SC2=C1CCCC2)N=C(N(C3=O)CC)SC(N4CCN(CC4)C5=CC=CC=C5)=O
InChI : InChI=1S\/C23H26N4O2S2\/c1-2-27-21(28)19-17-10-6-7-11-18(17)30-20(19)24-22(27)31-23(29)26-14-12-25(13-15-26)16-8-4-3-5-9-16\/h3-5,8-9H,2,6-7,10-15H2,1H3
InChIKey : FNNDSXMXWSZCMC-UHFFFAOYSA-N
Other name(s) : Compound 6b || C-4-Phenyl-1-piperazinyl 3-ethyl-4-oxo-9-thia-1,3-diaza-3,4,5,6,7,8-hexahydro-2-fluorenecarbothioate
Target
Families : Phenylpiperazin-ethyl-oxo-thia-diaza-hexahydrofluorenecarbothioate-Cpd6b ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease - Eissa_2023_Drug.Dev.Res__ |
| Author(s) : Eissa KI , Kamel MM , Mohamed LW , Doghish AS , Alnajjar R , Al-Karmalawy AA , Kassab AE |
| Ref : Drug Dev Res , : , 2023 |
| Abstract : |
| PubMedSearch : Eissa_2023_Drug.Dev.Res__ |
| PubMedID: 37067008 |