QTC-4-MeOBnE
General
Type : Multitarget, BACE1-inhibitor, Triazol, Derivative of Tacrine
Chemical_Nomenclature :
Canonical SMILES : C1=C(C=C2C(=C1)C(=CC=N2)[N]3C(=C(N=N3)C(NCC4=CC=C(C=C4)OC)=O)C)Cl
InChI : InChI=1S\/C21H18ClN5O2\/c1-13-20(21(28)24-12-14-3-6-16(29-2)7-4-14)25-26-27(13)19-9-10-23-18-11-15(22)5-8-17(18)19\/h3-11H,12H2,1-2H3,(H,24,28)
InChIKey : SVJJXBAHZZVFPI-UHFFFAOYSA-N
Other name(s) :
Target
Families : QTC-4-MeOBnE ligand of proteins in family
ACHE
References (4)
| Title : 1-(7-Chloroquinolin-4-yl)-N-(4-Methoxybenzyl)-5-Methyl-1H-1,2, 3-Triazole-4- carboxamide Reduces Abeta Formation and Tau Phosphorylation in Cellular Models of Alzheimer's Disease - Fronza_2022_Neurochem.Res__ |
| Author(s) : Fronza MG , Sacramento M , Alves D , Pratico D , Savegnago L |
| Ref : Neurochem Res , : , 2022 |
| Abstract : |
| PubMedSearch : Fronza_2022_Neurochem.Res__ |
| PubMedID: 35165799 |
| Title : Effect of QTC-4-MeOBnE Treatment on Memory, Neurodegeneration, and Neurogenesis in a Streptozotocin-Induced Mouse Model of Alzheimer's Disease - Fronza_2021_ACS.Chem.Neurosci_12_109 |
| Author(s) : Fronza MG , Baldinotti R , Sacramento M , Gutierres J , Carvalho FB , Fernandes MDC , Sousa FSS , Seixas FK , Collares T , Alves D , Pratico D , Savegnago L |
| Ref : ACS Chem Neurosci , 12 :109 , 2021 |
| Abstract : |
| PubMedSearch : Fronza_2021_ACS.Chem.Neurosci_12_109 |
| PubMedID: 33315382 |
| Title : QTC-4-MeOBnE rescues scopolamine-induced memory deficits in mice by targeting oxidative stress, neuronal plasticity and apoptosis - Fronza_2020_ACS.Chem.Neurosci_11_1259 |
| Author(s) : Fronza MG , Baldinotti R , Fetter J , Sacramento M , Sousa FSS , Seixas FK , Collares T , Alves D , Pratico D , Savegnago L |
| Ref : ACS Chem Neurosci , 11 :1259 , 2020 |
| Abstract : |
| PubMedSearch : Fronza_2020_ACS.Chem.Neurosci_11_1259 |
| PubMedID: 32227985 |
| Title : Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer's disease - Fronza_2019_Sci.Rep_9_7276 |
| Author(s) : Fronza MG , Baldinotti R , Martins MC , Goldani B , Dalberto BT , Kremer FS , Begnini K , Pinto LDS , Lenardao EJ , Seixas FK , Collares T , Alves D , Savegnago L |
| Ref : Sci Rep , 9 :7276 , 2019 |
| Abstract : |
| PubMedSearch : Fronza_2019_Sci.Rep_9_7276 |
| PubMedID: 31086208 |