Quinoline-Coulmarin-CpdB8
IC50 microM AChE >5(20.8 %) BChE 0.15 +/- 0.0
General
Type : Quinoline, Coumarin, Chromen, Multitarget
Chemical_Nomenclature : 4-((5-(Quinolin-8-yloxy) pentyl) oxy)-2H-chromen-2-one
Canonical SMILES : C1(=CC(OC2=C1C=CC=C2)=O)OCCCCCOC3=CC=CC4=C3N=CC=C4
InChI : InChI=1S\/C23H21NO4\/c25-22-16-21(18-10-2-3-11-19(18)28-22)27-15-5-1-4-14-26-20-12-6-8-17-9-7-13-24-23(17)20\/h2-3,6-13,16H,1,4-5,14-15H2
InChIKey : ZJUXIVWJIIKFES-UHFFFAOYSA-N
Other name(s) : Compound B8
Target
Families : Quinoline-Coulmarin-CpdB8 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Discovery of novel hybrids of coumarin and quinoline as potential anti-Alzheimer's disease agent - Li_2025_Bioorg.Med.Chem_133_118499 |
| Author(s) : Li S , Li X , Chen D , Xia C |
| Ref : Bioorganic & Medicinal Chemistry , 133 :118499 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Bioorg.Med.Chem_133_118499 |
| PubMedID: 41338169 |