SCHEMBL4415503
AChE (IC50 = 0.24 microM) and BChE (IC50 = 6.29 microM)
General
Type : Trifluoro, Phthalimido, Isoindole, Indole
Chemical_Nomenclature : 2-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]isoindole-1,3-dione
Canonical SMILES : C1=CC=C2C(=C1)C(=O)N(C2=O)CC3=CC=C(C=C3)C4=CC=C(C=C4)C(F)(F)F
InChI : InChI=1S\/C22H14F3NO2\/c23-22(24,25)17-11-9-16(10-12-17)15-7-5-14(6-8-15)13-26-20(27)18-3-1-2-4-19(18)21(26)28\/h1-12H,13H2
InChIKey : DBCOCUPRPXORSW-UHFFFAOYSA-N
Other name(s) :
MW : 381.3
Formula : C22H14F3NO2
CAS_number :
PubChem : 21936271
UniChem : DBCOCUPRPXORSW-UHFFFAOYSA-N
Target
Families : SCHEMBL4415503 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors - Abdullah_2025_ACS.Omega_10_10385 |
| Author(s) : Abdullah N , Hussain F , Ullah N , Fatima H , Tahir MA , Rashid U , Hassan A |
| Ref : ACS Omega , 10 :10385 , 2025 |
| Abstract : |
| PubMedSearch : Abdullah_2025_ACS.Omega_10_10385 |
| PubMedID: 40124046 |
| Title : Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors - Abdullah_2025_ACS.Omega_10_10385 |
| Author(s) : Abdullah N , Hussain F , Ullah N , Fatima H , Tahir MA , Rashid U , Hassan A |
| Ref : ACS Omega , 10 :10385 , 2025 |
| Abstract : |
| PubMedSearch : Abdullah_2025_ACS.Omega_10_10385 |
| PubMedID: 40124046 |
| Title : Synthesis, Pharmacological Evaluation, and Molecular Modeling of Phthalimide Derivatives as Monoamine Oxidase and Cholinesterase Dual Inhibitors - Abdullah_2025_ACS.Omega_10_10385 |
| Author(s) : Abdullah N , Hussain F , Ullah N , Fatima H , Tahir MA , Rashid U , Hassan A |
| Ref : ACS Omega , 10 :10385 , 2025 |
| Abstract : |
| PubMedSearch : Abdullah_2025_ACS.Omega_10_10385 |
| PubMedID: 40124046 |