SR-4559
Directly binds ABHD5 and stimulate lipolysis by releasing it from PLIN, thereby mimicking the effects of extracellular signaling in the absence of PKA-dependent phosphorylation of HSL and PLIN || ABHD5 IC50 2.379 microM relatively good inhibitor
General
Type : Piperazine, Sulfur Compound, Sulfonamide, Benzofuran
Chemical_Nomenclature : 1-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazin-1-yl]-2-(6-methyl-1-benzofuran-3-yl)ethanone
Canonical SMILES : CC1=CC2=C(C=C1)C(=CO2)CC(=O)N3CCN(CC3)S(=O)(=O)C4=CC5=C(C=C4)OCCO5
InChI : InChI=1S\/C23H24N2O6S\/c1-16-2-4-19-17(15-31-21(19)12-16)13-23(26)24-6-8-25(9-7-24)32(27,28)18-3-5-20-22(14-18)30-11-10-29-20\/h2-5,12,14-15H,6-11,13H2,1H3
InChIKey : HJVYLFAPJPGKEE-UHFFFAOYSA-N
Other name(s) : SR-01000604559 || SR4559 || MLS000863888 || SMR000068843 || AC1MBBZL || BDBM94640 || CHEMBL1312711 || ZINC3557087
MW : 456.5
Formula : C23H24N2O6S
CAS_number : 847939-23-5
PubChem : 2674365
UniChem : HJVYLFAPJPGKEE-UHFFFAOYSA-N
Target
Families : SR-4559 ligand of proteins in family
CGI-58_ABHD5_ABHD4
Protein :
human-ABHD5
mouse-abhd5
References (3)
| Title : Molecular Modeling of ABHD5 Structure and Ligand Recognition - Shahoei_2022_Front.Mol.Biosci_9_935375 |
| Author(s) : Shahoei R , Pangeni S , Sanders MA , Zhang H , Mladenovic-Lucas L , Roush WR , Halvorsen G , Kelly CV , Granneman JG , Huang YM |
| Ref : Front Mol Biosci , 9 :935375 , 2022 |
| Abstract : |
| PubMedSearch : Shahoei_2022_Front.Mol.Biosci_9_935375 |
| PubMedID: 35836935 |
| Gene_locus related to this paper: human-ABHD5 , mouse-abhd5 |
| Title : Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes - Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| Author(s) : Rondini EA , Mladenovic-Lucas L , Roush WR , Halvorsen GT , Green AE , Granneman JG |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 363 :367 , 2017 |
| Abstract : |
| PubMedSearch : Rondini_2017_J.Pharmacol.Exp.Ther_363_367 |
| PubMedID: 28928121 |
| Gene_locus related to this paper: human-ABHD5 , mouse-abhd5 |
| Title : Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle - Sanders_2015_Cell.Metab_22_851 |
| Author(s) : Sanders MA , Madoux F , Mladenovic L , Zhang H , Ye X , Angrish M , Mottillo EP , Caruso JA , Halvorsen G , Roush WR , Chase P , Hodder P , Granneman JG |
| Ref : Cell Metab , 22 :851 , 2015 |
| Abstract : |
| PubMedSearch : Sanders_2015_Cell.Metab_22_851 |
| PubMedID: 26411340 |
| Gene_locus related to this paper: human-ABHD5 , mouse-abhd5 |