TAC-Chloro-PhBTA-Cpd15
IC50 ACHE 0.06 microM
General
Type : Derivative of Tacrine, Acridine, Sulfur Compound, Multitarget, Benzothiazol
Chemical_Nomenclature : N-[3-(6-Chloro-1,2,3,4-tetrahydro-9-acridinylamino)propyl][4-(1,3-benzothiazol-2-yl)-2-methoxyphenoxy]acetamide
Canonical SMILES : C1(=C3C(=NC2=C1C=CC(=C2)Cl)CCCC3)NCCCNC(COC4=CC=C(C=C4OC)C5=NC6=C(S5)C=CC=C6)=O
InChI : InChI=1S\/C32H31ClN4O3S\/c1-39-28-17-20(32-37-25-9-4-5-10-29(25)41-32)11-14-27(28)40-19-30(38)34-15-6-16-35-31-22-7-2-3-8-24(22)36-26-18-21(33)12-13-23(26)31\/h4-5,9-14,17-18H,2-3,6-8,15-16,19H2,1H3,(H,34,38)(H,35,36)
InChIKey : UAMIASDANSGYDU-UHFFFAOYSA-N
Other name(s) : Tacrine-2-Phenyl-benzothiazole || Compound 15
Target
Families : TAC-Chloro-PhBTA-Cpd15 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease - Rajeshwari_2019_Molecules_24_587 |
| Author(s) : Rajeshwari R , Chand K , Candeias E , Cardoso SM , Chaves S , Santos MA |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Rajeshwari_2019_Molecules_24_587 |
| PubMedID: 30736397 |