Tacrine-iminosugar-Cpd11b
eeAChE IC50 10.7 +/- 0.3 nM; eqBuChE IC50 8.1 +/- 0.1 nM; eeAChE Ki = 19.0 +/- 1.8 nM; eeAChE Ki = 10.0 +/- 2.7 nM
General
Type : Carbohydrate, Glycoside, Triazol, Derivative of Tacrine, Acridine
Chemical_Nomenclature : N-((1-(2-((1,2,3,4-Tetrahydroacridin-9-yl)amino)hexyl)-1H-1,2,3-triazol-4-yl)methyl)-1,4-dideoxy-1,4-imino-L-arabinitol
Canonical SMILES : C1=CC=CC2=C1N=C5C(=C2NCCCCCC[N]3C=C(N=N3)CN4[C@H]([C@@H]([C@H](C4)O)O)CO)CCCC5
InChI : InChI=1S\/C27H38N6O3\/c34-18-24-27(36)25(35)17-32(24)15-19-16-33(31-30-19)14-8-2-1-7-13-28-26-20-9-3-5-11-22(20)29-23-12-6-4-10-21(23)26\/h3,5,9,11,16,24-25,27,34-36H,1-2,4,6-8,10,12-15,17-18H2,(H,28,29)\/t24-,25-,27-\/m0\/s1
InChIKey : ZJAMOTDXCCHESH-KLJDGLGGSA-N
Other name(s) : Compound 11b
Target
Families : Tacrine-iminosugar-Cpd11b ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers - Vaaland_2023_J.Enzyme.Inhib.Med.Chem_38_349 |
| Author(s) : Vaaland IC , Lopez O , Puerta A , Fernandes MX , Padron JM , Fernandez-Bolanos JG , Sydnes MO , Lindback E |
| Ref : J Enzyme Inhib Med Chem , 38 :349 , 2023 |
| Abstract : |
| PubMedSearch : Vaaland_2023_J.Enzyme.Inhib.Med.Chem_38_349 |
| PubMedID: 36458374 |