Tetrahydrolipstatin-alkyne

General

Type : Oxooxetan, Lipase inhibitor, Alkyne

Chemical_Nomenclature :

Canonical SMILES : CCCCCCCCCCCC(CC1OC(C1CCCCC#C)=O)OC(=O)C(NC(=O)[H])CC(C)C

InChI : InChI=1S\/C29H49NO5\/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2\/h2,22-27H,5,7-21H2,1,3-4H3,(H,30,31)

InChIKey : YHKLBWUOXJBAIG-UHFFFAOYSA-N

Other name(s) : Tetrahydrolipstatin (THL)-alkyne, THL-alkyne, Orlistat-alkyne

MW : 491.71

Formula : C29H49NO5

CAS_number :

PubChem :

UniChem : YHKLBWUOXJBAIG-UHFFFAOYSA-N

Target

Families : Tetrahydrolipstatin-alkyne ligand of proteins in family
Hormone-sensitive_lipase_like

Protein :
myctu-Rv2970c

References (1)

Title : Targeting Lipid Esterases in Mycobacteria Grown Under Different Physiological Conditions Using Activity-based Profiling with Tetrahydrolipstatin (THL) - Ravindran_2014_Mol.Cell.Proteomics_13_435

Author(s) : Ravindran MS , Rao SP , Cheng X , Shukla A , Cazenave-Gassiot A , Yao SQ , Wenk MR

Ref : Mol Cell Proteomics , 13 :435 , 2014

PubMedID: 24345785

Gene_locus related to this paper: myctu-Rv2970c

Tetrahydrolipstatin-alkyne

General

Target

References (1)

1. Targeting Lipid Esterases in Mycobacteria Grown Under Different Physiological Conditions Using Activity-based Profiling with Tetrahydrolipstatin (THL) - Ravindran_2014_Mol.Cell.Proteomics_13_435