Alkyne

General

Alkyne is an unsaturated hydrocarbon containing at least one carboncarbon triple bond. Featuring a reactive functional group, alkynes participate in many organic reactions. But specially usefull when used as substrate of Strain-promoted azide-alkyne cycloaddition (SPAAC) together with azide substrate when both come close in the active site of an enzyme ( 'click reaction') and in 'Staudinger ligation'. lending to combinatorial chemistry.
Inhibitor Main targeted enzyme families Type Structure
Benzylpiperidine-isatin-Cpd15 ACHE Monoamine-oxidase-inhibitor Multitarget Piperidine Benzylpiperidine Isatin Alkyne
CHEMBL4595876 ACHE Multitarget Pyridine Sigma1R ligand Cyanide Alkyne
Contilistat Multitarget Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor Piperidine Indole HDAC inhibitor Alkyne Sulfur Compound Sigma1R ligand
75J-34n DPP4N_Peptidase_S9 Piperidine Imidazole Purine Cyanide Alkyne
JB101 6_AlphaBeta_hydrolase Organophosphate Carbamate Alkyne
JJ-OX-004 6_AlphaBeta_hydrolase Hormone-sensitive_lipase_like Oxadiazolone Oxadiazol Alkyne
Tacrine-selegiline-8g BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand Alkyne
Tacrine-selegiline-7d BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Acridine Derivative of Tacrine Alkyl linked bis-ligand Alkyne
JS0-7ZPB BCHE Quinoline Piperazine Multitarget Monoamine-oxidase-inhibitor Alkyne
WMY90-5f ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil Alkyne Cyanide
DPH6 BCHE ACHE Quinoline Multitarget Monoamine-oxidase-inhibitor Derivative of Donepezil Alkyne Cyanide
AI6-7QBR BCHE Quinoline Piperazine tert-Butyl Multitarget Monoamine-oxidase-inhibitor Alkyne
Propargyl-Tacrine-15 BCHE ACHE Multitarget Monoamine-oxidase-inhibitor Derivative of Tacrine Alkyne
M30D ACHE Monoamine-oxidase-inhibitor Multitarget Carbamate Quinoline Alkyne
Cpd-17-Cycloheptyl-Indole-undecyl-carbamate ACHE BCHE Carbamate Indole Cycloheptyl Derivative of Tryptophan Alkyne
EZ120P A85-Mycolyl-transferase Oxooxetan Lipase inhibitor Alkyne
Tetrahydrolipstatin-alkyne Hormone-sensitive_lipase_like Oxooxetan Lipase inhibitor Alkyne
Lalistat-alkyne-probe Acidic_Lipase 6_AlphaBeta_hydrolase Cutinase Hormone-sensitive_lipase_like Monoglyceridelipase_lysophospholip Piperidine Lipase inhibitor Sulfur Compound Thiadiazol Alkyne ABPP-Probe
alkyne-PEG-FP Organophosphate ABPP-Probe Fluorescent Probe Alkyne
PPOH Pectinacetylesterase-Notum Not AlphaBeta Hydrolase target Alkyne
MT-031 ACHE BCHE Monoamine-oxidase-inhibitor Multitarget Carbamate Alkyne
DH376 Lipase_3 Piperidine Triazol Urea derivative Alkyne
OWW-6YL4 Epoxide_hydrolase Trifluoro Multitarget 5-Lipoxygenase inhibitor Alkyne
75M-5T4F DPP4N_Peptidase_S9 Piperidine Quinazoline Cyanide Purine Alkyne
75L-5T4E DPP4N_Peptidase_S9 Piperidine Pyrimidine Quinazoline Purine Alkyne
75N-5T4B DPP4N_Peptidase_S9 Piperidine Quinazoline Purine Alkyne
Soporidine RsbQ-like Alkyne Piperidine Trifluoro Strigolactone receptors ligand
5LKR-6yc BCHE Piperidine Carboxamide Naphthalen Alkyne
Piperidinyl-1,2,3-triazole-urea-inhibitor-12 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol Alkyne
ABT-279 DPP4N_Peptidase_S9 Pyrrolidine Alkyne
Alkynyl-cyanopyrrolidine-1 DPP4N_Peptidase_S9 Pyrrolidine Cyanide Alkyne
Alkynyl-cyanopyrrolidine-2 DPP4N_Peptidase_S9 Pyrrolidine Cyanide Alkyne
Contilisant ACHE BCHE Multitarget Histamine-Receptor3-H3-Antagonist Monoamine-oxidase-inhibitor Piperidine Indole Alkyne
ASS234 ACHE Multitarget Monoamine-oxidase-inhibitor Alkyl linked bis-ligand Piperidine Indole Alkyne
Linagliptin DPP4N_Peptidase_S9 Drug Purine Gliptin Quinazoline Alkyne
Pa5 ACHE Phenanthridinium Derivative of Propidium Alkyne
Pa6 ACHE Phenanthridinium Derivative of Propidium Alkyne
Barban ACHE Carbamate Herbicide Alkyne
CyC-31yne Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor Alkyne
CyC-32yne Carbon-carbon_bond_hydrolase Organophosphate Cyclic OP Lipase inhibitor Alkyne
Sal-A-alkyne Plasmodium_subtelomeric_PST-A ABHD13-BEM46 Duf_676 PGAP1 ABHD17-depalmitoylase Organophosphate Cyclic OP Lipase inhibitor ABPP-Probe Alkyne