Mycobacterium tuberculosis, Mycobacterium bovis, Rv2970c Carboxylic ester hydrolase lipN
Non specific carboxylic ester hydrolase. Hydrolyzes various pNP-esters, with a preference for short carbon chain substrates. Can also hydrolyze tributyrin to di- and monobutyrin and 4-hydroxyphenylacetate to hydroquinone. There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains
Family : Hormone-sensitive_lipase_like
Block : H
Position in NCBI Life Tree : Mycobacterium tuberculosis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Corynebacteriales N E > Mycobacteriaceae N E > Mycobacterium N E > Mycobacterium tuberculosis complex N E > Mycobacterium tuberculosis N EMTKSLPGVAD LRLGANHPRM WTRRVQGTVV NVGVKVLPWI PTPAKRILSA GRSVIIDGNT LDPTLQLMLS TSRIFGVDGL AVDDDIVASR AHMRAICEAM PGPQIHVDVT DLSIPGPAGE IPARHYRPSG GGATPLLVFY HGGGWTLGDL DTHDALCRLT CRDADIQVLS IDYRLAPEHP APAAVEDAYA AFVWAHEHAS DEFGALPGRV AVGGDSAGGN LSAVVCQLAR DKARYEGGPT PVLQWLLYPR TDFTAQTRSM GLFGNGFLLT KRDIDWFHTQ YLRDSDVDPA DPRLSPLLAE SLSGLAPALI AVAGFDPLRD EGESYAKALR AAGTAVDLRY LGSLTHGFLN LFQLGGGSAA GTNELISALR AHLSRV
Title : Sequence and Structural Motifs Controlling the Broad Substrate Specificity of the Mycobacterial Hormone-Sensitive Lipase LipN - Schemenauer_2023_ACS.Omega_8_13252 |
Author(s) : Schemenauer DE , Pool EH , Raynor SN , Ruiz GP , Goehring LM , Koelper AJ , Wilson MA , Durand AJ, Jr. , Kourtoglou EC , Larsen EM , Lavis LD , Esteb JJ , Hoops GC , Johnson RJ |
Ref : ACS Omega , 8 :13252 , 2023 |
Abstract : |
PubMedSearch : Schemenauer_2023_ACS.Omega_8_13252 |
PubMedID: 37065048 |
Gene_locus related to this paper: mycmm-b2h1k1 , myctu-Rv2970c |
Title : Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis - Nguyen_2017_Sci.Rep_7_11751 |
Author(s) : Nguyen PC , Delorme V , Benarouche A , Martin BP , Paudel R , Gnawali GR , Madani A , Puppo R , Landry V , Kremer L , Brodin P , Spilling CD , Cavalier JF , Canaan S |
Ref : Sci Rep , 7 :11751 , 2017 |
Abstract : |
PubMedSearch : Nguyen_2017_Sci.Rep_7_11751 |
PubMedID: 28924204 |
Gene_locus related to this paper: mycle-ML2603 , myctu-a85a , myctu-a85c , myctu-Rv1399c , myctu-Rv2970c , myctu-Rv3569c , myctu-yt28 |
Title : Small-Molecule Probes Reveal Esterases with Persistent Activity in Dormant and Reactivating Mycobacterium tuberculosis - Tallman_2016_ACS.Infect.Dis_2_936 |
Author(s) : Tallman KR , Levine SR , Beatty KE |
Ref : ACS Infect Dis , 2 :936 , 2016 |
Abstract : |
PubMedSearch : Tallman_2016_ACS.Infect.Dis_2_936 |
PubMedID: 27690385 |
Gene_locus related to this paper: myctu-rv0183 , myctu-Rv1399c , myctu-RV1683 , myctu-Rv2284 , myctu-Rv2970c , myctu-ym24 |
Title : Characterization of LipN (Rv2970c) of Mycobacterium Tuberculosis H37Rv and its Probable Role in Xenobiotic Degradation - Jadeja_2016_J.Cell.Biochem_117_390 |
Author(s) : Jadeja D , Dogra N , Arya S , Singh G , Kaur J |
Ref : Journal of Cellular Biochemistry , 117 :390 , 2016 |
Abstract : |
PubMedSearch : Jadeja_2016_J.Cell.Biochem_117_390 |
PubMedID: 26212120 |
Gene_locus related to this paper: myctu-Rv2970c |
Title : Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases - Lehmann_2016_Medchemcomm_7_1797 |
Author(s) : Lehmann J , Vomacka J , Esser K , Nodwell M , Kolbe K , Ramer P , Protzer U , Reiling N , Sieber SA |
Ref : Medchemcomm , 7 :1797 , 2016 |
Abstract : |
PubMedSearch : Lehmann_2016_Medchemcomm_7_1797 |
PubMedID: |
Gene_locus related to this paper: myctu-cutas1 , myctu-lipG , myctu-RV0045C , myctu-rv0183 , myctu-RV0293C , myctu-RV0840C , myctu-Rv1191 , myctu-RV1192 , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-Rv2045c , myctu-Rv2284 , myctu-Rv2970c , myctu-Rv3084 , myctu-YR15 , larcr-a0a0f7ir14 |
Title : Targeting Lipid Esterases in Mycobacteria Grown Under Different Physiological Conditions Using Activity-based Profiling with Tetrahydrolipstatin (THL) - Ravindran_2014_Mol.Cell.Proteomics_13_435 |
Author(s) : Ravindran MS , Rao SP , Cheng X , Shukla A , Cazenave-Gassiot A , Yao SQ , Wenk MR |
Ref : Mol Cell Proteomics , 13 :435 , 2014 |
Abstract : |
PubMedSearch : Ravindran_2014_Mol.Cell.Proteomics_13_435 |
PubMedID: 24345785 |
Gene_locus related to this paper: myctu-Rv2970c |
Title : MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth - Delorme_2012_PLoS.One_7_e46493 |
Author(s) : Delorme V , Diomande SV , Dedieu L , Cavalier JF , Carriere F , Kremer L , Leclaire J , Fotiadu F , Canaan S |
Ref : PLoS ONE , 7 :e46493 , 2012 |
Abstract : |
PubMedSearch : Delorme_2012_PLoS.One_7_e46493 |
PubMedID: 23029536 |
Gene_locus related to this paper: myctu-Rv2970c |
Title : Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv - Camus_2002_Microbiology_148_2967 |
Author(s) : Camus JC , Pryor MJ , Medigue C , Cole ST |
Ref : Microbiology , 148 :2967 , 2002 |
Abstract : |
PubMedSearch : Camus_2002_Microbiology_148_2967 |
PubMedID: 12368430 |
Gene_locus related to this paper: myctu-d5yk66 , myctu-ephA , myctu-ephB , myctu-LPQP , myctu-p71654 , myctu-Rv0160c , myctu-RV0774C , myctu-Rv2485c , myctu-RV2672 , myctu-RV2695 , myctu-RV2765 , myctu-RV2800 , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-RV3452 |
Title : An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae - Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
Author(s) : Philipp WJ , Poulet S , Eiglmeier K , Pascopella L , Balasubramanian V , Heym B , Bergh S , Bloom BR , Jacobs WR, Jr. , Cole ST |
Ref : Proc Natl Acad Sci U S A , 93 :3132 , 1996 |
Abstract : |
PubMedSearch : Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
PubMedID: 8610181 |
Gene_locus related to this paper: myctu-Rv0217c , myctu-Rv0220 , myctu-Rv1076 , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-Rv2045c , myctu-Rv2284 , myctu-Rv2385 , myctu-Rv2485c , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-Rv3487c |