Thieno-Oxazepine-Cpd14
IC50 AChE 0.39 +/- 0.01 BChE 2.93 +/- 0.10 microM
General
Type : Multitarget, Azepane, Sulfur Compound, Thiophen
Chemical_Nomenclature : 4-(4-Ethoxyphenyl)-3,4,7,8,9,10-hexahydro-6H-cyclohepta[4,5]thieno[3,2-f][1,4]oxazepine-2,5-dione
Canonical SMILES : C14=C(SC2=C1C(N(CC(O2)=O)C3=CC=C(C=C3)OCC)=O)CCCCC4
InChI : InChI=1S\/C20H21NO4S\/c1-2-24-14-10-8-13(9-11-14)21-12-17(22)25-20-18(19(21)23)15-6-4-3-5-7-16(15)26-20\/h8-11H,2-7,12H2,1H3
InChIKey : OGHAHUKFCKMKAU-UHFFFAOYSA-N
Other name(s) : Compound 14
Target
Families : Thieno-Oxazepine-Cpd14 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Unlocking Therapeutic Potential of Novel Thieno-Oxazepine Hybrids as Multi-Target Inhibitors of AChE\/BChE and Evaluation Against Alzheimer's Disease: In Vivo, In Vitro, Histopathological, and Docking Studies - Oudah_2025_Pharmaceuticals.(Basel)_18_ |
| Author(s) : Oudah KH , Najm MAA , Ramsis TM , Ebrahim MA , Gohar NA , Abu-Elfotuh K , Mohamed EK , Hamdan AME , Hamdan AM , Almotairi R , Abdelmohsen SR , Abdelhakim KR , Elsharkawy AMA , Fayed EA |
| Ref : Pharmaceuticals (Basel) , 18 : , 2025 |
| Abstract : |
| PubMedSearch : Oudah_2025_Pharmaceuticals.(Basel)_18_ |
| PubMedID: 40872605 |