Trifluoromethyl-thiophene-boronic-acid
IC50 FphH 0.051 +/- 0.016 microM FphE 0.73 +/- 0.03 microM
General
Type : Trifluoro, Boron compound, Sulfur Compound, Thiophen
Chemical_Nomenclature : [5-(trifluoromethyl)thiophen-2-yl]boronic acid
Canonical SMILES : B(C1=CC=C(S1)C(F)(F)F)(O)O
InChI : InChI=1S\/C5H4BF3O2S\/c7-5(8,9)3-1-2-4(12-3)6(10)11\/h1-2,10-11H
InChIKey : NHBZQJOZVBHDAZ-UHFFFAOYSA-N
Other name(s) : 5-Trifluoromethyl-thiophene-2-boronic acid || (5-(trifluoromethyl)thiophen-2-yl)boronic acid || 5-(trifluoromethyl)thiophen-2-ylboronic acid || [5-(Trifluoromethyl)thiophen-2-yl]boronic acid || compound N34 || SCHEMBL12538574
MW : 195.96
Formula : C5H4BF3O2S
CAS_number : 958451-91-7
PubChem : 45158752
UniChem : NHBZQJOZVBHDAZ-UHFFFAOYSA-N
Target
Families : Trifluoromethyl-thiophene-boronic-acid ligand of proteins in family
6_AlphaBeta_hydrolase
CarbLipBact_1
Protein :
staau-SA2367
staau-MW0741
References (1)
| Title : Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation - Upadhyay_2025_Nat.Commun_16_5046 |
| Author(s) : Upadhyay T , Woods EC , Dela Ahator S , Julin K , Faucher FF , Uddin MJ , Hollander MJ , Pedowitz NJ , Abegg D , Hammond I , Eke IE , Wang S , Chen S , Bennett JM , Jo J , Lentz CS , Adibekian A , Fellner M , Bogyo M |
| Ref : Nat Commun , 16 :5046 , 2025 |
| Abstract : |
| PubMedSearch : Upadhyay_2025_Nat.Commun_16_5046 |
| PubMedID: 40447595 |
| Gene_locus related to this paper: staau-MW0741 , staau-SA2367 , staep-SE2095 |