IC50 140 nM for AChE; IC50 450 nM for MAO-B isoform
Type : Monoamine-oxidase-inhibitor, Multitarget, Pyrrolidine, Chromen
Chemical_Nomenclature : 2-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-4H-chromen-4-one
Canonical SMILES : C1=CC=C2C(=C1)C(C=C(O2)C3=CC(=C(C=C3)OCCN4CCCC4)OC)=O
InChI : InChI=1S\/C22H23NO4\/c1-25-22-14-16(8-9-20(22)26-13-12-23-10-4-5-11-23)21-15-18(24)17-6-2-3-7-19(17)27-21\/h2-3,6-9,14-15H,4-5,10-13H2,1H3
InChIKey : QIKUOOZSYADVRG-UHFFFAOYSA-N
Other name(s) :
Families : VN-19 ligand of proteins in family
ACHE
Protein :
human-ACHE
Title : In Vitro and In Vivo Investigations of Chromone Derivatives as Potential Multitarget-Directed Ligands: Cognitive Amelioration Utilizing a Scopolamine-Induced Zebrafish Model - Kumar_2024_ACS.Chem.Neurosci__ |
Author(s) : Kumar N , Jangid K , Kumar V , Yadav RP , Mishra J , Upadhayay S , Devi B , Dwivedi AR , Kumar P , Baranwal S , Bhatti JS |
Ref : ACS Chem Neurosci , : , 2024 |
Abstract : |
PubMedSearch : Kumar_2024_ACS.Chem.Neurosci__ |
PubMedID: 38795037 |