Val-Ala-Met-Pro
human DPP-IV IC50=1.00 microM
General
Type : Peptide, Sulfur Compound
Chemical_Nomenclature : H-Val-Ala-Meth-Pro-OH
Canonical SMILES : CSCC[C@H](NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)C(=O)N1[C@@H](CCC1)C(O)=O
InChI : InChI=1S\/C18H32N4O5S\/c1-10(2)14(19)16(24)20-11(3)15(23)21-12(7-9-28-4)17(25)22-8-5-6-13(22)18(26)27\/h10-14H,5-9,19H2,1-4H3,(H,20,24)(H,21,23)(H,26,27)\/t11-,12-,13-,14-\/m0\/s1
InChIKey : LSLRAHKQFLMMHO-XUXIUFHCSA-N
Other name(s) : Valinylalanylmethionylproline || VAMP tetrapeptide || VAMP || Valine-Alanine-Methionine-Proline tetrapeptide || Valine Alanine Methionine Proline tetrapeptide || Val-Ala-Meth-Pro || Val-Ala-Met-Pro
Target
Families : Val-Ala-Met-Pro ligand of proteins in family
DPP4N_Peptidase_S9
Structure :
9LBT
Protein :
human-DPP4
References (2)
| Title : Discovery of a novel tetrapeptide as glucose homeostasis modulator with bifunctionalities of targeting DPP-IV and microbiota - Chen_2025_Imeta_4_e70072 |
| Author(s) : Chen H , Li W , Hu W , Liu J , Zhang C , Wang Y , Zhang X , Chen S , Nie Q , Xing X |
| Ref : Imeta , 4 :e70072 , 2025 |
| Abstract : |
| PubMedSearch : Chen_2025_Imeta_4_e70072 |
| PubMedID: 41112055 |
| Gene_locus related to this paper: human-DPP4 |
| Title : A novel bifunctional peptide VAMP mined from hemp seed protein hydrolysates improves glucose homeostasis by inhibiting intestinal DPP-IV and increasing the abundance of Akkermansia muciniphila - Chen_2024_bioRxiv__ |
| Author(s) : Chen H , Li W , Hu W , Xu B , Wang Y , Liu J , Zhang C , Zhang X , Nie Q , Xing XH |
| Ref : bioRxiv , : , 2024 |
| Abstract : |
| PubMedSearch : Chen_2024_bioRxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-DPP4 |