| Title : Discovery of a novel tetrapeptide as glucose homeostasis modulator with bifunctionalities of targeting DPP-IV and microbiota - Chen_2025_Imeta_4_e70072 |
| Author(s) : Chen H , Li W , Hu W , Liu J , Zhang C , Wang Y , Zhang X , Chen S , Nie Q , Xing X |
| Ref : Imeta , 4 :e70072 , 2025 |
|
Abstract :
AI-driven and computation-based high-throughput methods were developed to mine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from hemp seed proteins. The identified peptide VAMP demonstrates a glucose-lowering effect through dual mechanisms: inhibition of DPP-IV activity and selective promotion of intestinal Akkermansia muciniphila growth. |
| PubMedSearch : Chen_2025_Imeta_4_e70072 |
| PubMedID: 41112055 |
| Gene_locus related to this paper: human-DPP4 |
| Inhibitor | Val-Ala-Met-Pro |
| Gene_locus | human-DPP4 |
| Structure | 9LBT |
Chen H, Li W, Hu W, Liu J, Zhang C, Wang Y, Zhang X, Chen S, Nie Q, Xing X (2025)
Discovery of a novel tetrapeptide as glucose homeostasis modulator with bifunctionalities of targeting DPP-IV and microbiota
Imeta
4 :e70072
Chen H, Li W, Hu W, Liu J, Zhang C, Wang Y, Zhang X, Chen S, Nie Q, Xing X (2025)
Imeta
4 :e70072