ZQ-19
covalent inhibitor
General
Type : Cyanide, Pyridine, Sulfur Compound
Chemical_Nomenclature : ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-[(3-cyano-6-ethyl-5-methylpyridin-2-yl)sulfanylmethyl]-4H-thiopyran-3-carboxylate
Canonical SMILES : CCC1=NC(=C(C=C1C)C#N)SCC2=C(C(C(=C(S2)N)C#N)C3=CC=C(C=C3)Cl)C(=O)OCC
InChI : InChI=1S\/C25H23ClN4O2S2\/c1-4-19-14(3)10-16(11-27)24(30-19)33-13-20-22(25(31)32-5-2)21(18(12-28)23(29)34-20)15-6-8-17(26)9-7-15\/h6-10,21H,4-5,13,29H2,1-3H3
InChIKey : ATTTXACFHDEILL-UHFFFAOYSA-N
Other name(s) : AK-777\/36935005
MW : 511.1
Formula : C25H23ClN4O2S2
CAS_number :
PubChem : 4071019
UniChem : ATTTXACFHDEILL-UHFFFAOYSA-N
Target
Families : ZQ-19 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock - Wang_2025_Bioorg.Chem_159_108378 |
| Author(s) : Wang J , Shi X , Zheng Q , Shao P , Liu S |
| Ref : Bioorg Chem , 159 :108378 , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_Bioorg.Chem_159_108378 |
| PubMedID: 40107037 |