eFAP-9
eFAP-9 IC50 hFAP 2.9 +/- 0.6 nM; mFAP 2.3 +/- 0.3 nM; PREP 45.1 +/- 4.1 nM; DPP4 40250 nM. Radiolabeling with [111In] [111In]In-eFAP-9
General
Type : PET probe, Tetrazacyclododec, Pyrrolidine, Quinoline, cyanide
Chemical_Nomenclature : 2,2',2''-(10-(2-(((4-((3-((4-((2-((S)-2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-8-yl)oxy)propyl)carbamoyl)cyclohexyl)methyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid || 2-[4,7-bis(carboxymethyl)-10-[2-[[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-8-yl]oxypropylcarbamoyl]cyclohexyl]methylamino]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic aci
Canonical SMILES : C1CC(CCC1CNC(=O)CN2CCN(CCN(CCN(CC2)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)NCCCOC3=CC=CC4=C(C=CN=C43)C(=O)NCC(=O)N5CC(C[C@H]5C#N)(F)F
InChI : InChI=1S\/C44H60F2N10O11\/c45-44(46)21-32(22-47)56(29-44)37(58)24-51-43(66)34-9-11-48-41-33(34)3-1-4-35(41)67-20-2-10-49-42(65)31-7-5-30(6-8-31)23-50-36(57)25-52-12-14-53(26-38(59)60)16-18-55(28-40(63)64)19-17-54(15-13-52)27-39(61)62\/h1,3-4,9,11,30-32H,2,5-8,10,12-21,23-29H2,(H,49,65)(H,50,57)(H,51,66)(H,59,60)(H,61,62)(H,63,64)\/t30?,31?,32-\/m0\/s1
InChIKey : QUPHDEMIWMQGNI-PDZHLSQESA-N
Other name(s) : SCHEMBL27175937 || [111In]In-eFAP-9
MW : 943.0
Formula : C44H60F2N10O11
CAS_number :
PubChem : 174219078, 171102363
UniChem : QUPHDEMIWMQGNI-PDZHLSQESA-N
Target
Families : eFAP-9 ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-FAP
References (1)
| Title : A new series of FAP inhibitors for cancer imaging based on 8-substituted (4-quinolinoyl)-glycyl-2-cyanopyrrolidine - Ma_2026_Nucl.Med.Biol_158-159_109661 |
| Author(s) : Ma H , Li L , Piet A , Handula M , de Ridder C , Stuurman D , Seimbille Y |
| Ref : Nucl Med Biol , 158-159 :109661 , 2026 |
| Abstract : |
| PubMedSearch : Ma_2026_Nucl.Med.Biol_158-159_109661 |
| PubMedID: 42526425 |
| Gene_locus related to this paper: human-FAP |