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Dibutyl-dichlorovinyl-phosphate~DBVP

potent organophosphorus neuropathy target esterase (NTE not alpha/beta hydrolase) inhibitor

General

Type : Organophosphate,NTE inhibitor,Not A\/B H target

Chemical_Nomenclature : 1-(butoxy-(2,2-dichloroethenoxy)phosphoryl)oxybutane

Canonical SMILES : CCCCOP(=O)(OCCCC)OC(=CCl)Cl

InChI : InChI=1S\/C10H19Cl2O4P\/c1-3-5-7-14-17(13,15-8-6-4-2)16-10(12)9-11\/h9H,3-8H2,1-2H3

InChIKey : ZRSXWECQLMXKHF-UHFFFAOYSA-N

Other name(s) : DBDCVP,DBVP,di-n-butyl dichlorvos,2,2-dichlorovinyldibutylphosphate,Dibutyl 2,2-dichlorovinyl phosphate,EINECS 242-584-1,BRN 1712889,Di-n-butyl-2,2-dichlorovinyl phosphate [MeSH: di-n-butyl-2,2-dichlorovinyl phosphate],AI3-20756,Phosphoric acid, dibutyl 2,2-dichlorovinyl ester,4-01-00-02064,Phosphoric acid, dibutyl 2,2-dichloroethenyl ester,18795-58-9

MW : 305.13

Formula : C10H19Cl2O4P

CAS_number :

PubChem : 54562823

UniChem : ZRSXWECQLMXKHF-UHFFFAOYSA-N

Target

Families : Dibutyl-dichlorovinyl-phosphate~DBVP ligand of proteins in family
Carb_B_Chordata

References (9)

Title : Effects of S-ethyl hexahydro-1H-azepine-1-carbothioate (molinate) on di-n-butyl dichlorovinyl phosphate (DBDCVP) neuropathy - Moretto_2001_Toxicol.Sci_62_274
Author(s) : Moretto A , Gardiman G , Panfilo S , Colle MA , Lock EA , Lotti M
Ref : Toxicol Sci , 62 :274 , 2001
Abstract : Moretto_2001_Toxicol.Sci_62_274
ESTHER : Moretto_2001_Toxicol.Sci_62_274
PubMedSearch : Moretto_2001_Toxicol.Sci_62_274
PubMedID: 11452140

Title : Brainstem axolemmal protein phosphorylation in vitro in hens dosed with di-1-butyl-2,2-dichlorovinyl phosphate - Huggins_1999_J.Toxicol.Environ.Health.A_56_263
Author(s) : Huggins DJ , Richardson RJ
Ref : J Toxicol Environ Health A , 56 :263 , 1999
Abstract : Huggins_1999_J.Toxicol.Environ.Health.A_56_263
ESTHER : Huggins_1999_J.Toxicol.Environ.Health.A_56_263
PubMedSearch : Huggins_1999_J.Toxicol.Environ.Health.A_56_263
PubMedID: 10706244

Title : Inhibition of carboxylesterases in SH-SY5Y human and NB41A3 mouse neuroblastoma cells by organophosphorus esters - Ehrich_1998_J.Toxicol.Environ.Health_53_385
Author(s) : Ehrich M , Correll L
Ref : J Toxicol Environ Health , 53 :385 , 1998
Abstract : Ehrich_1998_J.Toxicol.Environ.Health_53_385
ESTHER : Ehrich_1998_J.Toxicol.Environ.Health_53_385
PubMedSearch : Ehrich_1998_J.Toxicol.Environ.Health_53_385
PubMedID: 9515941

Title : Organophosphate polyneuropathy in chicks - Peraica_1993_Biochem.Pharmacol_45_131
Author(s) : Peraica M , Capodicasa E , Moretto A , Lotti M
Ref : Biochemical Pharmacology , 45 :131 , 1993
Abstract : Peraica_1993_Biochem.Pharmacol_45_131
ESTHER : Peraica_1993_Biochem.Pharmacol_45_131
PubMedSearch : Peraica_1993_Biochem.Pharmacol_45_131
PubMedID: 8381002

Title : Clinical expression of organophosphate-induced delayed polyneuropathy in rats [published erratum appears in Toxicol Lett 1992 Dec\;63(3):355] - Moretto_1992_Toxicol.Lett_63_97
Author(s) : Moretto A , Capodicasa E , Lotti M
Ref : Toxicol Lett , 63 :97 , 1992
Abstract : Moretto_1992_Toxicol.Lett_63_97
ESTHER : Moretto_1992_Toxicol.Lett_63_97
PubMedSearch : Moretto_1992_Toxicol.Lett_63_97
PubMedID: 1412529

Title : Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochemical and toxicological studies in developing chicks - Moretto_1991_Biochem.Pharmacol_41_1497
Author(s) : Moretto A , Capodicasa E , Peraica M , Lotti M
Ref : Biochemical Pharmacology , 41 :1497 , 1991
Abstract : Moretto_1991_Biochem.Pharmacol_41_1497
ESTHER : Moretto_1991_Biochem.Pharmacol_41_1497
PubMedSearch : Moretto_1991_Biochem.Pharmacol_41_1497
PubMedID: 2018554

Title : In vivo and in vitro regional differential sensitivity of neuropathy target esterase to di-n-butyl-2,2-dichlorovinyl phosphate - Moretto_1989_Arch.Toxicol_63_469
Author(s) : Moretto A , Lotti M , Spencer PS
Ref : Archives of Toxicology , 63 :469 , 1989
Abstract : Moretto_1989_Arch.Toxicol_63_469
ESTHER : Moretto_1989_Arch.Toxicol_63_469
PubMedSearch : Moretto_1989_Arch.Toxicol_63_469
PubMedID: 2619560

Title : Time course of electrophysiologic effects induced by di-n-butyl-2,2-dichlorovinyl phosphate (DBCV) in the adult hen - Robertson_1988_J.Toxicol.Environ.Health_23_283
Author(s) : Robertson DG , Mattson AM , Bestervelt LL , Richardson RJ , Anderson RJ
Ref : J Toxicol Environ Health , 23 :283 , 1988
Abstract : Robertson_1988_J.Toxicol.Environ.Health_23_283
ESTHER : Robertson_1988_J.Toxicol.Environ.Health_23_283
PubMedSearch : Robertson_1988_J.Toxicol.Environ.Health_23_283
PubMedID: 3351976

Title : Progressive deficit of retrograde axonal transport is associated with the pathogenesis of di-n-butyl dichlorvos axonopathy - Moretto_1987_J.Neurochem_49_1515
Author(s) : Moretto A , Lotti M , Sabri MI , Spencer PS
Ref : Journal of Neurochemistry , 49 :1515 , 1987
Abstract : Moretto_1987_J.Neurochem_49_1515
ESTHER : Moretto_1987_J.Neurochem_49_1515
PubMedSearch : Moretto_1987_J.Neurochem_49_1515
PubMedID: 2444671 
Array
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    [id] => 5016
    [inhibitor] => Dibutyl-dichlorovinyl-phosphate~DBVP
    [type] => Array
        (
            [0] => Organophosphate
            [1] => NTE inhibitor
            [2] => Not A\/B H target
        )

    [other_name] => Array
        (
            [0] => DBDCVP
            [1] => DBVP
            [2] => di-n-butyl dichlorvos
            [3] => 2,2-dichlorovinyldibutylphosphate
            [4] => Dibutyl 2,2-dichlorovinyl phosphate
            [5] => EINECS 242-584-1
            [6] => BRN 1712889
            [7] => Di-n-butyl-2,2-dichlorovinyl phosphate [MeSH: di-n-butyl-2,2-dichlorovinyl phosphate]
            [8] => AI3-20756
            [9] => Phosphoric acid, dibutyl 2,2-dichlorovinyl ester
            [10] => 4-01-00-02064
            [11] => Phosphoric acid, dibutyl 2,2-dichloroethenyl ester
            [12] => 18795-58-9
        )

    [chemical_nomenclature] => 1-(butoxy-(2,2-dichloroethenoxy)phosphoryl)oxybutane
    [formula] => C10H19Cl2O4P
    [cas_number] => 
    [mw] => 305.13
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Ehrich_1998_J.Toxicol.Environ.Health_53_385 || Moretto_2001_Toxicol.Sci_62_274 || Huggins_1999_J.Toxicol.Environ.Health.A_56_263 || Peraica_1993_Biochem.Pharmacol_45_131 || Moretto_1992_Toxicol.Lett_63_97 || Moretto_1991_Biochem.Pharmacol_41_1497 || Moretto_1989_Arch.Toxicol_63_469 || Robertson_1988_J.Toxicol.Environ.Health_23_283 || Moretto_1987_J.Neurochem_49_1515
    [comment] => potent organophosphorus neuropathy target esterase (NTE not alpha\/beta hydrolase) inhibitor
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 54562823
    [family] => Carb_B_Chordata
    [inchikey] => ZRSXWECQLMXKHF-UHFFFAOYSA-N
    [canonicalsmiles] => CCCCOP(=O)(OCCCC)OC(=CCl)Cl
    [inchi] => InChI=1S\/C10H19Cl2O4P\/c1-3-5-7-14-17(13,15-8-6-4-2)16-10(12)9-11\/h9H,3-8H2,1-2H3
    [wikipedia] => 
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    [structure] => 
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)