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Inhibitor Report for: 5LP1-71H


General
Type: Trifluoro, Pyrimidine, Sulfur Compound
Chemical_Nomenclature: N-[2-(diethylamino)ethyl]-2-[2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-7aH-cyclopenta[d]pyrimidin-1-yl]-N-[[3-[4-(trifluoromethyl)phenyl]-1-bicyclo[1.1.1]pentanyl]methyl]acetamide
Canonical SMILES: CCN(CC)CCN(CC12CC(C1)(C2)C3=CC=C(C=C3)C(F)(F)F)C(=O)CN4C5C=CC=C5C(=O)N=C4SCC6=CC=C(C=C6)F
InChI: InChI=1S/C35H38F4N4O2S/c1-3-41(4-2)16-17-42(23-33-20-34(21-33,22-33)25-10-12-26(13-11-25)35(37,38)39)30(44)18-43-29-7-5-6-28(29)31(45)40-32(43)46-19-24-8-14-27(36)15-9-24/h5-15,29H,3-4,16-23H2,1-2H3
InChIKey: DSRJYUBKWVSYFE-UHFFFAOYSA-N
Other name(s): 71H
MW: 654.76
Formula: C35H38F4N4O2S
CAS_number:
PubChem: 124080846
IUPHAR:
Wikipedia:

Target families
5LP1-71H ligand of proteins in family: PAF-Acetylhydrolase

Stucture of targets
1 structure:
5LP1: Crystal structure of human lipoprotein-associated phospholipase A2 in complex with a [1.1.1]bicyclopentane- containing inhibitor at 1.91 A resolution

Protein target
Enzyme: human-PLA2G7

References
Search PubMed for references concerning: 5LP1-71H
    Title: Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor
    Measom ND, Down KD, Hirst DJ, Jamieson C, Manas ES, Patel VK, Somers DO
    Ref: ACS Med Chem Lett, 8:43, 2017 : PubMed