A-262-Nerve-agent

Novichok (newcomer/ newbie/ novice, beginner/) is a series of binary chemical weapons developed by the Soviet Union and Russia between 1971 and 1993. Mirzayanov provided the first description of these agents but are somewhat different from the structures identified later. A-262 is not specifically listed in the Annex on Chemicals of the Chemical Weapons Convention, and falls outside the general definitions covering other Novichok agents, even though it has a chemical structure similar to that of both A-232 (the example compound for schedule 1.A.14) and A-242 (the example compound for schedule 1.A.15)

General

Type : Organophosphate,Chemical Warfare Agent,Novichok

Chemical_Nomenclature : 1,1,3,3-tetraethyl-2-[fluoro(methoxy)phosphoryl]guanidine

Canonical SMILES : CCN(CC)C(=NP(=O)(OC)F)N(CC)CC

InChI : InChI=1S\/C10H23FN3O2P\/c1-6-13(7-2)10(14(8-3)9-4)12-17(11,15)16-5\/h6-9H2,1-5H3

InChIKey : AEQJLRXTEIZQBQ-UHFFFAOYSA-N

Other name(s) : A-262 nerve agent,A-262,A262,MCL38N4DHF,SCHEMBL23866424,DTXSID801336561


MW : 267.28

Formula : C10H23FN3O2P

CAS_number :

PubChem : 149628685

UniChem : AEQJLRXTEIZQBQ-UHFFFAOYSA-N

IUPHAR :

Wikipedia : Novichok_agent

Target

Families : A-262-Nerve-agent ligand of proteins in family: ACHE

Stucture :

Protein : human-ACHE

References (3)

Title : In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents' surrogates - Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678
Author(s) : Kitagawa DAS , Dos Santos MC , Kuca K , Franca TCC , Cavalcante SFA
Ref : Chemico-Biological Interactions , 383 :110678 , 2023
Abstract : Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678
ESTHER : Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678
PubMedSearch : Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678
PubMedID: 37595776

Title : Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series? - Santos_2022_Arch.Toxicol__
Author(s) : Santos MC , Botelho FD , Goncalves AS , Kitagawa DAS , Borges CVN , Carvalho-Silva T , Bernardo LB , Ferreira CN , Rodrigues RB , Ferreira Neto DC , Nepovimova E , Kuca K , LaPlante SR , Lima ALS , Franca TCC , Cavalcante SFA
Ref : Archives of Toxicology , : , 2022
Abstract : Santos_2022_Arch.Toxicol__
ESTHER : Santos_2022_Arch.Toxicol__
PubMedSearch : Santos_2022_Arch.Toxicol__
PubMedID: 35666269

Title : Novichok nerve agents banned by chemical-weapons treaty -
Author(s) : Castelvecchi D
Ref : Nature , : , 2019
PubMedID: 33244185