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Inhibitor Report for: CHEMBL3924430

CHEMBL3924430 (Structure 5LZ7) CHEMBL3983270 (Structure 5LZ5) are enantiomers


General
Type Pyrrolidine, Oxidanylidene, Cyanide
Chemical_Nomenclature 2-fluoro-5-[2-[(4R)-4-methyl-2-oxo-4-phenylpyrrolidin-1-yl]ethoxy]benzonitrile
Canonical SMILES CC1(CC(=O)N(C1)CCOC2=CC(=C(C=C2)F)C#N)C3=CC=CC=C3
InChI InChI=1S/C20H19FN2O2/c1-20(16-5-3-2-4-6-16)12-19(24)23(14-20)9-10-25-17-7-8-18(21)15(11-17)13-22/h2-8,11H,9-10,12,14H2,1H3/t20-/m0/s1
InChIKey WMVNTKWNIVSPIC-FQEVSTJZSA-N
Other name(s) 2-Fluoranyl-5-[2-[(4~{r})-4-Methyl-2-Oxidanylidene-4-Phenyl-Pyrrolidin-1-Yl]ethoxy]benzenecarbonitrile ; BDBM50197661 ; 7BK
________________________________________________________________________________________________
MW|338.4
Formula|C20H19FN2O2
CAS_number|
PubChem|122707118
UniChem|WMVNTKWNIVSPIC-FQEVSTJZSA-N
IUPHAR|
Wikipedia|

Target
Families | CHEMBL3924430 ligand of proteins in family: PAF-Acetylhydrolase
Stucture | 1 structure: 5LZ7: Fragment-based inhibitors of Lipoprotein associated Phospholipase A2
Protein | human-PLA2G7

References:
Search PubMed for references concerning: CHEMBL3924430
    Title: Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)
    Woolford AJ, Day PJ, Beneton V, Berdini V, Coyle JE, Dudit Y, Grondin P, Huet P, Lee LY and Zhang X <11 more author(s)>
    Ref: Journal of Medicinal Chemistry, 59:10738, 2016 : PubMed