Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Harmine

Alkaloid isolated from seeds of Peganum harmala; Zygophyllacea. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants.It has a role as a metabolite, an anti-HIV agent and an EC 1.4.3.4 (monoamine oxidase) inhibitor.


General
Type Natural, Alkaloid, beta-carboline
Chemical_Nomenclature 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
Canonical SMILES CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChIKey BXNJHAXVSOCGBA-UHFFFAOYSA-N
Other name(s) Banisterine ; Telepathine
________________________________________________________________________________________________
MW|212.25
Formula|C13H12N2O
CAS_number|442-51-3
PubChem|5280953
UniChem|BXNJHAXVSOCGBA-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: Harmine

8 more
    Title: Effects of the Natural beta-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies
    Dos Santos RG, Hallak JE
    Ref: J Psychoactive Drugs, :1, 2016 : PubMed

            

    Title: Synthesis, cytotoxic, anti-lipoxygenase and anti-acetylcholinesterase capacities of novel derivatives from harmine
    Filali I, Belkacem MA, Ben Nejma A, Souchard JP, Ben Jannet H, Bouajila J
    Ref: J Enzyme Inhib Med Chem, 31(sup1):23, 2016 : PubMed

            

    Title: Synthesis of new isoxazoline derivatives from harmine and evaluation of their anti-Alzheimer, anti-cancer and anti-inflammatory activities
    Filali I, Bouajila J, Znati M, Bousejra-El Garah F, Ben Jannet H
    Ref: J Enzyme Inhib Med Chem, 30:371, 2015 : PubMed