Methyldifazine
Inhibition of human plasma BChE IC50 3.37 microM Inhibition of Torpedo californica AChE IC50 34.7 microM
General
Type : Phenothiazine, Sulfur Compound
Chemical_Nomenclature : 2-(diethylamino)-1-phenothiazin-10-ylpropan-1-one
Canonical SMILES : CCN(CC)C(C)C(=O)N1C2=CC=CC=C2SC3=CC=CC=C31
InChI : InChI=1S\/C19H22N2OS\/c1-4-20(5-2)14(3)19(22)21-15-10-6-8-12-17(15)23-18-13-9-7-11-16(18)21\/h6-14H,4-5H2,1-3H3
InChIKey : QCEWCMMSOWEHFC-UHFFFAOYSA-N
Other name(s) : AS-1397 || Methyldifazine || 10-(2-(Diethylamino)propionyl)phenothiazine || 10-(alpha-Diethylaminopropionyl)-phenothiazine hydrochloride || Lopac0_000351 || CHEMBL376514 || SCHEMBL1320997
Target
Families : Methyldifazine ligand of proteins in family
BCHE
Protein :
human-BCHE
References (2)
| Title : Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase - Elsinghorst_2006_J.Med.Chem_49_7540 |
| Author(s) : Elsinghorst PW , Tanarro CM , Gutschow M |
| Ref : Journal of Medicinal Chemistry , 49 :7540 , 2006 |
| Abstract : |
| PubMedSearch : Elsinghorst_2006_J.Med.Chem_49_7540 |
| PubMedID: 17149883 |
| Title : In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure - Mosnaim_2003_Pharmacology_67_6 |
| Author(s) : Mosnaim AD , Puente J , Saavedra R , Diamond S , Wolf ME |
| Ref : Pharmacology , 67 :6 , 2003 |
| Abstract : |
| PubMedSearch : Mosnaim_2003_Pharmacology_67_6 |
| PubMedID: 12444298 |