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Inhibitor Report for: PHK

General
Type Peptide, Halo ketone
Chemical_Nomenclature (2R,3S)-3-amino-1-chloro-4-phenylbutan-2-ol
Canonical SMILES C1=CC=C(C=C1)CC(C(CCl)O)N
InChI InChI=1S/C10H14ClNO/c11-7-10(13)9(12)6-8-4-2-1-3-5-8/h1-5,9-10,13H,6-7,12H2/t9-,10-/m0/s1
InChIKey YXWOYBQZWSLSMU-UWVGGRQHSA-N
Other name(s) 3-amino-1-chloro-4-phenyl-butanol-2-yl ; phenylalanyl chloromethylketone ; PCK ; AC1NRCRI ; SCHEMBL996512 ; ZINC12504342 ; DB04415
________________________________________________________________________________________________
MW|199.67
Formula|C10H14ClNO
CAS_number|
PubChem|5289149
UniChem|YXWOYBQZWSLSMU-UWVGGRQHSA-N
IUPHAR|
Wikipedia|

Target
Families | PHK ligand of proteins in family: Proline_iminopeptidase
Stucture | 3 structures: 1XQX, 1XRL, 1MU0
Protein | theac-pip

References:
Search PubMed for references concerning: PHK
    Title: X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum
    Goettig P, Brandstetter H, Groll M, Gohring W, Konarev PV, Svergun DI, Huber R, Kim JS
    Ref: Journal of Biological Chemistry, 280:33387, 2005 : PubMed

            

    Title: Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism
    Goettig P, Groll M, Kim JS, Huber R, Brandstetter H
    Ref: EMBO Journal, 21:5343, 2002 : PubMed