Halo ketone

General

Building block for many inhibitors of enzymes

Inhibitor	Main targeted enzyme families	Type
8-mercapto-1,1,1-tri-fluoro-2-octanone	Juvenile_hormone_esterase	Trifluoro Sulfur Compound Halo ketone
6AX1-cp3	Monoglyceridelipase_lysophospholip	Halo ketone Trifluoro Carbamate Azetidin Oxadiazol
Hexafluoracetone	Hydroxynitrile_lyase	Trifluoro Halo ketone
OTFP	Juvenile_hormone_esterase Cutinase	Trifluoro Halo ketone Sulfur Compound
DETFP	Juvenile_hormone_esterase Carb_B_Chordata Carboxylesterase	Trifluoro Sulfur Compound Halo ketone
OTFPdOHSO2	Juvenile_hormone_esterase	Trifluoro Sulfur Compound Sulfonyl Halo ketone
PHK	Proline_iminopeptidase	Peptide Halo ketone
JW651	Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A	Piperazine Halo ketone Carbamate Trifluoro
KML29	Monoglyceridelipase_lysophospholip Plasmodium_subtelomeric_PST-A	Halo ketone Piperidine Benzodioxo Carbamate Trifluoro
Zifrosilone	ACHE	Halo ketone Transition state analogue Trifluoro
1-Chloro-3-phenoxy-2-propanone	ACHE	Halo ketone Ketone Transition state analogue
6-Dimethyl-3-difluoro-2-heptanone	ACHE	Halo ketone Transition state analogue Analogue of substrate
Coumarinyl-ethyl-p-trifluoroacetamidophenylmethylphosphonate	BCHE	Trifluoro Organophosphate Halo ketone Coumarin Chromen
TBTFA	ACHE BCHE	Halo ketone Transition state analogue Trifluoro tert-Butyl
MBTFP	Cutinase Juvenile_hormone_esterase	Trifluoro Transition state analogue Halo ketone Sulfur Compound
TMTFA	ACHE	Trifluoro Trimethylammonium Quaternary compound Transition state analogue Halo ketone
Trifluoro-6-dimethyl-2-heptanone	BCHE ACHE	Trifluoro Halo ketone