Proline_iminopeptidase

Relationship

Family: Proline_iminopeptidase

Block: X

Parent Family: No family

Comment

This entry describes a subfamily of the alpha/beta fold family. This entry represents a of serine peptidase belonging to peptidase family S33 (clan SC). Family members include prolinases (Pro-Xaa dipeptidase, EC:3.4.13.18), prolyl aminopeptidases (EC:3.4.11.5), and a leucyl aminopeptidase. Prolyl aminopeptidase Pro_amnoPtase (S33 family) PROAMNOPTASE Pept_S33_TRI_F1 Pro_imino_pep_2. (Crystal structure of the proline iminopeptidase-related protein TTHA1809 from Thermus thermophilus HB8 (2YYS) showed that it lacks the active site serine and probably similar proteins play non enzymatic role in a few bacteria: Okai et al.2008)

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (24)

Genes Proteins in Proline_iminopeptidase family (1003)

Fragments of genes in Proline_iminopeptidase family (36)

Structures in Proline_iminopeptidase family (24)

Substrates in Proline_iminopeptidase family (10)

Inhibitors in Proline_iminopeptidase family (4)

References (9)

Title : Crystal structure of the proline iminopeptidase-related protein TTHA1809 from Thermus thermophilus HB8 - Okada_2008_J.Food.Sci_73_C146
Author(s) : Okai M , Miyauchi Y , Ebihara A , Lee WC , Nagata K , Tanokura M
Ref : Proteins , 70 :1646 , 2008
PubMedID: 18175319
Gene_locus related to this paper: thet2-q72hm9

Title : Unusual extra space at the active site and high activity for acetylated hydroxyproline of prolyl aminopeptidase from Serratia marcescens - Nakajima_2006_J.Bacteriol_188_1599
Author(s) : Nakajima Y , Ito K , Sakata M , Xu Y , Nakashima K , Matsubara F , Hatakeyama S , Yoshimoto T
Ref : Journal of Bacteriology , 188 :1599 , 2006
PubMedID: 16452443
Gene_locus related to this paper: serma-impep

Title : X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum - Goettig_2005_J.Biol.Chem_280_33387
Author(s) : Goettig P , Brandstetter H , Groll M , Gohring W , Konarev PV , Svergun DI , Huber R , Kim JS
Ref : Journal of Biological Chemistry , 280 :33387 , 2005
PubMedID: 15994304
Gene_locus related to this paper: theac-pip

Title : Molecular and genetic characterization of propionicin F, a bacteriocin from Propionibacterium freudenreichii - Brede_2004_Appl.Environ.Microbiol_70_7303
Author(s) : Brede DA , Faye T , Johnsborg O , Odegard I , Nes IF , Holo H
Ref : Applied Environmental Microbiology , 70 :7303 , 2004
PubMedID: 15574930
Gene_locus related to this paper: 9acto-q6e3k7

Title : Novel inhibitor for prolyl aminopeptidase from Serratia marcescens and studies on the mechanism of substrate recognition of the enzyme using the inhibitor - Inoue_2003_Arch.Biochem.Biophys_416_147
Author(s) : Inoue T , Ito K , Tozaka T , Hatakeyama S , Tanaka N , Nakamura KT , Yoshimoto T
Ref : Archives of Biochemistry & Biophysics , 416 :147 , 2003
PubMedID: 12893291
Gene_locus related to this paper: serma-impep

Title : Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism - Goettig_2002_Embo.J_21_5343
Author(s) : Goettig P , Groll M , Kim JS , Huber R , Brandstetter H
Ref : EMBO Journal , 21 :5343 , 2002
PubMedID: 12374735
Gene_locus related to this paper: theac-pip

Title : Crystal structure of prolyl aminopeptidase from Serratia marcescens - Yoshimoto_1999_J.Biochem_126_559
Author(s) : Yoshimoto T , Kabashima T , Uchikawa K , Inoue T , Tanaka N , Nakamura KT , Tsuru M , Ito K
Ref : J Biochem , 126 :559 , 1999
PubMedID: 10467172
Gene_locus related to this paper: serma-impep

Title : Structure of proline iminopeptidase from Xanthomonas campestris pv. citri: a prototype for the prolyl oligopeptidase family - Medrano_1998_EMBO.J_17_1
Author(s) : Medrano FJ , Alonso J , Garcia JL , Romero A , Bode W , Gomis-Ruth FX
Ref : EMBO Journal , 17 :1 , 1998
PubMedID: 9427736
Gene_locus related to this paper: xanca-impep

Title : Tricorn protease (TRI) interacting factor 1 from Thermoplasma acidophilum is a proline iminopeptidase - Tamura_1996_FEBS.Lett_398_101
Author(s) : Tamura T , Tamura N , Lottspeich F , Baumeister W
Ref : FEBS Letters , 398 :101 , 1996
PubMedID: 8946961
Gene_locus related to this paper: theac-pip