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Inhibitor Report for: Pancuronium

Myorelaxant close to Parquat . Ligand of small conductance Ca2+-activated K+ (SKca) channels


General
Type Nicotinic antagonist, Neuromuscular Nondepolarizing Agents, Not A/B H target, Aminosteroid
Chemical_Nomenclature 1,1'-[(2beta,3alpha,5alpha16beta,17beta)-3, 17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methylpiperidinium]
Canonical SMILES CC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
InChI InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
InChIKey NPIJXCQZLFKBMV-YTGGZNJNSA-L
Other name(s) Pavulon ; pancuronium bromide
________________________________________________________________________________________________
MW|732.7
Formula|C35H60N2O4Br2
CAS_number|15500-66-0
PubChem|27350
UniChem|NPIJXCQZLFKBMV-YTGGZNJNSA-L
IUPHAR|4001
Wikipedia|Pancuronium_bromide

Target
Families | Pancuronium ligand of proteins in family: BCHE

References:
Search PubMed for references concerning: Pancuronium

7 more
    Title: [Profile of the effect of succinylcholine after pre-curarization with atracurium, vecuronium or pancuronium]
    Ebeling BJ, Keienburg T, Hausmann D, Apffelstaedt C
    Ref: Anasthesiol Intensivmed Notfallmed Schmerzther, 31:304, 1996 : PubMed

            

    Title: Differential inhibition of plasma cholinesterase variants using the dibutyrate analogue of pancuronium bromide
    Whittaker M, Britten JJ
    Ref: Hum Hered, 31:242, 1981 : PubMed

            

    Title: The activity of various esterase inhibitors towards atypical human serum cholinesterase
    Kalow W, Davies R0
    Ref: Biochemical Pharmacology, 1:183, 1958 : PubMed

            


human-BCHE
MutationKiKsiIc50SubstrateConditionPaper
D70G - - 22 uM   Lockridge_1990_Pharmacol.Ther_47_35
WT - - 0.15 uM   Lockridge_1990_Pharmacol.Ther_47_35

WT Kinetics
Kinetic parametersKiKsiIc50SubstrateConditionsPapers
human-BCHE--0.15 uM  Lockridge_1990_Pharmacol.Ther_47_35