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Inhibitor Report for: SMR000042088

SMR000042088 is reported as a brain-penetrating inhibitor of prolyl endopeptidase-like (PREPL) enzyme activity. It is a useful pharmacological tool for investigating the biochemistry and physiological function of PREPL.


General
Type Pyridine, Cyanide
Chemical_Nomenclature 1-(2-methylpropyl)-3-oxo-2,5,6,7-tetrahydrocyclopenta[c]pyridine-4-carbonitrile
Canonical SMILES CC(C)CC1=C2CCCC2=C(C(=O)N1)C#N
InChI InChI=1S/C13H16N2O/c1-8(2)6-12-10-5-3-4-9(10)11(7-14)13(16)15-12/h8H,3-6H2,1-2H3,(H,15,16)
InChIKey QOUMCRXJXXVERM-UHFFFAOYSA-N
Other name(s) compound 8 [PMID: 21692504] ; MLS000077901 ; STK649251 ; SR-01000002103 ; AC1LD5G0 ; Oprea1_077264
________________________________________________________________________________________________
MW|216.27
Formula|C13H16N2O
CAS_number|
PubChem|661524
UniChem|QOUMCRXJXXVERM-UHFFFAOYSA-N
IUPHAR|8491
Wikipedia|

Target
Families | SMR000042088 ligand of proteins in family: S9N_PREPL_Peptidase_S9
Protein | human-PREPL

References:
Search PubMed for references concerning: SMR000042088
    Title: Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function
    Rosier K, McDevitt MT, Smet J, Floyd BJ, Verschoore M, Marcaida MJ, Bingman CA, Lemmens I, Dal Peraro M and Creemers JWM <12 more author(s)>
    Ref: iScience, 24:103460, 2021 : PubMed

            

    Title: A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors
    Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H and Saghatelian A <1 more author(s)>
    Ref: Journal of the American Chemical Society, 133:11665, 2011 : PubMed