A280T_tetur-ACHE

General

Gene Locus : tetur-ACHE

Mode of mutation : Natural mutant

Disease :

Summary : OP-resistance Insecticide resistance Khajehali_2010_Pest.Manag.Sci_66_220 || OP-resistance Insecticide resistance Kwon_2010_Pestic.Biochem.Physiol_96_36 || OP-resistance Insecticide resistance, amplified allele Kwon_2010_Insect.Mol.Biol_19_195 || OP-resistance Insecticide resistance, amplified allele Kwon_2012_Insect.Biochem.Mol.Biol_42_212

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance

Torpedo_number : 280

Kinetic Parameter : No kinetic parameter

News : NOVEMBER-21-2009

Comment :
Khajehali et al. found this modification in all three OP strains but not all clones. This mutation does not seem to be responsible for the modification of the biochemical properties of AChE1. This residue is not conserved among species and both resistant and susceptible strains of T. urticae from Japan have a T at position 280. Kwon et al. present evidences that A280T reduce OP sensitivity of AChE and contribute to resistance. The amino acid substitution was modified accordingly in the database || AChE gene duplication results in the proportional overexpression which is necessary for the reduced catalytic activity caused by mutations || p.Ala280Thr

References (7)

Title : Geographical distribution and origin of acetylcholinesterase mutations conferring acaricide resistance in Tetranychus urticae populations from Turkey - Inak_2021_Exp.Appl.Acarol__
Author(s) : Inak E
Ref : Exp Appl Acarol , : , 2021
Abstract :
PubMedSearch : Inak_2021_Exp.Appl.Acarol__
PubMedID: 34731389

Title : Identification and characterization of striking multiple-insecticide resistance in a Tetranychus urticae field population from Greece - Papapostolou_2021_Pest.Manag.Sci_77_666
Author(s) : Papapostolou KM , Riga M , Charamis J , Skoufa E , Souchlas V , Ilias A , Dermauw W , Ioannidis P , Van Leeuwen T , Vontas J
Ref : Pest Manag Sci , 77 :666 , 2021
Abstract :
PubMedSearch : Papapostolou_2021_Pest.Manag.Sci_77_666
PubMedID: 33051974
Gene_locus related to this paper: tetur-ACHE

Title : Global distribution and origin of target site insecticide resistance mutations in Tetranychus urticae - Ilias_2014_Insect.Biochem.Mol.Biol_48_17
Author(s) : Ilias A , Vontas J , Tsagkarakou A
Ref : Insect Biochemistry & Molecular Biology , 48 :17 , 2014
Abstract :
PubMedSearch : Ilias_2014_Insect.Biochem.Mol.Biol_48_17
PubMedID: 24602758
Gene_locus related to this paper: tetur-ACHE

Title : The overexpression of acetylcholinesterase compensates for the reduced catalytic activity caused by resistance-conferring mutations in Tetranychus urticae - Kwon_2012_Insect.Biochem.Mol.Biol_42_212
Author(s) : Kwon DH , Choi JY , Je YH , Lee SH
Ref : Insect Biochemistry & Molecular Biology , 42 :212 , 2012
Abstract :
PubMedSearch : Kwon_2012_Insect.Biochem.Mol.Biol_42_212
PubMedID: 22198354
Gene_locus related to this paper: tetur-ACHE

Title : Acetylcholinesterase point mutations putatively associated with monocrotophos resistance in the two-spotted spider mite - Kwon_2010_Pestic.Biochem.Physiol_96_36
Author(s) : Kwon DH , Im JS , Ahn JJ , Lee J-H , Clark JM , Lee SH
Ref : Pesticide Biochemistry and Physiology , 96 :36 , 2010
Abstract :
PubMedSearch : Kwon_2010_Pestic.Biochem.Physiol_96_36
PubMedID:
Gene_locus related to this paper: tetur-ACHE

Title : Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychidae) resistant to organophosphates - Khajehali_2010_Pest.Manag.Sci_66_220
Author(s) : Khajehali J , Van Leeuwen T , Grispou M , Morou E , Alout H , Weill M , Tirry L , Vontas J , Tsagkarakou A
Ref : Pest Manag Sci , 66 :220 , 2010
Abstract :
PubMedSearch : Khajehali_2010_Pest.Manag.Sci_66_220
PubMedID: 19894225
Gene_locus related to this paper: tetur-ACHE

Title : Extensive gene duplication of acetylcholinesterase associated with organophosphate resistance in the two-spotted spider mite - Kwon_2010_Insect.Mol.Biol_19_195
Author(s) : Kwon DH , Clark JM , Lee SH
Ref : Insect Molecular Biology , 19 :195 , 2010
Abstract :
PubMedSearch : Kwon_2010_Insect.Mol.Biol_19_195
PubMedID: 20002213
Gene_locus related to this paper: tetur-ACHE