Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Peripheral Anionic Site Peripheral Anionic Site\/signal transduction\/allosteric modulation. Affects conformation of active site and PAS Shafferman_1992_EMBO.J_11_3561 Shafferman_1992_4th.ChE.Meeting.Eilat__165 || Signal transduction Affects conformation of active site and PAS Shafferman_1992_EMBO.J_11_3561 Shafferman_1992_4th.ChE.Meeting.Eilat__165 || VX stereospecificity no effect in stereoselectivity Ordentlich_2005_Chem.Biol.Interact_157-158_191 || oxime interaction reactivation of tabun-inhibited human AChE. Unable to facilitate HI-6-mediated reactivation of tabun-hAChE Artursson_2009_Toxicology_265_108
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Peripheral Anionic Site || Substrate inhibition || Signal transduction || Allosteric modulation || Oxime interaction
Torpedo_number : 72
Kinetic Parameter : BW284C51_D74E_human-ACHE, Decamethonium_D74E_human-ACHE, Propidium_D74E_human-ACHE, Edrophonium_D74E_human-ACHE, Acetylthiocholine_D74E_human-ACHE
News : No news
Comment :
p.D74E Asp74Glu (p.D105E Asp105Glu in primary sequence with 31 amino-acids signal peptide) Peripheral Anionic Site\/signal transduction\/allosteric modulation. Affects conformation of active site and PAS\; no effect in VX stereoselectivity\; Unable to facilitate HI-6-mediated reactivation of tabun-hAChE
| Title : Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis - Artursson_2009_Toxicology_265_108 |
| Author(s) : Artursson E , Akfur C , Hornberg A , Worek F , Ekstrom F |
| Ref : Toxicology , 265 :108 , 2009 |
| Abstract : |
| PubMedSearch : Artursson_2009_Toxicology_265_108 |
| PubMedID: 19761810 |
| Title : The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers - Ordentlich_2005_Chem.Biol.Interact_157-158_191 |
| Author(s) : Ordentlich A , Barak D , Sod-Moriah G , Kaplan D , Mizrahi D , Segall Y , Kronman C , Karton Y , Lazar A , Marcus D , Velan B , Shafferman A |
| Ref : Chemico-Biological Interactions , 157-158 :191 , 2005 |
| Abstract : |
| PubMedSearch : Ordentlich_2005_Chem.Biol.Interact_157-158_191 |
| PubMedID: 16289014 |
| Title : Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center - Shafferman_1992_EMBO.J_11_3561 |
| Author(s) : Shafferman A , Velan B , Ordentlich A , Kronman C , Grosfeld H , Leitner M , Flashner Y , Cohen S , Barak D , Ariel N |
| Ref : EMBO Journal , 11 :3561 , 1992 |
| Abstract : |
| PubMedSearch : Shafferman_1992_EMBO.J_11_3561 |
| PubMedID: 1396557 |
| Title : Acetylcholinesterase Catalysis - Protein Engineering Studies - |
| Author(s) : Shafferman A , Velan B |
| Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :165 , 1992 |
| PubMedID: |