Worek F

General

Full name : Worek Franz

First name : Franz

Mail : Bundeswehr Institute of Pharmacology and Toxicology\; Neuherbergstrasse 11\; Munich\; 80937

Zip Code :

City :

Country : Germany

Email : franz.worek@lrz.uni-muenchen.de

Phone : +498931682930

Fax :

Website :

Directory :

References (220)

Title : Suitability of human HepaRG cells and liver spheroids as in vitro model to investigate the bioactivation of the organothiophosphate pesticide parathion - Horn_2024_Toxicol.In.Vitro_97_105811
Author(s) : Horn G , Worek F
Ref : Toxicol In Vitro , 97 :105811 , 2024
PubMedID: 38521251

Title : Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication - Gorecki_2024_Chem.Biol.Interact__110941
Author(s) : Gorecki L , Markova A , Hepnarova V , Zivna N , Junova L , Hrabinova M , Janousek J , Kobrlova T , Prchal L , Jun D , Soukup O , Horn G , Worek F , Marek J , Korabecny J
Ref : Chemico-Biological Interactions , :110941 , 2024
PubMedID: 38493910

Title : Inhibition kinetics of acetylcholinesterase and butyrylcholinesterase from various species by 2-(2-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) - Horn_2024_Toxicol.Lett_396_28
Author(s) : Horn G , Rappengluck S , Worek F
Ref : Toxicol Lett , 396 :28 , 2024
PubMedID: 38642675

Title : Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes - Structure-activity relationships - Amend_2024_Toxicology__153741
Author(s) : Amend N , Timperley CM , Bird M , Green AC , Worek F , Seeger T
Ref : Toxicology , :153741 , 2024
PubMedID: 38311098

Title : MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor - Nitsche_2024_Toxicol.Lett_392_94
Author(s) : Nitsche V , Hofner G , Kaiser J , Gertzen CGW , Seeger T , Niessen KV , Steinritz D , Worek F , Gohlke H , Paintner FF , Wanner KT
Ref : Toxicol Lett , 392 :94 , 2024
PubMedID: 38216073

Title : Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor - Sichler_2024_Toxicol.Lett_394_23
Author(s) : Sichler S , Hofner G , Nitsche V , Niessen KV , Seeger T , Worek F , Paintner FF , Wanner KT
Ref : Toxicol Lett , 394 :23 , 2024
PubMedID: 38387764

Title : The use of bispyridinium non-oxime analogues for the restoration of nerve agent impaired neuromuscular transmission in rat hemidiaphragms - Structure optimization - Amend_2024_Toxicol.Lett__
Author(s) : Amend N , Timperley CM , Bird M , Green AC , Worek F , Seeger T
Ref : Toxicol Lett , : , 2024
PubMedID: 38723915

Title : AChE reactivation in Precision-cut lung slices following organophosphorus compound poisoning - Golitz_2023_Toxicol.Lett__
Author(s) : Golitz F , Herbert J , Worek F , Wille T
Ref : Toxicol Lett , : , 2023
PubMedID: 38160862

Title : A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment - Kaiser_2023_Toxicol.Lett_373_160
Author(s) : Kaiser J , Gertzen CGW , Bernauer T , Hofner G , Niessen KV , Seeger T , Paintner FF , Wanner KT , Worek F , Thiermann H , Gohlke H
Ref : Toxicol Lett , 373 :160 , 2023
PubMedID: 36503818

Title : A case report of severe pirimiphos-methyl intoxication: Clinical findings and cholinesterase status - Zellner_2022_Front.Pharmacol_13_1102160
Author(s) : Zellner T , Rabe C , von der Wellen-Pawlowski J , Hansen D , John H , Worek F , Eyer F
Ref : Front Pharmacol , 13 :1102160 , 2022
PubMedID: 36618943

Title : Broad-spectrum antidote discovery by untangling the reactivation mechanism of nerve agent inhibited acetylcholinesterase - Lindgren_2022_Chemistry_28_e202200678
Author(s) : Lindgren C , Forsgren N , Hoster N , Akfur C , Artursson E , Edvinsson L , Svensson R , Worek F , Ekstrom , Linusson A
Ref : Chemistry , 28 :e202200678 , 2022
PubMedID: 35420233
Gene_locus related to this paper: mouse-ACHE

Title : Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro - Horn_2022_Chem.Biol.Interact__110285
Author(s) : Horn G , Kranawetvogl T , John H , Weigel C , Rauen U , Worek F , Wille T
Ref : Chemico-Biological Interactions , :110285 , 2022
PubMedID: 36442613

Title : Oximes should be used routinely in organophosphate poisoning - Thiermann_2022_Br.J.Clin.Pharmacol__
Author(s) : Thiermann H , Worek F
Ref : British Journal of Clinical Pharmacology , : , 2022
PubMedID: 35023196

Title : Organophosphorus pesticides exhibit compound specific effects in rat precision-cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative defense - Tigges_2021_Arch.Toxicol__
Author(s) : Tigges J , Worek F , Thiermann H , Wille T
Ref : Archives of Toxicology , : , 2021
PubMedID: 34778934

Title : Release of protein-bound nerve agents by excess fluoride from whole blood: GC-MS\/MS method development, validation, and application to a real-life denatured blood sample - Koller_2021_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1179_122693
Author(s) : Koller M , Thiermann H , Worek F , Wille T
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1179 :122693 , 2021
PubMedID: 34171608

Title : Post-VX exposure treatment of rats with engineered phosphotriesterases - Stigler_2021_Arch.Toxicol__
Author(s) : Stigler L , Kohler A , Koller M , Job L , Escher B , Potschka H , Thiermann H , Skerra A , Worek F , Wille T
Ref : Archives of Toxicology , : , 2021
PubMedID: 34962578

Title : Development of versatile and potent monoquaternary reactivators of acetylcholinesterase - Gorecki_2021_Arch.Toxicol__
Author(s) : Gorecki L , Hepnarova V , Karasova JZ , Hrabinova M , Courageux C , Dias J , Kucera T , Kobrlova T , Muckova L , Prchal L , Malinak D , Jun D , Musilek K , Worek F , Nachon F , Soukup O , Korabecny J
Ref : Archives of Toxicology , : , 2021
PubMedID: 33517499

Title : Early diagnosis of nerve agent exposure with a mobile test kit and implications for medical countermeasures: a trigger to react - Wille_2020_BMJ.Mil.Health__
Author(s) : Wille T , Djordjevic S , Worek F , Thiermann H , Vucinic S
Ref : BMJ Mil Health , : , 2020
PubMedID: 32086265

Title : Organophosphorus compounds and oximes: a critical review - Worek_2020_Arch.Toxicol_94_2275
Author(s) : Worek F , Thiermann H , Wille T
Ref : Archives of Toxicology , 94 :2275 , 2020
PubMedID: 32506210

Title : A case report of cholinesterase inhibitor poisoning: cholinesterase activities and analytical methods for diagnosis and clinical decision making - Amend_2020_Arch.Toxicol__
Author(s) : Amend N , Langgartner J , Siegert M , Kranawetvogl T , Koller M , John H , Pflugler C , Mogele-Schmid C , Worek F , Thiermann H , Wille T
Ref : Archives of Toxicology , : , 2020
PubMedID: 32303803

Title : In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase - Worek_2020_Molecules_25_
Author(s) : Worek F , Thiermann H , Koller M , Wille T
Ref : Molecules , 25 : , 2020
PubMedID: 32630769

Title : Synthesis and in vitro evaluation of novel non-oximes for the reactivation of nerve agent inhibited human acetylcholinesterase - de Koning_2020_Chem.Biol.Interact__109139
Author(s) : De Koning MC , Horn G , Worek F , van Grol M
Ref : Chemico-Biological Interactions , :109139 , 2020
PubMedID: 32454005

Title : Diagnostics and treatment of nerve agent poisoning-current status and future developments - Amend_2020_Ann.N.Y.Acad.Sci__
Author(s) : Amend N , Niessen KV , Seeger T , Wille T , Worek F , Thiermann H
Ref : Annals of the New York Academy of Sciences , : , 2020
PubMedID: 32198755

Title : Human small bowel as model for poisoning with organophosphorus compounds - Marquart_2019_Toxicol.In.Vitro_57_76
Author(s) : Marquart K , Prokopchuk O , Wilhelm D , Worek F , Thiermann H , Martignoni ME , Wille T
Ref : Toxicol In Vitro , 57 :76 , 2019
PubMedID: 30763608

Title : COPD and asthma therapeutics for supportive treatment in organophosphate poisoning - Herbert_2019_Clin.Toxicol.(Phila)__1
Author(s) : Herbert J , Thiermann H , Worek F , Wille T
Ref : Clinical Toxicology (Phila) , :1 , 2019
PubMedID: 30696282

Title : The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM) - Amend_2019_Toxicol.Lett_308_1
Author(s) : Amend N , Thiermann H , Worek F , Wille T
Ref : Toxicol Lett , 308 :1 , 2019
PubMedID: 30858091

Title : New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling - Wein_2019_Curr.Comput.Aided.Drug.Des_15_104
Author(s) : Wein T , Wanner KT , Rappengluck S , Sichler S , Niessen KV , Seeger T , Worek F , Thiermann H
Ref : Curr Comput Aided Drug Des , 15 :104 , 2019
PubMedID: 29968541

Title : The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents - Vitorovic-Todorovic_2019_Chem.Biol.Interact_13ChEPon_309_108714
Author(s) : Vitorovic-Todorovic MD , Worek F , Perdih A , Bauk SD , Vujatovic TB , Cvijetic IN
Ref : Chemico-Biological Interactions , 309 :108714 , 2019
PubMedID: 31228470

Title : Efficacy of an organophosphorus hydrolase enzyme (OpdA) in human serum and minipig models of organophosphorus insecticide poisoning - Eddleston_2019_Clin.Toxicol.(Phila)__1
Author(s) : Eddleston M , Clutton RE , Taylor M , Thompson A , Worek F , John H , Thiermann H , Scott C
Ref : Clinical Toxicology (Phila) , :1 , 2019
PubMedID: 31452424

Title : Counteracting desensitization of human alpha7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning - Scheffel_2018_Toxicol.Lett_293_149
Author(s) : Scheffel C , Niessen KV , Rappengluck S , Wanner KT , Thiermann H , Worek F , Seeger T
Ref : Toxicol Lett , 293 :149 , 2018
PubMedID: 29248576

Title : Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman - Drexler_2018_Toxicol.Lett_297_19
Author(s) : Drexler B , Seeger T , Worek F , Thiermann H , Antkowiak B , Grasshoff C
Ref : Toxicol Lett , 297 :19 , 2018
PubMedID: 30165091

Title : Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human alpha7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis - Scheffel_2018_Toxicol.Lett_293_157
Author(s) : Scheffel C , Niessen KV , Rappengluck S , Wanner KT , Thiermann H , Worek F , Seeger T
Ref : Toxicol Lett , 293 :157 , 2018
PubMedID: 29191791

Title : Evaluation of the accuracy of ChE check mobile in measurement of acetylcholinesterase in pesticide poisoning - Shihana_2018_Clin.Toxicol.(Phila)__1
Author(s) : Shihana F , Worek F , Dassanayake GA , Rathgamage SH , Dhanarisi J , Buckley NA
Ref : Clinical Toxicology (Phila) , :1 , 2018
PubMedID: 30451024

Title : Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro - Horn_2018_Toxicol.Lett_299_218
Author(s) : Horn G , De Koning MC , van Grol M , Thiermann H , Worek F
Ref : Toxicol Lett , 299 :218 , 2018
PubMedID: 30312685

Title : Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor - Rappengluck_2018_ChemMedChem_13_2653
Author(s) : Rappengluck S , Sichler S , Hofner G , Wein T , Niessen KV , Seeger T , Paintner FF , Worek F , Thiermann H , Wanner KT
Ref : ChemMedChem , 13 :2653 , 2018
PubMedID: 30362667

Title : Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor - Rappengluck_2018_ChemMedChem_13_1806
Author(s) : Rappengluck S , Sichler S , Hofner G , Wein T , Niessen KV , Seeger T , Paintner FF , Worek F , Thiermann H , Wanner KT
Ref : ChemMedChem , 13 :1806 , 2018
PubMedID: 29974635

Title : Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats - Marquart_2018_Clin.Toxicol.(Phila)__1
Author(s) : Marquart K , Herbert J , Amend N , Thiermann H , Worek F , Wille T
Ref : Clinical Toxicology (Phila) , :1 , 2018
PubMedID: 30307341

Title : In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers - Niessen_2018_Toxicol.Lett_293_190
Author(s) : Niessen KV , Seeger T , Rappengluck S , Wein T , Hofner G , Wanner KT , Thiermann H , Worek F
Ref : Toxicol Lett , 293 :190 , 2018
PubMedID: 29024789

Title : Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase - de Koning_2018_Eur.J.Med.Chem_157_151
Author(s) : De Koning MC , Horn G , Worek F , van Grol M
Ref : Eur Journal of Medicinal Chemistry , 157 :151 , 2018
PubMedID: 30096649

Title : Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network - John_2018_Forensic.Toxicol_36_61
Author(s) : John H , van der Schans MJ , Koller M , Spruit HET , Worek F , Thiermann H , Noort D
Ref : Forensic Toxicol , 36 :61 , 2018
PubMedID: 29367863

Title : Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor - Sichler_2018_Toxicol.Lett_293_172
Author(s) : Sichler S , Hofner G , Rappengluck S , Wein T , Niessen KV , Seeger T , Worek F , Thiermann H , Paintner FF , Wanner KT
Ref : Toxicol Lett , 293 :172 , 2018
PubMedID: 29146291

Title : Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning - Marquart_2018_Toxicol.Lett_293_235
Author(s) : Marquart K , Prokopchuk O , Worek F , Thiermann H , Martignoni ME , Wille T
Ref : Toxicol Lett , 293 :235 , 2018
PubMedID: 29154801

Title : Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor - Wein_2018_Toxicol.Lett_293_184
Author(s) : Wein T , Hofner G , Rappengluck S , Sichler S , Niessen KV , Seeger T , Worek F , Thiermann H , Wanner KT
Ref : Toxicol Lett , 293 :184 , 2018
PubMedID: 29097222

Title : Innovative Biocatalysts as Tools to Detect and Inactivate Nerve Agents - Porzio_2018_Sci.Rep_8_13773
Author(s) : Porzio E , Bettazzi F , Mandrich L , Del Giudice I , Restaino OF , Laschi S , Febbraio F , De Luca V , Borzacchiello MG , Carusone TM , Worek F , Pisanti A , Porcaro P , Schiraldi C , De Rosa M , Palchetti I , Manco G
Ref : Sci Rep , 8 :13773 , 2018
PubMedID: 30214052

Title : The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study - Worek_2018_Toxicol.Lett_293_216
Author(s) : Worek F , Thiermann H , Wille T
Ref : Toxicol Lett , 293 :216 , 2018
PubMedID: 28993240

Title : Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase - de Koning_2017_J.Med.Chem_60_9376
Author(s) : De Koning MC , Joosen MJ , Worek F , Nachon F , van Grol M , Klaassen SD , Alkema DPW , Wille T , de Bruijn HM
Ref : Journal of Medicinal Chemistry , 60 :9376 , 2017
PubMedID: 29091431

Title : An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet - Allgardsson_2017_Molecules_22_
Author(s) : Allgardsson A , David Andersson C , Akfur C , Worek F , Linusson A , Ekstrom F
Ref : Molecules , 22 : , 2017
PubMedID: 28867801
Gene_locus related to this paper: mouse-ACHE

Title : Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6 - Wille_2017_Arch.Toxicol_91_1309
Author(s) : Wille T , von der Wellen J , Thiermann H , Worek F
Ref : Archives of Toxicology , 91 :1309 , 2017
PubMedID: 27358236

Title : In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications - Ashani_2016_Chem.Biol.Interact_259_252
Author(s) : Ashani Y , Leader H , Aggarwal N , Silman I , Worek F , Sussman JL , Goldsmith M
Ref : Chemico-Biological Interactions , 259 :252 , 2016
PubMedID: 27163850

Title : Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report - Steinritz_2016_Toxicol.Lett_244_121
Author(s) : Steinritz D , Eyer F , Worek F , Thiermann H , John H
Ref : Toxicol Lett , 244 :121 , 2016
PubMedID: 26200596

Title : Kinetics of pesticide degradation by human fresh frozen plasma (FFP) in vitro - von der Wellen_2016_Toxicol.Lett_244_124
Author(s) : von der Wellen J , Bierwisch A , Worek F , Thiermann H , Wille T
Ref : Toxicol Lett , 244 :124 , 2016
PubMedID: 26220518

Title : Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase - Winter_2016_Toxicol.Lett_244_136
Author(s) : Winter M , Wille T , Musilek K , Kuca K , Thiermann H , Worek F
Ref : Toxicol Lett , 244 :136 , 2016
PubMedID: 26210933

Title : An efficient thermostable organophosphate hydrolase and its application in pesticide decontamination - Del Giudice_2016_Biotechnol.Bioeng_113_724
Author(s) : Del Giudice I , Coppolecchia R , Merone L , Porzio E , Carusone TM , Mandrich L , Worek F , Manco G
Ref : Biotechnol Bioeng , 113 :724 , 2016
PubMedID: 26416557

Title : On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit-Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds - Worek_2016_Toxicol.Lett_249_22
Author(s) : Worek F , Schilha M , Neumaier K , Aurbek N , Wille T , Thiermann H , Kehe K
Ref : Toxicol Lett , 249 :22 , 2016
PubMedID: 27033775

Title : Catalytic bioscavengers in nerve agent poisoning: A promising approach? - Worek_2016_Toxicol.Lett_244_143
Author(s) : Worek F , Thiermann H , Wille T
Ref : Toxicol Lett , 244 :143 , 2016
PubMedID: 26200600

Title : Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro - Goldsmith_2016_Arch.Toxicol_90_2711
Author(s) : Goldsmith M , Eckstein S , Ashani Y , Greisen P, Jr. , Leader H , Sussman JL , Aggarwal N , Ovchinnikov S , Tawfik DS , Baker D , Thiermann H , Worek F
Ref : Archives of Toxicology , 90 :2711 , 2016
PubMedID: 26612364

Title : Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds - Bierwisch_2016_Toxicol.Lett_246_49
Author(s) : Bierwisch A , Wille T , Thiermann H , Worek F
Ref : Toxicol Lett , 246 :49 , 2016
PubMedID: 26851641

Title : Oximes in organophosphate poisoning: 60 years of hope and despair - Worek_2016_Chem.Biol.Interact_259_93
Author(s) : Worek F , Thiermann H , Wille T
Ref : Chemico-Biological Interactions , 259 :93 , 2016
PubMedID: 27125761

Title : Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study - Worek_2016_Toxicol.Lett_262_12
Author(s) : Worek F , Seeger T , Neumaier K , Wille T , Thiermann H
Ref : Toxicol Lett , 262 :12 , 2016
PubMedID: 27639501

Title : Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology - Niessen_2016_Toxicol.Lett_247_1
Author(s) : Niessen KV , Muschik S , Langguth F , Rappengluck S , Seeger T , Thiermann H , Worek F
Ref : Toxicol Lett , 247 :1 , 2016
PubMedID: 26851639

Title : Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6 - Allgardsson_2016_Proc.Natl.Acad.Sci.U.S.A_113_5514
Author(s) : Allgardsson A , Berg L , Akfur C , Hornberg A , Worek F , Linusson A , Ekstrom F
Ref : Proc Natl Acad Sci U S A , 113 :5514 , 2016
PubMedID: 27140636
Gene_locus related to this paper: human-ACHE

Title : Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection - Wille_2016_Toxicol.Lett_258_198
Author(s) : Wille T , Neumaier K , Koller M , Ehinger C , Aggarwal N , Ashani Y , Goldsmith M , Sussman JL , Tawfik DS , Thiermann H , Worek F
Ref : Toxicol Lett , 258 :198 , 2016
PubMedID: 27397758

Title : Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics - Worek_2016_Toxicology_350-352_25
Author(s) : Worek F , Koller M , Thiermann H , Wille T
Ref : Toxicology , 350-352 :25 , 2016
PubMedID: 27153754

Title : Application of a dynamic in vitro model with real-time determination of acetylcholinesterase activity for the investigation of tabun analogues and oximes - Worek_2015_Toxicol.In.Vitro_30_514
Author(s) : Worek F , Herkert NM , Koller M , Thiermann H , Wille T
Ref : Toxicol In Vitro , 30 :514 , 2015
PubMedID: 26368669

Title : In vitro and in vivo toxicological studies of V nerve agents: molecular and stereoselective aspects - Reiter_2015_Toxicol.Lett_232_438
Author(s) : Reiter G , Muller S , Hill I , Weatherby K , Thiermann H , Worek F , Mikler J
Ref : Toxicol Lett , 232 :438 , 2015
PubMedID: 25448275

Title : Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase - Scheffel_2015_Toxicol.Lett_232_557
Author(s) : Scheffel C , Thiermann H , Worek F
Ref : Toxicol Lett , 232 :557 , 2015
PubMedID: 25522658

Title : Small-scale purification of butyrylcholinesterase from human plasma and implementation of a muLC-UV\/ESI MS\/MS method to detect its organophosphorus adducts - John_2015_Drug.Test.Anal_7_947
Author(s) : John H , Breyer F , Schmidt C , Mizaikoff B , Worek F , Thiermann H
Ref : Drug Test Anal , 7 :947 , 2015
PubMedID: 25828536

Title : Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase - Horn_2015_Arch.Toxicol_89_405
Author(s) : Horn G , Wille T , Musilek K , Kuca K , Thiermann H , Worek F
Ref : Archives of Toxicology , 89 :405 , 2015
PubMedID: 24912784

Title : Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines - Ring_2015_PLoS.One_10_e0135811
Author(s) : Ring A , Strom BO , Turner SR , Timperley CM , Bird M , Green AC , Chad JE , Worek F , Tattersall JE
Ref : PLoS ONE , 10 :e0135811 , 2015
PubMedID: 26274808

Title : Freeze-drying of HI-6-loaded recombinant human serum albumin nanoparticles for improved storage stability - Dadparvar_2014_Eur.J.Pharm.Biopharm_88_510
Author(s) : Dadparvar M , Wagner S , Wien S , Worek F , von Briesen H , Kreuter J
Ref : Eur J Pharm Biopharm , 88 :510 , 2014
PubMedID: 24995841

Title : V-type nerve agents phosphonylate ubiquitin at biologically relevant lysine residues and induce intramolecular cyclization by an isopeptide bond - Schmidt_2014_Anal.Bioanal.Chem_406_5171
Author(s) : Schmidt C , Breyer F , Blum MM , Thiermann H , Worek F , John H
Ref : Anal Bioanal Chem , 406 :5171 , 2014
PubMedID: 24652148

Title : Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study - Worek_2014_Toxicol.Lett_231_45
Author(s) : Worek F , Seeger T , Reiter G , Goldsmith M , Ashani Y , Leader H , Sussman JL , Aggarwal N , Thiermann H , Tawfik DS
Ref : Toxicol Lett , 231 :45 , 2014
PubMedID: 25195526

Title : In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP) - Wille_2014_Arch.Toxicol_88_301
Author(s) : Wille T , Thiermann H , Worek F
Ref : Archives of Toxicology , 88 :301 , 2014
PubMedID: 24057572

Title : Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro - Worek_2014_Arch.Toxicol_88_1257
Author(s) : Worek F , Seeger T , Goldsmith M , Ashani Y , Leader H , Sussman JL , Tawfik DS , Thiermann H , Wille T
Ref : Archives of Toxicology , 88 :1257 , 2014
PubMedID: 24477626

Title : Effectiveness of a substituted beta-cyclodextrin to prevent cyclosarin toxicity in vivo - Worek_2014_Toxicol.Lett_226_222
Author(s) : Worek F , Seeger T , Zengerle M , Kubik S , Thiermann H , Wille T
Ref : Toxicol Lett , 226 :222 , 2014
PubMedID: 24561299

Title : Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes - Possible therapeutic implications - Worek_2014_Toxicol.Lett_231_92
Author(s) : Worek F , Elsinghorst P , Koller M , Thiermann H
Ref : Toxicol Lett , 231 :92 , 2014
PubMedID: 25240274

Title : Adaptation of a dynamic in vitro model with real-time determination of butyrylcholinesterase activity in the presence of cyclosarin and an oxime - Worek_2014_Toxicol.In.Vitro_29_162
Author(s) : Worek F , Horn G , Wille T , Thiermann H
Ref : Toxicol In Vitro , 29 :162 , 2014
PubMedID: 25450746

Title : Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length - Niessen_2013_Chem.Biol.Interact_206_545
Author(s) : Niessen KV , Seeger T , Tattersall JE , Timperley CM , Bird M , Green C , Thiermann H , Worek F
Ref : Chemico-Biological Interactions , 206 :545 , 2013
PubMedID: 24157926

Title : The value of novel oximes for treatment of poisoning by organophosphorus compounds - Worek_2013_Pharmacol.Ther_139_249
Author(s) : Worek F , Thiermann H
Ref : Pharmacol Ther , 139 :249 , 2013
PubMedID: 23603539

Title : Functionalized cyclodextrins bearing an alpha nucleophile - A promising way to degrade nerve agents - Estour_2013_Chem.Biol.Interact_203_202
Author(s) : Estour F , Letort S , Muller S , Kalakuntla RK , Le Provost R , Wille T , Reiter G , Worek F , Lafont O , Gouhier G
Ref : Chemico-Biological Interactions , 203 :202 , 2013
PubMedID: 23123247

Title : Reactivation of Plasma Butyrylcholinesterase by Pralidoxime Chloride in Patients Poisoned by WHO Class II Toxicity Organophosphorus Insecticides - Konickx_2013_Toxicol.Sci_136_274
Author(s) : Konickx LA , Worek F , Jayamanne S , Thiermann H , Buckley NA , Eddleston M
Ref : Toxicol Sci , 136 :274 , 2013
PubMedID: 24052565

Title : New modified beta-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: Evaluation of the detoxification using a half-quantitative enzymatic assay - Kalakuntla_2013_Toxicol.Lett_216_200
Author(s) : Kalakuntla RK , Wille T , Le Provost R , Letort S , Reiter G , Muller S , Thiermann H , Worek F , Gouhier G , Lafont O , Estour F
Ref : Toxicol Lett , 216 :200 , 2013
PubMedID: 23201439

Title : Fourteenth International Medical Chemical Defence Conference 2013 Translation of experimental research for improved treatment of chemical warfare agents -
Author(s) : Wille T , Worek F , Thiermann H
Ref : Chemico-Biological Interactions , 206 :433 , 2013
PubMedID: 23920049

Title : Investigations of kinetic interactions between lipid emulsions, hydroxyethyl starch or dextran and organophosphorus compounds - Von Der Wellen_2013_Clin.Toxicol.(Phila)_51_918
Author(s) : von der Wellen J , Worek F , Thiermann H , Wille T
Ref : Clinical Toxicology (Phila) , 51 :918 , 2013
PubMedID: 24199642

Title : Structural requirements for effective oximes - Evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes - Worek_2013_Chem.Biol.Interact_203_125
Author(s) : Worek F , Wille T , Koller M , Thiermann H
Ref : Chemico-Biological Interactions , 203 :125 , 2013
PubMedID: 22827894

Title : Limitations and challenges in treatment of acute chemical warfare agent poisoning - Thiermann_2013_Chem.Biol.Interact_206_435
Author(s) : Thiermann H , Worek F , Kehe K
Ref : Chemico-Biological Interactions , 206 :435 , 2013
PubMedID: 24091052

Title : Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates - Wille_2013_Chem.Biol.Interact_206_569
Author(s) : Wille T , Kaltenbach L , Thiermann H , Worek F
Ref : Chemico-Biological Interactions , 206 :569 , 2013
PubMedID: 23962483

Title : Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ) - Niessen_2012_Drug.Test.Anal_4_292
Author(s) : Niessen KV , Tattersall JE , Timperley CM , Bird M , Green C , Thiermann H , Worek F
Ref : Drug Test Anal , 4 :292 , 2012
PubMedID: 22362630

Title : Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase - Herkert_2012_Toxicol.Lett_209_173
Author(s) : Herkert NM , Freude G , Kunz U , Thiermann H , Worek F
Ref : Toxicol Lett , 209 :173 , 2012
PubMedID: 22230262

Title : Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships - Worek_2012_Biochem.Pharmacol_83_1700
Author(s) : Worek F , Wille T , Koller M , Thiermann H
Ref : Biochemical Pharmacology , 83 :1700 , 2012
PubMedID: 22649796

Title : Detoxification of tabun at physiological pH mediated by substituted beta-cyclodextrin and glucose derivatives containing oxime groups - Brandhuber_2012_Toxicology_302_163
Author(s) : Brandhuber F , Zengerle M , Porwol L , Tenberken O , Thiermann H , Worek F , Kubik S , Reiter G
Ref : Toxicology , 302 :163 , 2012
PubMedID: 22982866

Title : Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning - Worek_2012_Drug.Test.Anal_4_282
Author(s) : Worek F , Eyer P , Thiermann H
Ref : Drug Test Anal , 4 :282 , 2012
PubMedID: 21998030

Title : Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase - Worek_2012_Arch.Toxicol_86_1379
Author(s) : Worek F , von der Wellen J , Musilek K , Kuca K , Thiermann H
Ref : Archives of Toxicology , 86 :1379 , 2012
PubMedID: 22437842

Title : Application of an enantioselective LC-ESI MS\/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine - John_2012_Drug.Test.Anal_4_194
Author(s) : John H , Mikler J , Worek F , Thiermann H
Ref : Drug Test Anal , 4 :194 , 2012
PubMedID: 21964777

Title : Photostability of antidotal oxime HI-6, impact on drug development - Bogan_2012_Drug.Test.Anal_4_208
Author(s) : Bogan R , Worek F , Koller M , Klaubert B
Ref : Drug Test Anal , 4 :208 , 2012
PubMedID: 22359386

Title : Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig - John_2012_Drug.Test.Anal_4_169
Author(s) : John H , Eddleston M , Eddie Clutton R , Worek F , Thiermann H
Ref : Drug Test Anal , 4 :169 , 2012
PubMedID: 22102522

Title : Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro - Seeger_2012_Toxicology_294_80
Author(s) : Seeger T , Eichhorn M , Lindner M , Niessen KV , Tattersall JE , Timperley CM , Bird M , Green AC , Thiermann H , Worek F
Ref : Toxicology , 294 :80 , 2012
PubMedID: 22349640

Title : A role for solvents in the toxicity of agricultural organophosphorus pesticides - Eddleston_2012_Toxicology_294_94
Author(s) : Eddleston M , Street JM , Self I , Thompson A , King T , Williams N , Naredo G , Dissanayake K , Yu LM , Worek F , John H , Smith S , Thiermann H , Harris JB , Eddie Clutton R
Ref : Toxicology , 294 :94 , 2012
PubMedID: 22365945

Title : In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases - Response to the letter to the editor -
Author(s) : Wille T , Thiermann H , Worek F
Ref : Chemico-Biological Interactions , 193 :108 , 2011
PubMedID:

Title : Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies - Reiter_2011_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_879_2704
Author(s) : Reiter G , Mikler J , Hill I , Weatherby K , Thiermann H , Worek F
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 879 :2704 , 2011
PubMedID: 21862421

Title : In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species - Herkert_2011_Toxicol.Lett_206_41
Author(s) : Herkert NM , Thiermann H , Worek F
Ref : Toxicol Lett , 206 :41 , 2011
PubMedID: 21414391

Title : Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase - Worek_2011_Toxicol.Lett_200_19
Author(s) : Worek F , Aurbek N , Wille T , Eyer P , Thiermann H
Ref : Toxicol Lett , 200 :19 , 2011
PubMedID: 20971170

Title : Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach - Worek_2011_J.Enzyme.Inhib.Med.Chem_26_303
Author(s) : Worek F , Aurbek N , Wille T , Eyer P , Thiermann H
Ref : J Enzyme Inhib Med Chem , 26 :303 , 2011
PubMedID: 20807085

Title : HI 6 human serum albumin nanoparticles--development and transport over an in vitro blood-brain barrier model - Dadparvar_2011_Toxicol.Lett_206_60
Author(s) : Dadparvar M , Wagner S , Wien S , Kufleitner J , Worek F , von Briesen H , Kreuter J
Ref : Toxicol Lett , 206 :60 , 2011
PubMedID: 21726608

Title : Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species - Wille_2011_Toxicol.Mech.Methods_21_533
Author(s) : Wille T , Thiermann H , Worek F
Ref : Toxicol Mech Methods , 21 :533 , 2011
PubMedID: 21470076

Title : The therapeutic use of localized cooling in the treatment of VX poisoning - Sawyer_2011_Toxicol.Lett_204_52
Author(s) : Sawyer TW , Mikler J , Worek F , Reiter G , Thiermann H , Tenn C , Weatherby K , Bohnert S
Ref : Toxicol Lett , 204 :52 , 2011
PubMedID: 21530621

Title : Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat - Klein-Rodewald_2011_Toxicol.Lett_206_94
Author(s) : Klein-Rodewald T , Seeger T , Dutschmann M , Worek F , Morschel M
Ref : Toxicol Lett , 206 :94 , 2011
PubMedID: 21767620

Title : Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures - Mikler_2011_Toxicol.Lett_206_47
Author(s) : Mikler J , Tenn C , Worek F , Reiter G , Thiermann H , Garrett M , Bohnert S , Sawyer TW
Ref : Toxicol Lett , 206 :47 , 2011
PubMedID: 21704135

Title : Optimized strategies to synthesize beta-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers - Le Provost_2011_Org.Biomol.Chem_9_3026
Author(s) : Le Provost R , Wille T , Louise L , Masurier N , Muller S , Reiter G , Renard PY , Lafont O , Worek F , Estour F
Ref : Org Biomol Chem , 9 :3026 , 2011
PubMedID: 21373706

Title : Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis - Worek_2011_Chem.Biol.Interact_194_91
Author(s) : Worek F , Thiermann H
Ref : Chemico-Biological Interactions , 194 :91 , 2011
PubMedID: 21930118

Title : Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6 - Seeger_2011_Toxicol.Lett_206_72
Author(s) : Seeger T , Niessen KV , Langer P , Gerhardus J , Worek F , Friess H , Bumm R , Mihaljevic AL , Thiermann H
Ref : Toxicol Lett , 206 :72 , 2011
PubMedID: 21803135

Title : Thirteenth International Medical Chemical Defence Conference 2011 New developments in the treatment of intoxications by chemical warfare agents with focus on neurotoxic agents -
Author(s) : Tenberken O , Worek F , Thiermann H
Ref : Toxicol Lett , 206 :3 , 2011
PubMedID: 21605643

Title : Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning - Thiermann_2011_Toxicol.Lett_206_77
Author(s) : Thiermann H , Steinritz D , Worek F , Radtke M , Eyer P , Eyer F , Felgenhauer N , Zilker T
Ref : Toxicol Lett , 206 :77 , 2011
PubMedID: 21771644

Title : In vitro detoxification of cyclosarin (GF) by modified cyclodextrins - Muller_2011_Toxicol.Lett_200_53
Author(s) : Muller S , Koller M , Le Provost R , Lafont O , Estour F , Wille T , Thiermann H , Worek F , Reiter G
Ref : Toxicol Lett , 200 :53 , 2011
PubMedID: 21035528

Title : Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro - Herkert_2011_Toxicol.Appl.Pharmacol_253_7
Author(s) : Herkert NM , Schulz S , Wille T , Thiermann H , Hatz RA , Worek F
Ref : Toxicol Appl Pharmacol , 253 :7 , 2011
PubMedID: 21402092

Title : Highly efficient cyclosarin degradation mediated by a beta-cyclodextrin derivative containing an oxime-derived substituent - Zengerle_2011_Beilstein.J.Org.Chem_7_1543
Author(s) : Zengerle M , Brandhuber F , Schneider C , Worek F , Reiter G , Kubik S
Ref : Beilstein J Org Chem , 7 :1543 , 2011
PubMedID: 22238531

Title : Interaction of bispyridinium compounds with the orthosteric binding site of human alpha7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs) - Niessen_2011_Toxicol.Lett_206_100
Author(s) : Niessen KV , Tattersall JE , Timperley CM , Bird M , Green C , Seeger T , Thiermann H , Worek F
Ref : Toxicol Lett , 206 :100 , 2011
PubMedID: 21703337

Title : Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning - Rajapakse_2011_Ann.Emerg.Med_58_559
Author(s) : Rajapakse BN , Thiermann H , Eyer P , Worek F , Bowe SJ , Dawson AH , Buckley NA
Ref : Annals of Emergency Medicine , 58 :559 , 2011
PubMedID: 22098995

Title : In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases - Wille_2011_Chem.Biol.Interact_190_79
Author(s) : Wille T , Thiermann H , Worek F
Ref : Chemico-Biological Interactions , 190 :79 , 2011
PubMedID: 21354413

Title : Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS\/MS and flow-injection-ESI-MS\/MS - John_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1234
Author(s) : John H , Eddleston M , Clutton RE , Worek F , Thiermann H
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 878 :1234 , 2010
PubMedID: 20106727

Title : Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations - Worek_2010_Chem.Biol.Interact_187_259
Author(s) : Worek F , Aurbek N , Herkert NM , John H , Eddleston M , Eyer P , Thiermann H
Ref : Chemico-Biological Interactions , 187 :259 , 2010
PubMedID: 19917271

Title : Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds - Wille_2010_Biochem.Pharmacol_80_941
Author(s) : Wille T , Ekstrom F , Lee JC , Pang YP , Thiermann H , Worek F
Ref : Biochemical Pharmacology , 80 :941 , 2010
PubMedID: 20510679

Title : Toxicokinetics of tabun enantiomers in anaesthetized swine after intravenous tabun administration - Tenberken_2010_Toxicol.Lett_198_177
Author(s) : Tenberken O , Mikler J , Hill I , Weatherby K , Thiermann H , Worek F , Reiter G
Ref : Toxicol Lett , 198 :177 , 2010
PubMedID: 20599598

Title : Nanoparticulate transport of oximes over an in vitro blood-brain barrier model - Wagner_2010_PLoS.One_5_e14213
Author(s) : Wagner S , Kufleitner J , Zensi A , Dadparvar M , Wien S , Bungert J , Vogel T , Worek F , Kreuter J , von Briesen H
Ref : PLoS ONE , 5 :e14213 , 2010
PubMedID: 21151975

Title : Chromatographic preparation and kinetic analysis of interactions between tabun enantiomers and acetylcholinesterase - Tenberken_2010_Toxicol.Lett_195_142
Author(s) : Tenberken O , Thiermann H , Worek F , Reiter G
Ref : Toxicol Lett , 195 :142 , 2010
PubMedID: 20347021

Title : Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach - Worek_2010_Toxicol.Appl.Pharmacol_249_231
Author(s) : Worek F , Wille T , Aurbek N , Eyer P , Thiermann H
Ref : Toxicol Appl Pharmacol , 249 :231 , 2010
PubMedID: 20888357

Title : Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship? - Aurbek_2010_Chem.Biol.Interact_187_215
Author(s) : Aurbek N , Herkert NM , Koller M , Thiermann H , Worek F
Ref : Chemico-Biological Interactions , 187 :215 , 2010
PubMedID: 20105433

Title : Development of a high-throughput screening for nerve agent detoxifying materials using a fully-automated robot-assisted biological assay - Wille_2010_Toxicol.In.Vitro_24_1026
Author(s) : Wille T , Thiermann H , Worek F
Ref : Toxicol In Vitro , 24 :1026 , 2010
PubMedID: 19961920

Title : Development and validation of a sensitive gas chromatography-ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of different species - Tenberken_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1290
Author(s) : Tenberken O , Worek F , Thiermann H , Reiter G
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 878 :1290 , 2010
PubMedID: 19766064

Title : Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase - Merone_2010_Bioresour.Technol_101_9204
Author(s) : Merone L , Mandrich L , Porzio E , Rossi M , Muller S , Reiter G , Worek F , Manco G
Ref : Bioresour Technol , 101 :9204 , 2010
PubMedID: 20667718

Title : Chromatographic analysis of toxic phosphylated oximes (POX): a brief overview - Becker_2010_Drug.Test.Anal_2_460
Author(s) : Becker C , Worek F , John H
Ref : Drug Test Anal , 2 :460 , 2010
PubMedID: 20882513

Title : Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning - Eyer_2010_Chem.Biol.Interact_187_270
Author(s) : Eyer P , Worek F , Thiermann H , Eddleston M
Ref : Chemico-Biological Interactions , 187 :270 , 2010
PubMedID: 19883634

Title : GC-MS and LC-MS analysis of nerve agents in body fluids: intra-laboratory verification test using spiked plasma and urine samples - Koller_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1226
Author(s) : Koller M , Becker C , Thiermann H , Worek F
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 878 :1226 , 2010
PubMedID: 20061191

Title : Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon - Herkert_2010_Toxicol.Lett_194_94
Author(s) : Herkert NM , Aurbek N , Eyer P , Thiermann H , Worek F
Ref : Toxicol Lett , 194 :94 , 2010
PubMedID: 20156534

Title : Aging mechanism of butyrylcholinesterase inhibited by an N-methyl analogue of tabun: implications of the trigonal-bipyramidal transition state rearrangement for the phosphylation or reactivation of cholinesterases - Nachon_2010_Chem.Biol.Interact_187_44
Author(s) : Nachon F , Carletti E , Worek F , Masson P
Ref : Chemico-Biological Interactions , 187 :44 , 2010
PubMedID: 20381476

Title : Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds - Thiermann_2010_Toxicol.Lett_197_236
Author(s) : Thiermann H , Eyer F , Felgenhauer N , Pfab R , Zilker T , Eyer P , Worek F
Ref : Toxicol Lett , 197 :236 , 2010
PubMedID: 20542100

Title : Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds - Thiermann_2010_Chem.Biol.Interact_187_265
Author(s) : Thiermann H , Seeger T , Gonder S , Herkert N , Antkowiak B , Zilker T , Eyer F , Worek F
Ref : Chemico-Biological Interactions , 187 :265 , 2010
PubMedID: 20036651

Title : Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro - Thiermann_2010_Toxicology_272_46
Author(s) : Thiermann H , Eyer P , Worek F
Ref : Toxicology , 272 :46 , 2010
PubMedID: 20385200

Title : Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients - Thiermann_2009_Toxicol.Lett_191_297
Author(s) : Thiermann H , Zilker T , Eyer F , Felgenhauer N , Eyer P , Worek F
Ref : Toxicol Lett , 191 :297 , 2009
PubMedID: 19793545

Title : Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study - Worek_2009_Toxicol.Lett_187_119
Author(s) : Worek F , Herkert NM , Koller M , Aurbek N , Thiermann H
Ref : Toxicol Lett , 187 :119 , 2009
PubMedID: 19429253

Title : Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos - Eddleston_2009_QJM_102_785
Author(s) : Eddleston M , Worek F , Eyer P , Thiermann H , von Meyer L , Jeganathan K , Sheriff MH , Dawson AH , Buckley NA
Ref : Qjm , 102 :785 , 2009
PubMedID: 19737786

Title : Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity - Herkert_2009_Toxicology_258_79
Author(s) : Herkert NM , Lallement G , Clarencon D , Thiermann H , Worek F
Ref : Toxicology , 258 :79 , 2009
PubMedID: 19428926

Title : Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis - Aurbek_2009_Toxicology_259_133
Author(s) : Aurbek N , Thiermann H , Eyer F , Eyer P , Worek F
Ref : Toxicology , 259 :133 , 2009
PubMedID: 19428953

Title : Comments on Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI 6 -
Author(s) : Theirmann H , Worek F , Eyer P
Ref : Toxicol Mech Methods , 19 :334\; author reply 335 , 2009
PubMedID: 19778225

Title : Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness - Eyer_2009_Clin.Toxicol.(Phila)_47_798
Author(s) : Eyer F , Worek F , Eyer P , Felgenhauer N , Haberkorn M , Zilker T , Thiermann H
Ref : Clinical Toxicology (Phila) , 47 :798 , 2009
PubMedID: 19778163

Title : Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF) - Eyer_2009_Biochem.Pharmacol_78_531
Author(s) : Eyer F , Roberts DM , Buckley NA , Eddleston M , Thiermann H , Worek F , Eyer P
Ref : Biochemical Pharmacology , 78 :531 , 2009
PubMedID: 19433070

Title : Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial - Eddleston_2009_PLoS.Med_6_e1000104
Author(s) : Eddleston M , Eyer P , Worek F , Juszczak E , Alder N , Mohamed F , Senarathna L , Hittarage A , Azher S , Jeganathan K , Jayamanne S , von Meyer L , Dawson AH , Sheriff MH , Buckley NA
Ref : PLoS Med , 6 :e1000104 , 2009
PubMedID: 19564902

Title : Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis - Artursson_2009_Toxicology_265_108
Author(s) : Artursson E , Akfur C , Hornberg A , Worek F , Ekstrom F
Ref : Toxicology , 265 :108 , 2009
PubMedID: 19761810

Title : Obidoxime in acute organophosphate poisoning: 2 - PK\/PD relationships - Thiermann_2009_Clin.Toxicol.(Phila)_47_807
Author(s) : Thiermann H , Worek F , Eyer P , Eyer F , Felgenhauer N , Zilker T
Ref : Clinical Toxicology (Phila) , 47 :807 , 2009
PubMedID: 19778190

Title : Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. - Carletti_2009_Biochem.J_421_97
Author(s) : Carletti E , Aurbek N , Gillon E , Loiodice M , Nicolet Y , Fontecilla-Camps JC , Masson P , Thiermann H , Nachon F , Worek F
Ref : Biochemical Journal , 421 :97 , 2009
PubMedID: 19368529
Gene_locus related to this paper: human-BCHE

Title : Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay - Wille_2009_Toxicology_265_96
Author(s) : Wille T , Tenberken O , Reiter G , Muller S , Le Provost R , Lafont O , Estour F , Thiermann H , Worek F
Ref : Toxicology , 265 :96 , 2009
PubMedID: 19800384

Title : The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca(2+) pump - Tazzeo_2009_Br.J.Pharmacol_158_790
Author(s) : Tazzeo T , Worek F , Janssen L
Ref : British Journal of Pharmacology , 158 :790 , 2009
PubMedID: 19788497

Title : A structure-activity analysis of the variation in oxime efficacy against nerve agents - Maxwell_2008_Toxicol.Appl.Pharmacol_231_157
Author(s) : Maxwell DM , Koplovitz I , Worek F , Sweeney RE
Ref : Toxicol Appl Pharmacol , 231 :157 , 2008
PubMedID: 18508103

Title : Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: pig versus minipig acetylcholinesterase - Worek_2008_Toxicology_244_35
Author(s) : Worek F , Aurbek N , Wetherell J , Pearce P , Mann T , Thiermann H
Ref : Toxicology , 244 :35 , 2008
PubMedID: 18054823

Title : LC-MS-based procedures for monitoring of toxic organophosphorus compounds and verification of pesticide and nerve agent poisoning - John_2008_Anal.Bioanal.Chem_391_97
Author(s) : John H , Worek F , Thiermann H
Ref : Anal Bioanal Chem , 391 :97 , 2008
PubMedID: 18330546

Title : Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase - Blum_2008_Biochemistry_47_5216
Author(s) : Blum MM , Timperley CM , Williams GR , Thiermann H , Worek F
Ref : Biochemistry , 47 :5216 , 2008
PubMedID: 18396898

Title : Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity - Eckert_2008_Biochem.Pharmacol_75_698
Author(s) : Eckert S , Eyer P , Herkert N , Bumm R , Weber G , Thiermann H , Worek F
Ref : Biochemical Pharmacology , 75 :698 , 2008
PubMedID: 17977518

Title : Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods - Eckert_2008_Biochem.Pharmacol_75_1561
Author(s) : Eckert S , Eyer P , Melzer M , Thiermann H , Worek F
Ref : Biochemical Pharmacology , 75 :1561 , 2008
PubMedID: 18281016

Title : Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning - Eddleston_2008_QJM_101_467
Author(s) : Eddleston M , Eyer P , Worek F , Sheriff MH , Buckley NA
Ref : Qjm , 101 :467 , 2008
PubMedID: 18375477

Title : Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples - Reiter_2008_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_873_86
Author(s) : Reiter G , Mikler J , Hill I , Weatherby K , Thiermann H , Worek F
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 873 :86 , 2008
PubMedID: 18718824

Title : Are we using the right dose? - a tale of mole and gram -
Author(s) : Eyer P , Eddleston M , Thiermann H , Worek F , Buckley NA
Ref : British Journal of Clinical Pharmacology , 66 :451 , 2008
PubMedID: 18662291

Title : Reactions of isodimethoate with human red cell acetylcholinesterase - Eyer_2008_Biochem.Pharmacol_75_2045
Author(s) : Eyer P , Radtke M , Worek F
Ref : Biochemical Pharmacology , 75 :2045 , 2008
PubMedID: 18384757

Title : Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors - Herkert_2008_Toxicology_246_188
Author(s) : Herkert NM , Eckert S , Eyer P , Bumm R , Weber G , Thiermann H , Worek F
Ref : Toxicology , 246 :188 , 2008
PubMedID: 18304715

Title : Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds - Thiermann_2007_Arh.Hig.Rada.Toksikol_58_359
Author(s) : Thiermann H , Kehe K , Steinritz D , Mikler J , Hill I , Zilker T , Eyer P , Worek F
Ref : Arh Hig Rada Toksikol , 58 :359 , 2007
PubMedID: 17913691

Title : Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning - Thiermann_2007_Toxicology_233_145
Author(s) : Thiermann H , Szinicz L , Eyer P , Felgenhauer N , Zilker T , Worek F
Ref : Toxicology , 233 :145 , 2007
PubMedID: 17161895

Title : Apoptosis in sulfur mustard treated A549 cell cultures - Steinritz_2007_Life.Sci_80_2199
Author(s) : Steinritz D , Emmler J , Hintz M , Worek F , Kreppel H , Szinicz L , Kehe K
Ref : Life Sciences , 80 :2199 , 2007
PubMedID: 17229443

Title : Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis - Worek_2007_Toxicol.Appl.Pharmacol_219_226
Author(s) : Worek F , Eyer P , Aurbek N , Szinicz L , Thiermann H
Ref : Toxicol Appl Pharmacol , 219 :226 , 2007
PubMedID: 17112559

Title : Simulation of cholinesterase status at different scenarios of nerve agent exposure - Worek_2007_Toxicology_233_155
Author(s) : Worek F , Eyer P , Szinicz L , Thiermann H
Ref : Toxicology , 233 :155 , 2007
PubMedID: 16904807

Title : Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase - Bartling_2007_Toxicology_233_166
Author(s) : Bartling A , Worek F , Szinicz L , Thiermann H
Ref : Toxicology , 233 :166 , 2007
PubMedID: 16904809

Title : Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge - Eckert_2007_Toxicology_233_180
Author(s) : Eckert S , Eyer P , Worek F
Ref : Toxicology , 233 :180 , 2007
PubMedID: 17097792

Title : Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates - Worek_2007_Biochem.Pharmacol_73_1807
Author(s) : Worek F , Aurbek N , Koller M , Becker C , Eyer P , Thiermann H
Ref : Biochemical Pharmacology , 73 :1807 , 2007
PubMedID: 17382909

Title : Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro - Becker_2007_Arch.Toxicol_81_415
Author(s) : Becker G , Kawan A , Gutzeit D , Worek F , Szinicz L
Ref : Archives of Toxicology , 81 :415 , 2007
PubMedID: 17151865

Title : Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality - Eyer_2007_Toxicology_233_108
Author(s) : Eyer P , Szinicz L , Thiermann H , Worek F , Zilker T
Ref : Toxicology , 233 :108 , 2007
PubMedID: 17010492

Title : Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q) - Stenzel_2007_Biochem.Pharmacol_74_1390
Author(s) : Stenzel J , Worek F , Eyer P
Ref : Biochemical Pharmacology , 74 :1390 , 2007
PubMedID: 17714697

Title : Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro - Worek_2007_J.Appl.Toxicol_27_582
Author(s) : Worek F , Aurbek N , Thiermann H
Ref : J Appl Toxicol , 27 :582 , 2007
PubMedID: 17370251

Title : Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro - Seeger_2007_Toxicology_233_209
Author(s) : Seeger T , Worek F , Szinicz L , Thiermann H
Ref : Toxicology , 233 :209 , 2007
PubMedID: 17250944

Title : Development of antidotes: problems and strategies - Szinicz_2007_Toxicology_233_23
Author(s) : Szinicz L , Worek F , Thiermann H , Kehe K , Eckert S , Eyer P
Ref : Toxicology , 233 :23 , 2007
PubMedID: 16949190

Title : Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase - Aurbek_2006_Toxicology_224_91
Author(s) : Aurbek N , Thiermann H , Szinicz L , Eyer P , Worek F
Ref : Toxicology , 224 :91 , 2006
PubMedID: 16720069

Title : Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning - Aurbek_2006_Toxicology_224_74
Author(s) : Aurbek N , Thiermann H , Szinicz L , Eyer P , Worek F
Ref : Toxicology , 224 :74 , 2006
PubMedID: 16740352

Title : Development of a dynamic model for real-time determination of membrane-bound acetylcholinesterase activity upon perfusion with inhibitors and reactivators - Eckert_2006_Biochem.Pharmacol_72_358
Author(s) : Eckert S , Eyer P , Muckter H , Worek F
Ref : Biochemical Pharmacology , 72 :358 , 2006
PubMedID: 16725113

Title : Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds - Eckert_2006_Biochem.Pharmacol_72_344
Author(s) : Eckert S , Eyer P , Muckter H , Worek F
Ref : Biochemical Pharmacology , 72 :344 , 2006
PubMedID: 16780806

Title : Respiratory failure in acute organophosphorus pesticide self-poisoning - Eddleston_2006_Qjm_99_513
Author(s) : Eddleston M , Mohamed F , Davies JO , Eyer P , Worek F , Sheriff MH , Buckley NA
Ref : Qjm , 99 :513 , 2006
PubMedID: 16861715

Title : The liberation of thiocholine from acetylthiocholine (ASCh) by pralidoxime iodide (2=PAM) and other oximes (obidoxime and diacetylmonoxime) -
Author(s) : Worek F , Eyer P
Ref : Toxicol Lett , 167 :256 , 2006
PubMedID: 17113251

Title : Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon - Thiermann_2005_Toxicology_214_190
Author(s) : Thiermann H , Eyer P , Worek F , Szinicz L
Ref : Toxicology , 214 :190 , 2005
PubMedID: 16040183

Title : Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning - Thiermann_2005_Chem.Biol.Interact_157-158_345
Author(s) : Thiermann H , Szinicz L , Eyer P , Zilker T , Worek F
Ref : Chemico-Biological Interactions , 157-158 :345 , 2005
PubMedID: 16263103

Title : Diagnostic aspects of organophosphate poisoning - Worek_2005_Toxicology_214_182
Author(s) : Worek F , Koller M , Thiermann H , Szinicz L
Ref : Toxicology , 214 :182 , 2005
PubMedID: 16051411

Title : Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model - Worek_2005_Toxicol.Appl.Pharmacol_209_193
Author(s) : Worek F , Szinicz L , Eyer P , Thiermann H
Ref : Toxicol Appl Pharmacol , 209 :193 , 2005
PubMedID: 15904945

Title : Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study - Eddleston_2005_Lancet_366_1452
Author(s) : Eddleston M , Eyer P , Worek F , Mohamed F , Senarathna L , von Meyer L , Juszczak E , Hittarage A , Azhar S , Dissanayake W , Sheriff MH , Szinicz L , Dawson AH , Buckley NA
Ref : Lancet , 366 :1452 , 2005
PubMedID: 16243090

Title : Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach - Worek_2005_Chem.Biol.Interact_157-158_349
Author(s) : Worek F , Szinicz L , Thiermann H
Ref : Chemico-Biological Interactions , 157-158 :349 , 2005
PubMedID: 16266695

Title : Effect of metoclopramide and ranitidine on the inhibition of human AChE by VX in vitro - Bartling_2005_J.Appl.Toxicol_25_568
Author(s) : Bartling A , Thiermann H , Szinicz L , Worek F
Ref : J Appl Toxicol , 25 :568 , 2005
PubMedID: 16167316

Title : Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1) - Kiderlen_2005_Biochem.Pharmacol_69_1853
Author(s) : Kiderlen D , Eyer P , Worek F
Ref : Biochemical Pharmacology , 69 :1853 , 2005
PubMedID: 15876422

Title : Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines - Worek_2004_Arch.Toxicol_78_212
Author(s) : Worek F , Thiermann H , Szinicz L
Ref : Archives of Toxicology , 78 :212 , 2004
PubMedID: 14647978

Title : Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes - Worek_2004_Biochem.Pharmacol_68_2237
Author(s) : Worek F , Thiermann H , Szinicz L , Eyer P
Ref : Biochemical Pharmacology , 68 :2237 , 2004
PubMedID: 15498514

Title : Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase - Herkenhoff_2004_Arch.Toxicol_78_338
Author(s) : Herkenhoff S , Szinicz L , Rastogi VK , Cheng TC , DeFrank JJ , Worek F
Ref : Archives of Toxicology , 78 :338 , 2004
PubMedID: 14985944

Title : Molar absorption coefficients for the reduced Ellman reagent: reassessment - Eyer_2003_Anal.Biochem_312_224
Author(s) : Eyer P , Worek F , Kiderlen D , Sinko G , Stuglin A , Simeon-Rudolf V , Reiner E
Ref : Analytical Biochemistry , 312 :224 , 2003
PubMedID: 12531209

Title : Human parathion poisoning. A toxicokinetic analysis - Eyer_2003_Toxicol.Rev_22_143
Author(s) : Eyer F , Meischner V , Kiderlen D , Thiermann H , Worek F , Haberkorn M , Felgenhauer N , Zilker T , Eyer P
Ref : Toxicol Rev , 22 :143 , 2003
PubMedID: 15181664

Title : Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates - Worek_2002_Arch.Toxicol_76_523
Author(s) : Worek F , Reiter G , Eyer P , Szinicz L
Ref : Archives of Toxicology , 76 :523 , 2002
PubMedID: 12242610

Title : Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonate - Krummer_2002_Arch.Toxicol_76_589
Author(s) : Krummer S , Thiermann H , Worek F , Eyer P
Ref : Archives of Toxicology , 76 :589 , 2002
PubMedID: 12373455

Title : Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss - Felgenhauer_2000_J.Toxicol.Clin.Toxicol_38_803
Author(s) : Felgenhauer N , Zilker T , Worek F , Eyer P
Ref : J Toxicol Clinical Toxicology , 38 :803 , 2000
PubMedID: 11192470

Title : Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase - Worek_2000_Arch.Toxicol_74_21
Author(s) : Worek F , Eyer P , Kiderlen D , Thiermann H , Szinicz L
Ref : Archives of Toxicology , 74 :21 , 2000
PubMedID: 10817663

Title : The phosphoryl oxime-destroying activity of human plasma - Kiderlen_2000_Arch.Toxicol_74_27
Author(s) : Kiderlen D , Worek F , Klimmek R , Eyer P
Ref : Archives of Toxicology , 74 :27 , 2000
PubMedID: 10817664

Title : Modern strategies in therapy of organophosphate poisoning - Thiermann_1999_Toxicol.Lett_107_233
Author(s) : Thiermann H , Szinicz L , Eyer F , Worek F , Eyer P , Felgenhauer N , Zilker T
Ref : Toxicol Lett , 107 :233 , 1999
PubMedID: 10414801

Title : Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics - Worek_1999_Arch.Toxicol_73_7
Author(s) : Worek F , Diepold C , Eyer P
Ref : Archives of Toxicology , 73 :7 , 1999
PubMedID: 10207609

Title : Improved determination of acetylcholinesterase activity in human whole blood - Worek_1999_Clin.Chim.Acta_288_73
Author(s) : Worek F , Mast U , Kiderlen D , Diepold C , Eyer P
Ref : Clinica Chimica Acta , 288 :73 , 1999
PubMedID: 10529460

Title : Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds - Worek_1998_Arch.Toxicol_72_237
Author(s) : Worek F , Widmann R , Knopff O , Szinicz L
Ref : Archives of Toxicology , 72 :237 , 1998
PubMedID: 9587020

Title : Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases - Worek_1998_Arch.Toxicol_72_580
Author(s) : Worek F , Eyer P , Szinicz L
Ref : Archives of Toxicology , 72 :580 , 1998
PubMedID: 9806430

Title : Acetylcholinesterase, a Versatile Protein -
Author(s) : Szinicz L , Thiermann H , Worek F , Eyer P
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :269 , 1998
PubMedID:

Title : Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning [editorial] -
Author(s) : Zilker T , Felgenhauer N , Hibler A , Pfab R , Thiermann H , Worek F , Eyer P
Ref : Przegl Lek , 54 :662 , 1997
PubMedID: 9478082

Title : Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning - Worek_1997_Hum.Exp.Toxicol_16_466
Author(s) : Worek F , Backer M , Thiermann H , Szinicz L , Mast U , Klimmek R , Eyer P
Ref : Hum Exp Toxicol , 16 :466 , 1997
PubMedID: 9292287

Title : Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds - Worek_1996_Arch.Toxicol_70_497
Author(s) : Worek F , Kirchner T , Backer M , Szinicz L
Ref : Archives of Toxicology , 70 :497 , 1996
PubMedID: 8783813

Title : Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea-pigs: effect of pyridostigmine pretreatment - Worek_1995_Arch.Toxicol_69_322
Author(s) : Worek F , Szinicz L
Ref : Archives of Toxicology , 69 :322 , 1995
PubMedID: 7654137

Title : Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning - Worek_1995_Human.Exp.Toxicol_14_634
Author(s) : Worek F , Kleine A , Szinicz L
Ref : Hum Exp Toxicol , 14 :634 , 1995
PubMedID: 7576830

Title : Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin - Worek_1995_Toxicology_95_123
Author(s) : Worek F , Kirchner T , Szinicz L
Ref : Toxicology , 95 :123 , 1995
PubMedID: 7825179

Title : Effects of atropine and soman on the pharmacokinetics of the oxime HLo 7 dimethanesulfonate in anesthetized guinea-pigs - Worek_1995_Drug.Chem.Toxicol_18_137
Author(s) : Worek F , Klimmek R , Szinicz L
Ref : Drug & Chemical Toxicology , 18 :137 , 1995
PubMedID: 7497908

Title : Arrhythmias in organophosphate poisoning: effect of atropine and bispyridinium oximes - Worek_1995_Arch.Int.Pharmacodyn.Ther_329_418
Author(s) : Worek F , Kleine A , Falke K , Szinicz L
Ref : Archives Internationales de Pharmacodynamie et de Therapie , 329 :418 , 1995
PubMedID: 8546540

Title : Treatment of tabun poisoned guinea-pigs with atropine, HLo 7 or HI 6: effect on respiratory and circulatory function - Worek_1994_Arch.Toxicol_68_231
Author(s) : Worek F , Kirchner T , Szinicz L
Ref : Archives of Toxicology , 68 :231 , 1994
PubMedID: 8067895

Title : Effect of atropine, HLo 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX) - Worek_1994_Pharmacol.Toxicol_75_302
Author(s) : Worek F , Kirchner T , Szinicz L
Ref : Pharmacol Toxicol , 75 :302 , 1994
PubMedID: 7870702

Title : Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLo 7 dimethanesulfonate versus HI 6 dichloride - Worek_1993_Pharmacol.Toxicol_72_13
Author(s) : Worek F , Szinicz L
Ref : Pharmacol Toxicol , 72 :13 , 1993
PubMedID: 8441735

Title : Investigation of acute cardiovascular and respiratory toxicity of HLo 7 dimethanesulfonate and HI 6 dichloride in anaesthetized guinea-pigs - Worek_1993_Pharmacol.Toxicol_73_91
Author(s) : Worek F , Szinicz L
Ref : Pharmacol Toxicol , 73 :91 , 1993
PubMedID: 8248012

Title : HLo 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases - Eyer_1992_Arch.Toxicol_66_603
Author(s) : Eyer P , Hagedorn I , Klimmek R , Lippstreu P , Loffler M , Oldiges H , Spohrer U , Steidl I , Szinicz L , Worek F
Ref : Archives of Toxicology , 66 :603 , 1992
PubMedID: 1482283