W251L_luccu-E3aest7

General

Gene Locus : luccu-E3aest7

Mode of mutation : Natural mutant || Site directed mutagenesis

Disease :

Summary : OP-resistance mutant bowfly are resistant to OP insecticides, increases OP hydrolase activity (E3-Rmal Malathion and dimethyl OP) and alters kinetics for several carboxylester substrates Devonshire_2003_Pestic.Biochem.Physiol_76_1 || OP-resistance 2 G137D and 2 W251L haplotypes found in natural populations Newcomb_2005_J.Mol.Evol_60_207 || OP-resistance search for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353 || Pyrethroids hydrolysis search for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597 || Pyrethroids hydrolysis Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases Devonshire_2007_Insect.Biochem.Mol.Biol_37_891 || OP-resistance search for OP hydrolase and MCE activities Campbell_1998_Insect.Biochem.Mol.Biol_28_139

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance || Pyrethroids hydrolysis

Torpedo_number : 233

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.Trp251Leu . In Cui et al. called W271L in some insects in some insects enzymes tested by site directed mutagenesis: two lepidopteran species (Spodoptera litura, B. mori), two homopteran species (Aphis gossypii, Nilaparvata lugens), two coleopteran species (T. castaneum, Harmonia axyridis) and one hymenopteran species (A. mellifera)

References (8)

Title : Two single mutations commonly cause qualitative change of nonspecific carboxylesterases in insects - Cui_2011_Insect.Biochem.Mol.Biol_41_1
Author(s) : Cui F , Lin Z , Wang H , Liu S , Chang H , Reeck G , Qiao C , Raymond M , Kang L
Ref : Insect Biochemistry & Molecular Biology , 41 :1 , 2011
PubMedID: 20888910
Gene_locus related to this paper: aphgo-cxest

Title : Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases from Lucilia cuprina - Devonshire_2007_Insect.Biochem.Mol.Biol_37_891
Author(s) : Devonshire AL , Heidari R , Huang HZ , Hammock BD , Russell RJ , Oakeshott JG
Ref : Insect Biochemistry & Molecular Biology , 37 :891 , 2007
PubMedID: 17681228
Gene_locus related to this paper: luccu-E3aest7

Title : Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolution of insecticide resistance - Hartley_2006_Proc.Natl.Acad.Sci.U.S.A_103_8757
Author(s) : Hartley CJ , Newcomb RD , Russell RJ , Yong CG , Stevens JR , Yeates DK , La Salle J , Oakeshott JG
Ref : Proc Natl Acad Sci U S A , 103 :8757 , 2006
PubMedID: 16723400

Title : Hydrolysis of pyrethroids by carboxylesterases from Lucilia cuprina and Drosophila melanogaster with active sites modified by in vitro mutagenesis - Heidari_2005_Insect.Biochem.Mol.Biol_35_597
Author(s) : Heidari R , Devonshire AL , Campbell BE , Dorrian SJ , Oakeshott JG , Russell RJ
Ref : Insect Biochemistry & Molecular Biology , 35 :597 , 2005
PubMedID: 15857765
Gene_locus related to this paper: drome-EST23aes07 , luccu-E3aest7

Title : Multiple mutations and gene duplications conferring organophosphorus insecticide resistance have been selected at the Rop-1 locus of the sheep blowfly, Lucilia cuprina - Newcomb_2005_J.Mol.Evol_60_207
Author(s) : Newcomb RD , Gleeson DM , Yong CG , Russell RJ , Oakeshott JG
Ref : Journal of Molecular Evolution , 60 :207 , 2005
PubMedID: 15785849
Gene_locus related to this paper: luccu-E3aest7

Title : Hydrolysis of organophosphorus insecticides by in vitro modified carboxylesterase E3 from Lucilia cuprina - Heidari_2004_Insect.Biochem.Mol.Biol_34_353
Author(s) : Heidari R , Devonshire AL , Campbell BE , Bell KL , Dorrian SJ , Oakeshott JG , Russell RJ
Ref : Insect Biochemistry & Molecular Biology , 34 :353 , 2004
PubMedID: 15041019
Gene_locus related to this paper: luccu-E3aest7

Title : Kinetic efficiency of mutant carboxylesterases implicated in organophosphate insecticide resistance - Devonshire_2003_Pestic.Biochem.Physiol_76_1
Author(s) : Devonshire AL , Heidari R , Bell KL , Campbell PM , Campbell BE , Odgers WA , Oakeshott JG , Russell RJ
Ref : Pesticide Biochemistry and Physiology , 76 :1 , 2003
PubMedID:
Gene_locus related to this paper: luccu-E3aest7 , musdo-EST23aes07

Title : Two different amino acid substitutions in the ali-esterase, E3, confer alternative types of organophosphorus insecticide resistance in the sheep blowfly, Lucilia cuprina - Campbell_1998_Insect.Biochem.Mol.Biol_28_139
Author(s) : Campbell PM , Newcomb RD , Russell RJ , Oakeshott JG
Ref : Insect Biochemistry & Molecular Biology , 28 :139 , 1998
PubMedID:
Gene_locus related to this paper: luccu-E3aest7