Fukuda_2011_Nature_469_543

Reference

Title : Bifidobacteria can protect from enteropathogenic infection through production of acetate - Fukuda_2011_Nature_469_543
Author(s) : Fukuda S , Toh H , Hase K , Oshima K , Nakanishi Y , Yoshimura K , Tobe T , Clarke JM , Topping DL , Suzuki T , Taylor TD , Itoh K , Kikuchi J , Morita H , Hattori M , Ohno H
Ref : Nature , 469 :543 , 2011
Abstract :

The human gut is colonized with a wide variety of microorganisms, including species, such as those belonging to the bacterial genus Bifidobacterium, that have beneficial effects on human physiology and pathology. Among the most distinctive benefits of bifidobacteria are modulation of host defence responses and protection against infectious diseases. Nevertheless, the molecular mechanisms underlying these effects have barely been elucidated. To investigate these mechanisms, we used mice associated with certain bifidobacterial strains and a simplified model of lethal infection with enterohaemorrhagic Escherichia coli O157:H7, together with an integrated 'omics' approach. Here we show that genes encoding an ATP-binding-cassette-type carbohydrate transporter present in certain bifidobacteria contribute to protecting mice against death induced by E. coli O157:H7. We found that this effect can be attributed, at least in part, to increased production of acetate and that translocation of the E. coli O157:H7 Shiga toxin from the gut lumen to the blood was inhibited. We propose that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.

PubMedSearch : Fukuda_2011_Nature_469_543
PubMedID: 21270894
Gene_locus related to this paper: bifli-c2gxu7 , biflo-BL0073 , biflo-BL0336 , biflo-BL0581 , biflo-BL0582 , biflo-BL0682 , biflo-BL0787 , biflo-BL0807 , biflo-BL1109 , biflo-BL1514 , biflo-PAP , biflo-PTRB , bifln-c2gtr2

Related information

Gene_locus bifli-c2gxu7    biflo-BL0073    biflo-BL0336    biflo-BL0581    biflo-BL0582    biflo-BL0682    biflo-BL0787    biflo-BL0807    biflo-BL1109    biflo-BL1514    biflo-PAP    biflo-PTRB    bifln-c2gtr2

Citations formats

Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H (2011)
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Nature 469 :543

Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H (2011)
Nature 469 :543