Title : Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration - Karasova_2013_Neuro.Endocrinol.Lett_34_74 |
Author(s) : Karasova JZ , Zemek F , Kunes M , Kvetina J , Chladek J , Jun D , Bures J , Tacheci I , Kuca K |
Ref : Neuro Endocrinol Lett , 34 :74 , 2013 |
Abstract :
OBJECTIVES: Oxime HI-6 is an acetylcholinesterase reactivator therapeutically efficient against nerve agents. Because of their physico-chemical properties, oximes are typically applied intramuscularly (i.m.). This route of administration has also some disadvantages, and alternative strategies ought to be examined. We evaluated the pharmacokinetic profiles of two HI-6 salts after their intravenous (i.v.) administration, and compare the results with the known pharmacokinetics after i.m. administration. |
PubMedSearch : Karasova_2013_Neuro.Endocrinol.Lett_34_74 |
PubMedID: 24362096 |
Karasova JZ, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tacheci I, Kuca K (2013)
Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration
Neuro Endocrinol Lett
34 :74
Karasova JZ, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tacheci I, Kuca K (2013)
Neuro Endocrinol Lett
34 :74