| Title : Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents - Kim_2005_Bioorg.Med.Chem.Lett_15_2914 |
| Author(s) : Kim TH , Kuca K , Jun D , Jung YS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2914 , 2005 |
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Abstract :
New bis-pyridinium oxime reactivators connected with a CH(2)CH(2)OCH(2)CH(2) linker between two pyridinium rings were designed and synthesized. In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10% at the lower concentration 10(-4)M. |
| PubMedSearch : Kim_2005_Bioorg.Med.Chem.Lett_15_2914 |
| PubMedID: 15911280 |
Kim TH, Kuca K, Jun D, Jung YS (2005)
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents
Bioorganic & Medicinal Chemistry Lett
15 :2914
Kim TH, Kuca K, Jun D, Jung YS (2005)
Bioorganic & Medicinal Chemistry Lett
15 :2914