K117
General
Type : Oxime, Bispyridinium, Bisoxime
Chemical_Nomenclature : (NZ)-N-[[1-[2-[2-[4-[(Z)-hydroxyiminomethyl]pyridin-1-ium-1-yl]ethoxy]ethyl]pyridin-1-ium-4-yl]methylidene]hydroxylamine
Canonical SMILES : C1=C[N+](=CC=C1C=NO)CCOCC[N+]2=CC=C(C=C2)C=NO
InChI : InChI=1S\/C16H18N4O3\/c21-17-13-15-1-5-19(6-2-15)9-11-23-12-10-20-7-3-16(4-8-20)14-18-22\/h1-8,13-14H,9-12H2\/p+2
InChIKey : OQKZASQGSACWEZ-UHFFFAOYSA-P
Other name(s) : 1,5-bis(4-hydroxymethylpyridinium)-3-oxapentane dibromide
MW : 316.36
Formula : C16H20N4O3+2
CAS_number :
PubChem : 135723044, 135524929
UniChem : OQKZASQGSACWEZ-UHFFFAOYSA-P
Target
Structure : No structure
Families : No family
References (6)
| Title : Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning - Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737 |
| Author(s) : Tekes K , Karvaly G , Nurulain SM , Kuca K , Musilek K , Adeghate E , Jung YS , Kalasz H |
| Ref : Chemico-Biological Interactions , 310 :108737 , 2019 |
| Abstract : |
| PubMedSearch : Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737 |
| PubMedID: 31279792 |
| Title : Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon - Kuca_2018_Molecules_23_ |
| Author(s) : Kuca K , Jun D , Junova L , Musilek K , Hrabinova M , da Silva JAV , Ramalho TC , Valko M , Wu Q , Nepovimova E , Franca TCC |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Kuca_2018_Molecules_23_ |
| PubMedID: 29735900 |
| Title : A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats - Kassa_2009_Toxicol.Mech.Methods_19_232 |
| Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K , Jung AY |
| Ref : Toxicol Mech Methods , 19 :232 , 2009 |
| Abstract : |
| PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_232 |
| PubMedID: 19730756 |
| Title : Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127 - Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| Author(s) : Kuca K , Cabal J , Jung YS , Musilek K , Soukup O , Jun D , Pohanka M , Musilova L , Karasova J , Novotny L , Hrabinova M |
| Ref : Basic Clin Pharmacol Toxicol , 105 :207 , 2009 |
| Abstract : |
| PubMedSearch : Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| PubMedID: 19473310 |
| Title : A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Drug.Chem.Toxicol_31_371 |
| Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Jung YS |
| Ref : Drug & Chemical Toxicology , 31 :371 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_Drug.Chem.Toxicol_31_371 |
| PubMedID: 18622871 |
| Title : Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents - Kim_2005_Bioorg.Med.Chem.Lett_15_2914 |
| Author(s) : Kim TH , Kuca K , Jun D , Jung YS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2914 , 2005 |
| Abstract : |
| PubMedSearch : Kim_2005_Bioorg.Med.Chem.Lett_15_2914 |
| PubMedID: 15911280 |