K127
General
Type : Oxime, Bispyridinium
Chemical_Nomenclature :
Canonical SMILES : C1(=CC=[N+](C=C1)CCOCC[N+]2=CC=C(C=C2)C(=O)N([H])[H])C(=NO[H])[H]
InChI : InChI=1S\/C16H18N4O3\/c17-16(21)15-3-7-20(8-4-15)10-12-23-11-9-19-5-1-14(2-6-19)13-18-22\/h1-8,13H,9-12H2,(H-,17,21)\/p+2
InChIKey : OVVOCKYUHCQSBH-UHFFFAOYSA-P
Other name(s) : 1-(4-carbamoylpyridinium)-5-(4-hydroxyimino-methylpyridinium)-3-oxapentane dibromide
Target
Structure : No structure
Families : No family
References (5)
| Title : Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning - Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737 |
| Author(s) : Tekes K , Karvaly G , Nurulain SM , Kuca K , Musilek K , Adeghate E , Jung YS , Kalasz H |
| Ref : Chemico-Biological Interactions , 310 :108737 , 2019 |
| Abstract : |
| PubMedSearch : Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737 |
| PubMedID: 31279792 |
| Title : A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats - Kassa_2009_Toxicol.Mech.Methods_19_232 |
| Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K , Jung AY |
| Ref : Toxicol Mech Methods , 19 :232 , 2009 |
| Abstract : |
| PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_232 |
| PubMedID: 19730756 |
| Title : Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127 - Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| Author(s) : Kuca K , Cabal J , Jung YS , Musilek K , Soukup O , Jun D , Pohanka M , Musilova L , Karasova J , Novotny L , Hrabinova M |
| Ref : Basic Clin Pharmacol Toxicol , 105 :207 , 2009 |
| Abstract : |
| PubMedSearch : Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| PubMedID: 19473310 |
| Title : A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Drug.Chem.Toxicol_31_371 |
| Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Jung YS |
| Ref : Drug & Chemical Toxicology , 31 :371 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_Drug.Chem.Toxicol_31_371 |
| PubMedID: 18622871 |
| Title : Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents - Kim_2005_Bioorg.Med.Chem.Lett_15_2914 |
| Author(s) : Kim TH , Kuca K , Jun D , Jung YS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2914 , 2005 |
| Abstract : |
| PubMedSearch : Kim_2005_Bioorg.Med.Chem.Lett_15_2914 |
| PubMedID: 15911280 |