Lehmann_2016_Medchemcomm_7_1797

Reference

Title : Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases - Lehmann_2016_Medchemcomm_7_1797
Author(s) : Lehmann J , Vomacka J , Esser K , Nodwell M , Kolbe K , Ramer P , Protzer U , Reiling N , Sieber SA
Ref : Medchemcomm , 7 :1797 , 2016
Abstract :

Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.

PubMedSearch : Lehmann_2016_Medchemcomm_7_1797
PubMedID:
Gene_locus related to this paper: myctu-cutas1 , myctu-lipG , myctu-RV0045C , myctu-rv0183 , myctu-RV0293C , myctu-RV0840C , myctu-Rv1191 , myctu-RV1192 , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-Rv2045c , myctu-Rv2284 , myctu-Rv2970c , myctu-Rv3084 , myctu-YR15 , larcr-a0a0f7ir14

Related information

Citations formats

Lehmann J, Vomacka J, Esser K, Nodwell M, Kolbe K, Ramer P, Protzer U, Reiling N, Sieber SA (2016)
Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases
Medchemcomm 7 :1797

Lehmann J, Vomacka J, Esser K, Nodwell M, Kolbe K, Ramer P, Protzer U, Reiling N, Sieber SA (2016)
Medchemcomm 7 :1797