myctu-rv0183
Mycobacterium tuberculosis, Mycobacterium bovis gene lipG Rv0183/mtbMGL
Comment
Inhibiting Monoacylglycerol lipases (MGLs) degrading lipases might have toxic effects onto M. tuberculosis. It is a potential drug target that remains accessible during the dormant phase of Mtb infection (see Aschauer et al.<\/A>). JZL184 a human monoacylglycerol lipase selective inhibitor, does not inhibits Rv0183. 
There are more than 3000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains
Relationship
Family : Monoglyceridelipase_lysophospholip
Block : X
Position in NCBI Life Tree : Mycobacterium tuberculosis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Corynebacteriales N E > Mycobacteriaceae N E > Mycobacterium N E > Mycobacterium tuberculosis complex N E > Mycobacterium tuberculosis N EMolecular evidence
Database
Sequence
Peptide
MWAEKSPRRS SAGSRPEFSA STLTSMSLRR VSDTLTGAAV TLPVMTTTRT ERNFAGIGDV RIVYDVWTPD TAPQAVVVLA HGLGEHARRY DHVAQRLGAA GLVTYALDHR GHGRSGGKRV LVRDISEYTA DFDTLVGIAT REYPGCKRIV LGHSMGGGIV FAYGVERPDN YDLMVLSAPA VAAQDLVSPV VAVAAKLLGV VVPGLPVQEL DFTAISRDPE VVQAYNTDPL VHHGRVPAGI GRALLQVGET MPRRAPALTA PLLVLHGTDD RLIPIEGSRR LVECVGSADV QLKEYPGLYH EVFNEPERNQ VLDDVVAWLT ERL
References (15)
| Title : Structural Changes in the Cap of Rv0183\/mtbMGL Modulate the Shape of the Binding Pocket - Grininger_2021_Biomolecules_11_1299 |
| Author(s) : Grininger C , Leypold M , Aschauer P , Pavkov-Keller T , Riegler-Berket L , Breinbauer R , Oberer M |
| Ref : Biomolecules , 11 :1299 , 2021 |
| PubMedID: 34572512 |
| Gene_locus related to this paper: myctu-rv0183 |
| Title : Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183 - Abrahams_2020_Cell.Surf_6_100040 |
| Author(s) : Abrahams KA , Hu W , Li G , Lu Y , Richardson EJ , Loman NJ , Huang H , Besra GS |
| Ref : Cell Surf , 6 :100040 , 2020 |
| PubMedID: 32743152 |
| Gene_locus related to this paper: myctu-rv0183 |
| Title : The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition - Aschauer_2018_Sci.Rep_8_8948 |
| Author(s) : Aschauer P , Zimmermann R , Breinbauer R , Pavkov-Keller T , Oberer M |
| Ref : Sci Rep , 8 :8948 , 2018 |
| PubMedID: 29895832 |
| Gene_locus related to this paper: myctu-rv0183 |
| Title : IL-6 release of Rv0183 antigen-stimulated whole blood is a potential biomarker for active tuberculosis patients - Liu_2018_J.Infect_76_376 |
| Author(s) : Liu Y , Li X , Liu W , Zhong Z , Wang L , Ge S , Zhang J , Xia N |
| Ref : J Infect , 76 :376 , 2018 |
| PubMedID: 29174965 |
| Gene_locus related to this paper: myctu-rv0183 |
| Title : Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases - Lehmann_2016_Medchemcomm_7_1797 |
| Author(s) : Lehmann J , Vomacka J , Esser K , Nodwell M , Kolbe K , Ramer P , Protzer U , Reiling N , Sieber SA |
| Ref : Medchemcomm , 7 :1797 , 2016 |
| PubMedID: |
| Gene_locus related to this paper: myctu-cutas1 , myctu-lipG , myctu-RV0045C , myctu-rv0183 , myctu-RV0293C , myctu-RV0840C , myctu-Rv1191 , myctu-RV1192 , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-Rv2045c , myctu-Rv2284 , myctu-Rv2970c , myctu-Rv3084 , myctu-YR15 , larcr-a0a0f7ir14 |
| Title : Small-Molecule Probes Reveal Esterases with Persistent Activity in Dormant and Reactivating Mycobacterium tuberculosis - Tallman_2016_ACS.Infect.Dis_2_936 |
| Author(s) : Tallman KR , Levine SR , Beatty KE |
| Ref : ACS Infect Dis , 2 :936 , 2016 |
| PubMedID: 27690385 |
| Gene_locus related to this paper: myctu-rv0183 , myctu-Rv1399c , myctu-RV1683 , myctu-Rv2284 , myctu-Rv2970c , myctu-ym24 |
| Title : Potential selective inhibitors against Rv0183 of Mycobacterium tuberculosis targeting host lipid metabolism - Saravanan_2012_Chem.Biol.Drug.Des_79_1056 |
| Author(s) : Saravanan P , Dubey VK , Patra S |
| Ref : Chemical Biology Drug Des , 79 :1056 , 2012 |
| PubMedID: 22405030 |
| Gene_locus related to this paper: myctu-rv0183 |
| Title : Hemolytic phospholipase Rv0183 of Mycobacterium tuberculosis induces inflammatory response and apoptosis in alveolar macrophage RAW264.7 cells - Xu_2010_Can.J.Microbiol_56_916 |
| Author(s) : Xu G , Jia H , Li Y , Liu X , Li M , Wang Y |
| Ref : Can J Microbiol , 56 :916 , 2010 |
| PubMedID: 21076482 |
| Gene_locus related to this paper: myctu-rv0183 |
| Title : Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids - Cotes_2007_Biochem.J_408_417 |
| Author(s) : Cotes K , Dhouib R , Douchet I , Chahinian H , de Caro A , Carriere F , Canaan S |
| Ref : Biochemical Journal , 408 :417 , 2007 |
| PubMedID: 17784850 |
| Gene_locus related to this paper: myctu-rv0183 |