Mycobacterium tuberculosis and Mycobacterium bovis. Carboxylesterase lipH Rv1399c NLHH
myctu-Rv1399 is a nonlipolytic hydrolase (Canaan et al. 2004). Hydrolyzes various short-chain esters, such as triacylglycerols and vinyl esters. Has no activity against emulsified substrates.. There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains
Family : Hormone-sensitive_lipase_like
Block : H
Position in NCBI Life Tree : Mycobacterium tuberculosis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Corynebacteriales N E > Mycobacteriaceae N E > Mycobacterium N E > Mycobacterium tuberculosis complex N E > Mycobacterium tuberculosis N EMTEPTVARPD IDPVLKMLLD TFPVTFTAAD GVEVARARLR QLKTPPELLP ELRIEERTVG YDGLTDIPVR VYWPPVVRDN LPVVVYYHGG GWSLGGLDTH DPVARAHAVG AQAIVVSVDY RLAPEHPYPA GIDDSWAALR WVGENAAELG GDPSRIAVAG DSAGGNISAV MAQLARDVGG PPLVFQLLWY PTTMADLSLP SFTENADAPI LDRDVIDAFL AWYVPGLDIS DHTMLPTTLA PGNADLSGLP PAFIGTAEHD PLRDDGACYA ELLTAAGVSV ELSNEPTMVH GYVNFALVVP AAAEATGRGL AALKRALHA
Title : Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis - Nguyen_2017_Sci.Rep_7_11751 |
Author(s) : Nguyen PC , Delorme V , Benarouche A , Martin BP , Paudel R , Gnawali GR , Madani A , Puppo R , Landry V , Kremer L , Brodin P , Spilling CD , Cavalier JF , Canaan S |
Ref : Sci Rep , 7 :11751 , 2017 |
Abstract : |
PubMedSearch : Nguyen_2017_Sci.Rep_7_11751 |
PubMedID: 28924204 |
Gene_locus related to this paper: mycle-ML2603 , myctu-a85a , myctu-a85c , myctu-Rv1399c , myctu-Rv2970c , myctu-Rv3569c , myctu-yt28 |
Title : Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases - Lehmann_2016_Medchemcomm_7_1797 |
Author(s) : Lehmann J , Vomacka J , Esser K , Nodwell M , Kolbe K , Ramer P , Protzer U , Reiling N , Sieber SA |
Ref : Medchemcomm , 7 :1797 , 2016 |
Abstract : |
PubMedSearch : Lehmann_2016_Medchemcomm_7_1797 |
PubMedID: |
Gene_locus related to this paper: myctu-cutas1 , myctu-lipG , myctu-RV0045C , myctu-rv0183 , myctu-RV0293C , myctu-RV0840C , myctu-Rv1191 , myctu-RV1192 , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-Rv2045c , myctu-Rv2284 , myctu-Rv2970c , myctu-Rv3084 , myctu-YR15 , larcr-a0a0f7ir14 |
Title : Small-Molecule Probes Reveal Esterases with Persistent Activity in Dormant and Reactivating Mycobacterium tuberculosis - Tallman_2016_ACS.Infect.Dis_2_936 |
Author(s) : Tallman KR , Levine SR , Beatty KE |
Ref : ACS Infect Dis , 2 :936 , 2016 |
Abstract : |
PubMedSearch : Tallman_2016_ACS.Infect.Dis_2_936 |
PubMedID: 27690385 |
Gene_locus related to this paper: myctu-rv0183 , myctu-Rv1399c , myctu-RV1683 , myctu-Rv2284 , myctu-Rv2970c , myctu-ym24 |
Title : Expression and characterization of the protein Rv1399c from Mycobacterium tuberculosis. A novel carboxyl esterase structurally related to the HSL family - Canaan_2004_Eur.J.Biochem_271_3953 |
Author(s) : Canaan S , Maurin D , Chahinian H , Pouilly B , Durousseau C , Frassinetti F , Scappuccini-Calvo L , Cambillau C , Bourne Y |
Ref : European Journal of Biochemistry , 271 :3953 , 2004 |
Abstract : |
PubMedSearch : Canaan_2004_Eur.J.Biochem_271_3953 |
PubMedID: 15373841 |
Gene_locus related to this paper: myctu-Rv1399c |
Title : An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae - Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
Author(s) : Philipp WJ , Poulet S , Eiglmeier K , Pascopella L , Balasubramanian V , Heym B , Bergh S , Bloom BR , Jacobs WR, Jr. , Cole ST |
Ref : Proc Natl Acad Sci U S A , 93 :3132 , 1996 |
Abstract : |
PubMedSearch : Philipp_1996_Proc.Natl.Acad.Sci.U.S.A_93_3132 |
PubMedID: 8610181 |
Gene_locus related to this paper: myctu-Rv0217c , myctu-Rv0220 , myctu-Rv1076 , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-Rv2045c , myctu-Rv2284 , myctu-Rv2385 , myctu-Rv2485c , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-Rv3487c |