| Title : Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands - Li_2010_Bioorg.Med.Chem.Lett_20_3636 |
| Author(s) : Li T , Bunnelle WH , Ryther KB , Anderson DJ , Malysz J , Helfrich R , Gronlien JH , Hakerud M , Peters D , Schrimpf MR , Gopalakrishnan M , Ji J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :3636 , 2010 |
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Abstract :
Biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes have been synthesized and tested for their affinity toward alpha7 neuronal nicotinic receptors (NNRs). SAR studies established that 5-N-methyl substituent, heteroaryl linker and the nature of terminal aryl group are critical for the ligand to achieve potent alpha7 NNR agonist activity. |
| PubMedSearch : Li_2010_Bioorg.Med.Chem.Lett_20_3636 |
| PubMedID: 20472430 |
Li T, Bunnelle WH, Ryther KB, Anderson DJ, Malysz J, Helfrich R, Gronlien JH, Hakerud M, Peters D, Schrimpf MR, Gopalakrishnan M, Ji J (2010)
Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands
Bioorganic & Medicinal Chemistry Lett
20 :3636
Li T, Bunnelle WH, Ryther KB, Anderson DJ, Malysz J, Helfrich R, Gronlien JH, Hakerud M, Peters D, Schrimpf MR, Gopalakrishnan M, Ji J (2010)
Bioorganic & Medicinal Chemistry Lett
20 :3636