| Title : SAR of alpha7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore - Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633 |
| Author(s) : Schrimpf MR , Sippy KB , Briggs CA , Anderson DJ , Li T , Ji J , Frost JM , Surowy CS , Bunnelle WH , Gopalakrishnan M , Meyer MD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1633 , 2012 |
| Abstract : |
| PubMedSearch : Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633 |
| PubMedID: 22281189 |
| Title : Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent alpha4beta2 nicotinic acetylcholine receptor ligands - Scanio_2011_J.Med.Chem_54_7678 |
| Author(s) : Scanio MJ , Shi L , Bunnelle WH , Anderson DJ , Helfrich RJ , Malysz J , Thorin-Hagene KK , Van Handel CE , Marsh KC , Lee CH , Gopalakrishnan M |
| Ref : Journal of Medicinal Chemistry , 54 :7678 , 2011 |
| Abstract : |
| PubMedSearch : Scanio_2011_J.Med.Chem_54_7678 |
| PubMedID: 21962147 |
| Title : Role of alpha7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-alpha (TNF-alpha) as revealed by subtype selective agonists - Li_2011_J.Neuroimmunol_239_37 |
| Author(s) : Li J , Mathieu SL , Harris R , Ji J , Anderson DJ , Malysz J , Bunnelle WH , Waring JF , Marsh KC , Murtaza A , Olson LM , Gopalakrishnan M |
| Ref : Journal of Neuroimmunology , 239 :37 , 2011 |
| Abstract : |
| PubMedSearch : Li_2011_J.Neuroimmunol_239_37 |
| PubMedID: 21911260 |
| Title : Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor - Mortell_2010_Bioorg.Med.Chem.Lett_20_104 |
| Author(s) : Mortell KH , Schrimpf MR , Bunnelle WH , Anderson DJ , Gronlien JH , Hagene KT , Gopalakrishnan M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :104 , 2010 |
| Abstract : |
| PubMedSearch : Mortell_2010_Bioorg.Med.Chem.Lett_20_104 |
| PubMedID: 19954975 |
| Title : In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107 - Malysz_2010_J.Pharmacol.Exp.Ther_334_863 |
| Author(s) : Malysz J , Anderson DJ , Gronlien JH , Ji J , Bunnelle WH , Hakerud M , Thorin-Hagene K , Ween H , Helfrich R , Hu M , Gubbins E , Gopalakrishnan S , Puttfarcken PS , Briggs CA , Li J , Meyer MD , Dyhring T , Ahring PK , Nielsen EO , Peters D , Timmermann DB , Gopalakrishnan M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :863 , 2010 |
| Abstract : |
| PubMedSearch : Malysz_2010_J.Pharmacol.Exp.Ther_334_863 |
| PubMedID: 20504915 |
| Title : In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease - Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| Author(s) : Bitner RS , Bunnelle WH , Decker MW , Drescher KU , Kohlhaas KL , Markosyan S , Marsh KC , Nikkel AL , Browman K , Radek R , Anderson DJ , Buccafusco JJ , Gopalakrishnan M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :875 , 2010 |
| Abstract : |
| PubMedSearch : Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| PubMedID: 20504913 |
| Title : Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands - Li_2010_Bioorg.Med.Chem.Lett_20_3636 |
| Author(s) : Li T , Bunnelle WH , Ryther KB , Anderson DJ , Malysz J , Helfrich R , Gronlien JH , Hakerud M , Peters D , Schrimpf MR , Gopalakrishnan M , Ji J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :3636 , 2010 |
| Abstract : |
| PubMedSearch : Li_2010_Bioorg.Med.Chem.Lett_20_3636 |
| PubMedID: 20472430 |
| Title : In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile - Malysz_2009_J.Pharmacol.Exp.Ther_330_257 |
| Author(s) : Malysz J , Gronlien JH , Anderson DJ , Hakerud M , Thorin-Hagene K , Ween H , Wetterstrand C , Briggs CA , Faghih R , Bunnelle WH , Gopalakrishnan M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 330 :257 , 2009 |
| Abstract : |
| PubMedSearch : Malysz_2009_J.Pharmacol.Exp.Ther_330_257 |
| PubMedID: 19389923 |
| Title : Poster: Profile of A-716096, a novel thiazolylidine positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor - |
| Author(s) : Donnelly-Roberts D , Malysz J , Faghih R , Gronlien H , Haakerud M , Thorin-Hagne K , Ween H , Gopalakrishnan SM , Hu M , Li J , Anderson DJ , Kohlhaas KL , Namovic M , Radek R , Robb H , Briggs CA , Bitner RS , Bunnelle WH , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 78 :912 , 2009 |
| PubMedID: |
| Title : Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor - Faghih_2009_J.Med.Chem_52_3377 |
| Author(s) : Faghih R , Gopalakrishnan SM , Gronlien JH , Malysz J , Briggs CA , Wetterstrand C , Ween H , Curtis MP , Sarris KA , Gfesser GA , El-Kouhen R , Robb HM , Radek RJ , Marsh KC , Bunnelle WH , Gopalakrishnan M |
| Ref : Journal of Medicinal Chemistry , 52 :3377 , 2009 |
| Abstract : |
| PubMedSearch : Faghih_2009_J.Med.Chem_52_3377 |
| PubMedID: 19419141 |
| Title : Poster: Role of alpha-7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-alpha (TNF-alpha) as Revealed by subtype selective agonists - |
| Author(s) : Li J , Mathieu SL , Harris R , Ji J , Anderson DJ , Malysz J , Bunnelle WH , Waring JF , Marsh KC , Murtaza A , Olson LM , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 78 :924 , 2009 |
| PubMedID: |
| Title : Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors - Briggs_2009_Br.J.Pharmacol_158_1486 |
| Author(s) : Briggs CA , Gronlien JH , Curzon P , Timmermann DB , Ween H , Thorin-Hagene K , Kerr P , Anderson DJ , Malysz J , Dyhring T , Olsen GM , Peters D , Bunnelle WH , Gopalakrishnan M |
| Ref : British Journal of Pharmacology , 158 :1486 , 2009 |
| Abstract : |
| PubMedSearch : Briggs_2009_Br.J.Pharmacol_158_1486 |
| PubMedID: 19845675 |
| Title : alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues - Briggs_2008_Br.J.Pharmacol_153_1054 |
| Author(s) : Briggs CA , Schrimpf MR , Anderson DJ , Gubbins EJ , Gronlien JH , Hakerud M , Ween H , Thorin-Hagene K , Malysz J , Li J , Bunnelle WH , Gopalakrishnan M , Meyer MD |
| Ref : British Journal of Pharmacology , 153 :1054 , 2008 |
| Abstract : |
| PubMedSearch : Briggs_2008_Br.J.Pharmacol_153_1054 |
| PubMedID: 18157163 |
| Title : Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties - Tietje_2008_CNS.Neurosci.Ther_14_65 |
| Author(s) : Tietje KR , Anderson DJ , Bitner RS , Blomme EA , Brackemeyer PJ , Briggs CA , Browman KE , Bury D , Curzon P , Drescher KU , Frost JM , Fryer RM , Fox GB , Gronlien JH , Hakerud M , Gubbins EJ , Halm S , Harris R , Helfrich RJ , Kohlhaas KL , Law D , Malysz J , Marsh KC , Martin RL , Meyer MD , Molesky AL , Nikkel AL , Otte S , Pan L , Puttfarcken PS , Radek RJ , Robb HM , Spies E , Thorin-Hagene K , Waring JF , Ween H , Xu H , Gopalakrishnan M , Bunnelle WH |
| Ref : CNS Neurosci Ther , 14 :65 , 2008 |
| Abstract : |
| PubMedSearch : Tietje_2008_CNS.Neurosci.Ther_14_65 |
| PubMedID: 18482100 |
| Title : A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models - Ji_2007_Biochem.Pharmacol_74(8)_1253 |
| Author(s) : Ji J , Bunnelle WH , Anderson DJ , Faltynek C , Dyhring T , Ahring PK , Rueter LE , Curzon P , Buckley MJ , Marsh KC , Kempf-Grote A , Meyer MD |
| Ref : Biochemical Pharmacology , 74 :1253 , 2007 |
| Abstract : |
| PubMedSearch : Ji_2007_Biochem.Pharmacol_74(8)_1253 |
| PubMedID: 17854775 |
| Title : Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1\/2 and CREB phosphorylation pathways - Bitner_2007_J.Neurosci_27_10578 |
| Author(s) : Bitner RS , Bunnelle WH , Anderson DJ , Briggs CA , Buccafusco JJ , Curzon P , Decker MW , Frost JM , Gronlien JH , Gubbins E , Li J , Malysz J , Markosyan S , Marsh K , Meyer MD , Nikkel AL , Radek RJ , Robb HM , Timmermann DB , Sullivan JP , Gopalakrishnan M |
| Ref : Journal of Neuroscience , 27 :10578 , 2007 |
| Abstract : |
| PubMedSearch : Bitner_2007_J.Neurosci_27_10578 |
| PubMedID: 17898229 |