Gopalakrishnan M

General

Full name : Gopalakrishnan Murali

First name : Murali

Mail : Department of Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois

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City :

Country : USA

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References (71)

Title : Effects of alpha7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis - Kohlhaas_2012_Psychopharmacology.(Berl)_220_823
Author(s) : Kohlhaas KL , Bitner RS , Gopalakrishnan M , Rueter LE
Ref : Psychopharmacology (Berl) , 220 :823 , 2012
Abstract :
PubMedSearch : Kohlhaas_2012_Psychopharmacology.(Berl)_220_823
PubMedID: 22038534

Title : SAR of alpha7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore - Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633
Author(s) : Schrimpf MR , Sippy KB , Briggs CA , Anderson DJ , Li T , Ji J , Frost JM , Surowy CS , Bunnelle WH , Gopalakrishnan M , Meyer MD
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1633 , 2012
Abstract :
PubMedSearch : Schrimpf_2012_Bioorg.Med.Chem.Lett_22_1633
PubMedID: 22281189

Title : Effects of the novel alpha7 nicotinic acetylcholine receptor agonist ABT-107 on sensory gating in DBA\/2 mice: pharmacodynamic characterization - Radek_2012_J.Pharmacol.Exp.Ther_343_736
Author(s) : Radek RJ , Robb HM , Stevens KE , Gopalakrishnan M , Bitner RS
Ref : Journal of Pharmacology & Experimental Therapeutics , 343 :736 , 2012
Abstract :
PubMedSearch : Radek_2012_J.Pharmacol.Exp.Ther_343_736
PubMedID: 22988063

Title : Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent alpha4beta2 nicotinic acetylcholine receptor ligands - Scanio_2011_J.Med.Chem_54_7678
Author(s) : Scanio MJ , Shi L , Bunnelle WH , Anderson DJ , Helfrich RJ , Malysz J , Thorin-Hagene KK , Van Handel CE , Marsh KC , Lee CH , Gopalakrishnan M
Ref : Journal of Medicinal Chemistry , 54 :7678 , 2011
Abstract :
PubMedSearch : Scanio_2011_J.Med.Chem_54_7678
PubMedID: 21962147

Title : alpha4beta2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of alpha4beta2 nAChR agonists in pain - Lee_2011_Biochem.Pharmacol_82(8)_959
Author(s) : Lee CH , Zhu C , Malysz J , Campbell T , Shaughnessy T , Honore P , Polakowski J , Gopalakrishnan M
Ref : Biochemical Pharmacology , 82 :959 , 2011
Abstract :
PubMedSearch : Lee_2011_Biochem.Pharmacol_82(8)_959
PubMedID: 21763685

Title : Role of alpha7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-alpha (TNF-alpha) as revealed by subtype selective agonists - Li_2011_J.Neuroimmunol_239_37
Author(s) : Li J , Mathieu SL , Harris R , Ji J , Anderson DJ , Malysz J , Bunnelle WH , Waring JF , Marsh KC , Murtaza A , Olson LM , Gopalakrishnan M
Ref : Journal of Neuroimmunology , 239 :37 , 2011
Abstract :
PubMedSearch : Li_2011_J.Neuroimmunol_239_37
PubMedID: 21911260

Title : Potentiation of analgesic efficacy but not side effects: co-administration of an alpha4beta2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats - Zhu_2011_Biochem.Pharmacol_82(8)_967
Author(s) : Zhu CZ , Chin CL , Rustay NR , Zhong C , Mikusa J , Chandran P , Salyers A , Gomez E , Simler G , Lewis LG , Gauvin D , Baker S , Pai M , Tovcimak A , Brown J , Komater V , Fox GB , Decker MW , Jacobson PB , Gopalakrishnan M , Lee CH , Honore P
Ref : Biochemical Pharmacology , 82 :967 , 2011
Abstract :
PubMedSearch : Zhu_2011_Biochem.Pharmacol_82(8)_967
PubMedID: 21620806

Title : Poster: In Vitro neuroprotective effects of ABT-779, a positive allosteric modulator of alpha7 nAChRs -
Author(s) : Hu M , Li J , Malysz J , Esbenshade TA , Lee C-H , Gopalakrishnan M
Ref : Biochemical Pharmacology , 82 :1042 , 2011
PubMedID:

Title : Poster: alpha7 NNR allosteric modulation in behavioral models of cognition -
Author(s) : Kohlhaas KL , Robb H , Roderwald V , Markosyan S , Salte K , Bitner RS , Mohler E , Terry AV, Jr. , Buccafusco JJ , Rueter LE , Lee L , Gopalakrishnan M
Ref : Biochemical Pharmacology , 82 :1042 , 2011
PubMedID:

Title : Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science--Editorial Comments -
Author(s) : Donnelly-Roberts D , Bertrand D , Gopalakrishnan M
Ref : Biochemical Pharmacology , 82 :797 , 2011
PubMedID: 21600889

Title : Poster: In vitro pharmacological characterization of ABT-779, a novel positive allosteric modulator of alpha7 nAChRs -
Author(s) : Malysz J , Gronlien JH , Briggs CA , Anderson DJ , El-Kouhen R , Drescher K , Ween H , Thorin-Hagene K , Mortell K , Lee C-H , Gopalakrishnan M
Ref : Biochemical Pharmacology , 82 :1030 , 2011
PubMedID:

Title : Poster: A-582941, a pro-cognitive alpha7 nAChR agonist, differentially modulates mitochondrial membrane potential -
Author(s) : Namovic M , Hu M , Abraham V , Towne D , Lee C-H , Gopalakrishnan M , Esbenshade T , Donnelly-Roberts D
Ref : Biochemical Pharmacology , 82 :1027 , 2011
PubMedID:

Title : Functional characterization and high-throughput screening of positive allosteric modulators of alpha7 nicotinic acetylcholine receptors in IMR-32 neuroblastoma cells - Gopalakrishnan_2011_Assay.Drug.Dev.Technol_9_635
Author(s) : Gopalakrishnan SM , Philip BM , Gronlien JH , Malysz J , Anderson DJ , Gopalakrishnan M , Warrior U , Burns DJ
Ref : Assay Drug Dev Technol , 9 :635 , 2011
Abstract :
PubMedSearch : Gopalakrishnan_2011_Assay.Drug.Dev.Technol_9_635
PubMedID: 21309712

Title : Importance of M2-M3 loop in governing properties of genistein at the alpha7 nicotinic acetylcholine receptor inferred from alpha7\/5-HT3A chimera - Gronlien_2010_Eur.J.Pharmacol_647_37
Author(s) : Gronlien JH , Ween H , Thorin-Hagene K , Cassar S , Li J , Briggs CA , Gopalakrishnan M , Malysz J
Ref : European Journal of Pharmacology , 647 :37 , 2010
Abstract :
PubMedSearch : Gronlien_2010_Eur.J.Pharmacol_647_37
PubMedID: 20816816

Title : Alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells - Gubbins_2010_Brain.Res_1328_1
Author(s) : Gubbins EJ , Gopalakrishnan M , Li J
Ref : Brain Research , 1328 :1 , 2010
Abstract :
PubMedSearch : Gubbins_2010_Brain.Res_1328_1
PubMedID: 20211606

Title : In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107 - Malysz_2010_J.Pharmacol.Exp.Ther_334_863
Author(s) : Malysz J , Anderson DJ , Gronlien JH , Ji J , Bunnelle WH , Hakerud M , Thorin-Hagene K , Ween H , Helfrich R , Hu M , Gubbins E , Gopalakrishnan S , Puttfarcken PS , Briggs CA , Li J , Meyer MD , Dyhring T , Ahring PK , Nielsen EO , Peters D , Timmermann DB , Gopalakrishnan M
Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :863 , 2010
Abstract :
PubMedSearch : Malysz_2010_J.Pharmacol.Exp.Ther_334_863
PubMedID: 20504915

Title : Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells - Ween_2010_Neurochem.Int_57_269
Author(s) : Ween H , Thorin-Hagene K , Andersen E , Gronlien JH , Lee CH , Gopalakrishnan M , Malysz J
Ref : Neurochem Int , 57 :269 , 2010
Abstract :
PubMedSearch : Ween_2010_Neurochem.Int_57_269
PubMedID: 20558224

Title : In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease - Bitner_2010_J.Pharmacol.Exp.Ther_334_875
Author(s) : Bitner RS , Bunnelle WH , Decker MW , Drescher KU , Kohlhaas KL , Markosyan S , Marsh KC , Nikkel AL , Browman K , Radek R , Anderson DJ , Buccafusco JJ , Gopalakrishnan M
Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :875 , 2010
Abstract :
PubMedSearch : Bitner_2010_J.Pharmacol.Exp.Ther_334_875
PubMedID: 20504913

Title : Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands - Li_2010_Bioorg.Med.Chem.Lett_20_3636
Author(s) : Li T , Bunnelle WH , Ryther KB , Anderson DJ , Malysz J , Helfrich R , Gronlien JH , Hakerud M , Peters D , Schrimpf MR , Gopalakrishnan M , Ji J
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :3636 , 2010
Abstract :
PubMedSearch : Li_2010_Bioorg.Med.Chem.Lett_20_3636
PubMedID: 20472430

Title : Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor - Mortell_2010_Bioorg.Med.Chem.Lett_20_104
Author(s) : Mortell KH , Schrimpf MR , Bunnelle WH , Anderson DJ , Gronlien JH , Hagene KT , Gopalakrishnan M
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :104 , 2010
Abstract :
PubMedSearch : Mortell_2010_Bioorg.Med.Chem.Lett_20_104
PubMedID: 19954975

Title : Poster: In vitro pharmacological profile of a novel alpha4\/beta2 positive allosteric modulator NS9283 (A-969933) -
Author(s) : Malysz J , Dyhring T , Ahring PK , Olsen GM , Peters D , Gronlien JH , Wetterstrand C , Ween H , Haakerud M , Thorin-Hagene K , Andersen E , Anderson DJ , Hu M , Kroeger PE , Lee CHL , Gopalakrishnan M , Timmermann DB
Ref : Biochemical Pharmacology , 78 :919 , 2009
PubMedID:

Title : Poster: Selectivity of ABT-089 for alpha4\/beta2* and alpha6\/beta2 nicotinic acetylcholine receptors in brain -
Author(s) : Marks MJ , Wageman CR , Grady SR , Gopalakrishnan M , Briggs CA
Ref : Biochemical Pharmacology , 78 :910 , 2009
PubMedID:

Title : Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons - Hu_2009_Br.J.Pharmacol_158_1857
Author(s) : Hu M , Gopalakrishnan M , Li J
Ref : British Journal of Pharmacology , 158 :1857 , 2009
Abstract :
PubMedSearch : Hu_2009_Br.J.Pharmacol_158_1857
PubMedID: 20050184

Title : Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination - Anderson_2009_Biochem.Pharmacol_78(7)_844
Author(s) : Anderson DJ , Malysz J , Gronlien JH , El Kouhen R , Hakerud M , Wetterstrand C , Briggs CA , Gopalakrishnan M
Ref : Biochemical Pharmacology , 78 :844 , 2009
Abstract :
PubMedSearch : Anderson_2009_Biochem.Pharmacol_78(7)_844
PubMedID: 19555668

Title : Poster: alpha3* and alpha7* nAChR mediated Ca2+ transient generation in neuroblastoma IMR-32 cells -
Author(s) : Ween H , Thorin-Hagene K , Andersen E , Gronlien JH , Lee L , Gopalakrishnan M , Malysz J
Ref : Biochemical Pharmacology , 78 :904 , 2009
PubMedID:

Title : Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science--editorial perspective -
Author(s) : Bertrand D , Gopalakrishnan M , Donnelly-Roberts D
Ref : Biochemical Pharmacology , 78 :657 , 2009
PubMedID: 19576180

Title : Poster: In vivo characterization of the co-administration of alpha4\/beta2 neuronal nicotinic receptor agonist and positive allosteric modulator in experimental pain in rats -
Author(s) : Zhu CZ , Chin C-l , Zhong C , Mikusa J , Chandran P , Salyers A , Wensink E , Silmer G , Lewis LG , Gauvin D , Baker S , Tovcimak A , Brown J , Rustay N , Fox GB , Decker MW , Lee C-H , Gopalakrishnan M , Honore P
Ref : Biochemical Pharmacology , 78 :920 , 2009
PubMedID:

Title : Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo - Bitner_2009_Brain.Res_1265_65
Author(s) : Bitner RS , Nikkel AL , Markosyan S , Otte S , Puttfarcken P , Gopalakrishnan M
Ref : Brain Research , 1265 :65 , 2009
Abstract :
PubMedSearch : Bitner_2009_Brain.Res_1265_65
PubMedID: 19230830

Title : Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors - Briggs_2009_Br.J.Pharmacol_158_1486
Author(s) : Briggs CA , Gronlien JH , Curzon P , Timmermann DB , Ween H , Thorin-Hagene K , Kerr P , Anderson DJ , Malysz J , Dyhring T , Olsen GM , Peters D , Bunnelle WH , Gopalakrishnan M
Ref : British Journal of Pharmacology , 158 :1486 , 2009
Abstract :
PubMedSearch : Briggs_2009_Br.J.Pharmacol_158_1486
PubMedID: 19845675

Title : In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile - Malysz_2009_J.Pharmacol.Exp.Ther_330_257
Author(s) : Malysz J , Gronlien JH , Anderson DJ , Hakerud M , Thorin-Hagene K , Ween H , Wetterstrand C , Briggs CA , Faghih R , Bunnelle WH , Gopalakrishnan M
Ref : Journal of Pharmacology & Experimental Therapeutics , 330 :257 , 2009
Abstract :
PubMedSearch : Malysz_2009_J.Pharmacol.Exp.Ther_330_257
PubMedID: 19389923

Title : Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station - Malysz_2009_Assay.Drug.Dev.Technol_7_374
Author(s) : Malysz J , Gronlien JH , Timmermann DB , Hakerud M , Thorin-Hagene K , Ween H , Trumbull JD , Xiong Y , Briggs CA , Ahring PK , Dyhring T , Gopalakrishnan M
Ref : Assay Drug Dev Technol , 7 :374 , 2009
Abstract :
PubMedSearch : Malysz_2009_Assay.Drug.Dev.Technol_7_374
PubMedID: 19689206

Title : Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain - Marks_2009_Biochem.Pharmacol_78(7)_795
Author(s) : Marks MJ , Wageman CR , Grady SR , Gopalakrishnan M , Briggs CA
Ref : Biochemical Pharmacology , 78 :795 , 2009
Abstract :
PubMedSearch : Marks_2009_Biochem.Pharmacol_78(7)_795
PubMedID: 19481067

Title : Poster: Radioligand binding characterization of [3H]-A-998679: A novel positive allosteric modulator of alpha4\/beta2 nAChRs -
Author(s) : Anderson DJ , Vaidyanathan S , Namovic M , Donnelly-Roberts D , Lee L , Gopalakrishnan M
Ref : Biochemical Pharmacology , 78 :903 , 2009
PubMedID:

Title : Poster: Profile of A-716096, a novel thiazolylidine positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor -
Author(s) : Donnelly-Roberts D , Malysz J , Faghih R , Gronlien H , Haakerud M , Thorin-Hagne K , Ween H , Gopalakrishnan SM , Hu M , Li J , Anderson DJ , Kohlhaas KL , Namovic M , Radek R , Robb H , Briggs CA , Bitner RS , Bunnelle WH , Gopalakrishnan M
Ref : Biochemical Pharmacology , 78 :912 , 2009
PubMedID:

Title : Poster: Positive allosteric modulation of alpha4\/beta2 nicotinic receptors potentiates some CNS effects of the alpha4\/beta2 agonist, ABT-594 -
Author(s) : Franklin SR , Mohler EG , Komater VA , Robb H , Radek RJ , Rustay NR , Brown JW , Gopalakrishnan M , Decker MW , Rueter LE
Ref : Biochemical Pharmacology , 78 :921 , 2009
PubMedID:

Title : Pharmacology of alpha7 nicotinic acetylcholine receptor mediated extracellular signal-regulated kinase signalling in PC12 cells - El Kouhen_2009_Br.J.Pharmacol_156_638
Author(s) : El Kouhen R , Hu M , Anderson DJ , Li J , Gopalakrishnan M
Ref : British Journal of Pharmacology , 156 :638 , 2009
Abstract :
PubMedSearch : El Kouhen_2009_Br.J.Pharmacol_156_638
PubMedID: 19226255

Title : Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor - Faghih_2009_J.Med.Chem_52_3377
Author(s) : Faghih R , Gopalakrishnan SM , Gronlien JH , Malysz J , Briggs CA , Wetterstrand C , Ween H , Curtis MP , Sarris KA , Gfesser GA , El-Kouhen R , Robb HM , Radek RJ , Marsh KC , Bunnelle WH , Gopalakrishnan M
Ref : Journal of Medicinal Chemistry , 52 :3377 , 2009
Abstract :
PubMedSearch : Faghih_2009_J.Med.Chem_52_3377
PubMedID: 19419141

Title : Poster: Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: Lack of mechanism-based evidence for cytotoxicity in PC12 cells and rat primary cortical neurons -
Author(s) : Hu M , Gopalakrishnan M , Li J
Ref : Biochemical Pharmacology , 78 :904 , 2009
PubMedID:

Title : Poster: Improving the efficacy-tolerability profile of nAChR agonists for the treatment of neuropathic pain in combination with positive allosteric modulators -
Author(s) : Lee C-H , Zhu C , Campbell T , Shaughnessy T , Honore P , Polakowski J , Gopalakrishnan M
Ref : Biochemical Pharmacology , 78 :920 , 2009
PubMedID:

Title : Poster: Role of alpha-7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-alpha (TNF-alpha) as Revealed by subtype selective agonists -
Author(s) : Li J , Mathieu SL , Harris R , Ji J , Anderson DJ , Malysz J , Bunnelle WH , Waring JF , Marsh KC , Murtaza A , Olson LM , Gopalakrishnan M
Ref : Biochemical Pharmacology , 78 :924 , 2009
PubMedID:

Title : [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]hept ane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain - Anderson_2008_J.Pharmacol.Exp.Ther_324_179
Author(s) : Anderson DJ , Bunnelle W , Surber B , Du J , Surowy C , Tribollet E , Marguerat A , Bertrand D , Gopalakrishnan M
Ref : Journal of Pharmacology & Experimental Therapeutics , 324 :179 , 2008
Abstract :
PubMedSearch : Anderson_2008_J.Pharmacol.Exp.Ther_324_179
PubMedID: 17959745

Title : Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells - Hu_2008_J.Neurochem_106_1371
Author(s) : Hu M , Waring JF , Gopalakrishnan M , Li J
Ref : Journal of Neurochemistry , 106 :1371 , 2008
Abstract :
PubMedSearch : Hu_2008_J.Neurochem_106_1371
PubMedID: 18485099

Title : Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties - Tietje_2008_CNS.Neurosci.Ther_14_65
Author(s) : Tietje KR , Anderson DJ , Bitner RS , Blomme EA , Brackemeyer PJ , Briggs CA , Browman KE , Bury D , Curzon P , Drescher KU , Frost JM , Fryer RM , Fox GB , Gronlien JH , Hakerud M , Gubbins EJ , Halm S , Harris R , Helfrich RJ , Kohlhaas KL , Law D , Malysz J , Marsh KC , Martin RL , Meyer MD , Molesky AL , Nikkel AL , Otte S , Pan L , Puttfarcken PS , Radek RJ , Robb HM , Spies E , Thorin-Hagene K , Waring JF , Ween H , Xu H , Gopalakrishnan M , Bunnelle WH
Ref : CNS Neurosci Ther , 14 :65 , 2008
Abstract :
PubMedSearch : Tietje_2008_CNS.Neurosci.Ther_14_65
PubMedID: 18482100

Title : Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment - Bertrand_2008_Mol.Pharmacol_74_1407
Author(s) : Bertrand D , Bertrand S , Cassar S , Gubbins E , Li J , Gopalakrishnan M
Ref : Molecular Pharmacology , 74 :1407 , 2008
Abstract :
PubMedSearch : Bertrand_2008_Mol.Pharmacol_74_1407
PubMedID: 18678621

Title : Allosteric modulators of the alpha7 nicotinic acetylcholine receptor -
Author(s) : Faghih R , Gopalakrishnan M , Briggs CA
Ref : Journal of Medicinal Chemistry , 51 :701 , 2008
PubMedID: 18198823

Title : Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist - Waring_2008_Neurosci.Res_60_266
Author(s) : Waring JF , Abel S , Li J , Bitner RS , Nikkel AL , Blomme EA , Anderson DJ , Gopalakrishnan M
Ref : Neurosci Res , 60 :266 , 2008
Abstract :
PubMedSearch : Waring_2008_Neurosci.Res_60_266
PubMedID: 18164502

Title : The potential of neuronal nicotinic acetylcholine receptor agonists for treating CNS conditions - Decker_2008_Expert.Opin.Drug.Discov_3_1027
Author(s) : Decker MW , Gopalakrishnan M , Meyer MD
Ref : Expert Opin Drug Discov , 3 :1027 , 2008
Abstract :
PubMedSearch : Decker_2008_Expert.Opin.Drug.Discov_3_1027
PubMedID: 23506178

Title : alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues - Briggs_2008_Br.J.Pharmacol_153_1054
Author(s) : Briggs CA , Schrimpf MR , Anderson DJ , Gubbins EJ , Gronlien JH , Hakerud M , Ween H , Thorin-Hagene K , Malysz J , Li J , Bunnelle WH , Gopalakrishnan M , Meyer MD
Ref : British Journal of Pharmacology , 153 :1054 , 2008
Abstract :
PubMedSearch : Briggs_2008_Br.J.Pharmacol_153_1054
PubMedID: 18157163

Title : Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes - Gronlien_2007_Mol.Pharmacol_72_715
Author(s) : Gronlien JH , Hakerud M , Ween H , Thorin-Hagene K , Briggs CA , Gopalakrishnan M , Malysz J
Ref : Molecular Pharmacology , 72 :715 , 2007
Abstract :
PubMedSearch : Gronlien_2007_Mol.Pharmacol_72_715
PubMedID: 17565004

Title : High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands - Hu_2007_Brain.Res_1151_227
Author(s) : Hu M , Schurdak ME , Puttfarcken PS , El Kouhen R , Gopalakrishnan M , Li J
Ref : Brain Research , 1151 :227 , 2007
Abstract :
PubMedSearch : Hu_2007_Brain.Res_1151_227
PubMedID: 17449017

Title : An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo - Timmermann_2007_J.Pharmacol.Exp.Ther_323_294
Author(s) : Timmermann DB , Gronlien JH , Kohlhaas KL , Nielsen EO , Dam E , Jorgensen TD , Ahring PK , Peters D , Holst D , Christensen JK , Malysz J , Briggs CA , Gopalakrishnan M , Olsen GM
Ref : Journal of Pharmacology & Experimental Therapeutics , 323 :294 , 2007
Abstract :
PubMedSearch : Timmermann_2007_J.Pharmacol.Exp.Ther_323_294
PubMedID: 17625074

Title : Allosteric modulation of nicotinic acetylcholine receptors - Bertrand_2007_Biochem.Pharmacol_74(8)_1155
Author(s) : Bertrand D , Gopalakrishnan M
Ref : Biochemical Pharmacology , 74 :1155 , 2007
Abstract :
PubMedSearch : Bertrand_2007_Biochem.Pharmacol_74(8)_1155
PubMedID: 17707779

Title : Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1\/2 and CREB phosphorylation pathways - Bitner_2007_J.Neurosci_27_10578
Author(s) : Bitner RS , Bunnelle WH , Anderson DJ , Briggs CA , Buccafusco JJ , Curzon P , Decker MW , Frost JM , Gronlien JH , Gubbins E , Li J , Malysz J , Markosyan S , Marsh K , Meyer MD , Nikkel AL , Radek RJ , Robb HM , Timmermann DB , Sullivan JP , Gopalakrishnan M
Ref : Journal of Neuroscience , 27 :10578 , 2007
Abstract :
PubMedSearch : Bitner_2007_J.Neurosci_27_10578
PubMedID: 17898229

Title : Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys - Buccafusco_2007_Biochem.Pharmacol_74(8)_1202
Author(s) : Buccafusco JJ , Terry AV, Jr. , Decker MW , Gopalakrishnan M
Ref : Biochemical Pharmacology , 74 :1202 , 2007
Abstract :
PubMedSearch : Buccafusco_2007_Biochem.Pharmacol_74(8)_1202
PubMedID: 17706609

Title : Advances in the discovery of novel positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor - Faghih_2007_Recent.Pat.CNS.Drug.Discov_2_99
Author(s) : Faghih R , Gfesser GA , Gopalakrishnan M
Ref : Recent Pat CNS Drug Discov , 2 :99 , 2007
Abstract :
PubMedSearch : Faghih_2007_Recent.Pat.CNS.Drug.Discov_2_99
PubMedID: 18221220

Title : Nicotinic acetylcholine receptors as therapeutic targets: emerging frontiers in basic research and clinical science - editorial comments -
Author(s) : Gopalakrishnan M , Bertrand D , Williams M
Ref : Biochemical Pharmacology , 74 :1091 , 2007
PubMedID: 17889037

Title : Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment - Curzon_2006_Neurosci.Lett_410_15
Author(s) : Curzon P , Anderson DJ , Nikkel AL , Fox GB , Gopalakrishnan M , Decker MW , Bitner RS
Ref : Neuroscience Letters , 410 :15 , 2006
Abstract :
PubMedSearch : Curzon_2006_Neurosci.Lett_410_15
PubMedID: 17055644

Title : Alpha4beta2 nicotinic receptor stimulation contributes to the effects of nicotine in the DBA\/2 mouse model of sensory gating - Radek_2006_Psychopharmacology.(Berl)_187_47
Author(s) : Radek RJ , Miner HM , Bratcher NA , Decker MW , Gopalakrishnan M , Bitner RS
Ref : Psychopharmacology (Berl) , 187 :47 , 2006
Abstract :
PubMedSearch : Radek_2006_Psychopharmacology.(Berl)_187_47
PubMedID: 16767415

Title : ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders - Rueter_2004_CNS.Drug.Rev_10_167
Author(s) : Rueter LE , Anderson DJ , Briggs CA , Donnelly-Roberts D , Gintant GA , Gopalakrishnan M , Lin NH , Osinski MA , Reinhart GA , Buckley MJ , Martin RL , McDermott JS , Preusser LC , Seifert TR , Su Z , Cox BF , Decker MW , Sullivan JP
Ref : CNS Drug Rev , 10 :167 , 2004
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PubMedSearch : Rueter_2004_CNS.Drug.Rev_10_167
PubMedID: 15179445

Title : Neuronal nicotinic receptors: filling the void? -
Author(s) : Gopalakrishnan M , Bitner RS
Ref : American Journal of Physiology Regul Integr Comp Physiol , 285 :R21 , 2003
PubMedID: 12793987

Title : Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant - Briggs_1999_Eur.J.Pharmacol_366_301
Author(s) : Briggs CA , McKenna DG , Monteggia LM , Touma E , Roch JM , Arneric SP , Gopalakrishnan M , Sullivan JP
Ref : European Journal of Pharmacology , 366 :301 , 1999
Abstract :
PubMedSearch : Briggs_1999_Eur.J.Pharmacol_366_301
PubMedID: 10082212

Title : Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands - Molinari_1998_Eur.J.Pharmacol_347_131
Author(s) : Molinari EJ , Delbono O , Messi ML , Renganathan M , Arneric SP , Sullivan JP , Gopalakrishnan M
Ref : European Journal of Pharmacology , 347 :131 , 1998
Abstract :
PubMedSearch : Molinari_1998_Eur.J.Pharmacol_347_131
PubMedID: 9650859

Title : ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties - Sullivan_1997_J.Pharmacol.Exp.Ther_283_235
Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Xue IC , Piattoni-Kaplan M , Molinari E , Campbell JE , McKenna DG , Gunn DE , Lin NH , Ryther KB , He Y , Holladay MW , Wonnacott S , Williams M , Arneric SP
Ref : Journal of Pharmacology & Experimental Therapeutics , 283 :235 , 1997
Abstract :
PubMedSearch : Sullivan_1997_J.Pharmacol.Exp.Ther_283_235
PubMedID: 9336329

Title : Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo - Briggs_1997_Pharmacol.Biochem.Behav_57_231
Author(s) : Briggs CA , Anderson DJ , Brioni JD , Buccafusco JJ , Buckley MJ , Campbell JE , Decker MW , Donnelly-Roberts D , Elliott RL , Gopalakrishnan M , Holladay MW , Hui YH , Jackson WJ , Kim DJ , Marsh KC , O'Neill A , Prendergast MA , Ryther KB , Sullivan JP , Arneric SP
Ref : Pharmacol Biochem Behav , 57 :231 , 1997
Abstract :
PubMedSearch : Briggs_1997_Pharmacol.Biochem.Behav_57_231
PubMedID: 9164577

Title : Activation of the recombinant human alpha 7 nicotinic acetylcholine receptor significantly raises intracellular free calcium - Delbono_1997_J.Pharmacol.Exp.Ther_280_428
Author(s) : Delbono O , Gopalakrishnan M , Renganathan M , Monteggia LM , Messi ML , Sullivan JP
Ref : Journal of Pharmacology & Experimental Therapeutics , 280 :428 , 1997
Abstract :
PubMedSearch : Delbono_1997_J.Pharmacol.Exp.Ther_280_428
PubMedID: 8996225

Title : Regulation of human alpha4beta2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways - Gopalakrishnan_1997_Mol.Pharmacol_52_524
Author(s) : Gopalakrishnan M , Molinari EJ , Sullivan JP
Ref : Molecular Pharmacology , 52 :524 , 1997
Abstract :
PubMedSearch : Gopalakrishnan_1997_Mol.Pharmacol_52_524
PubMedID: 9281615

Title : A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand - Sullivan_1996_Neuropharmacol_35_725
Author(s) : Sullivan JP , Donnelly-Roberts D , Briggs CA , Anderson DJ , Gopalakrishnan M , Piattoni-Kaplan M , Campbell JE , McKenna DG , Molinari E , Hettinger AM , Garvey DS , Wasicak JT , Holladay MW , Williams M , Arneric SP
Ref : Neuropharmacology , 35 :725 , 1996
Abstract :
PubMedSearch : Sullivan_1996_Neuropharmacol_35_725
PubMedID: 8887981

Title : Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study - Buisson_1996_J.Neurosci_16_7880
Author(s) : Buisson B , Gopalakrishnan M , Arneric SP , Sullivan JP , Bertrand D
Ref : Journal of Neuroscience , 16 :7880 , 1996
Abstract :
PubMedSearch : Buisson_1996_J.Neurosci_16_7880
PubMedID: 8987816

Title : Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor - Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289
Author(s) : Gopalakrishnan M , Monteggia LM , Anderson DJ , Molinari EJ , Piattoni-Kaplan M , Donnelly-Roberts D , Arneric SP , Sullivan JP
Ref : Journal of Pharmacology & Experimental Therapeutics , 276 :289 , 1996
Abstract :
PubMedSearch : Gopalakrishnan_1996_J.Pharmacol.Exp.Ther_276_289
PubMedID: 8558445

Title : Cloning and transient expression of genes encoding the human alpha 4 and beta 2 neuronal nicotinic acetylcholine receptor (nAChR) subunits - Monteggia_1995_Gene_155_189
Author(s) : Monteggia LM , Gopalakrishnan M , Touma E , Idler KB , Nash N , Arneric SP , Sullivan JP , Giordano T
Ref : Gene , 155 :189 , 1995
Abstract :
PubMedSearch : Monteggia_1995_Gene_155_189
PubMedID: 7721089

Title : Stable expression and pharmacological properties of the human alpha 7 nicotinic acetylcholine receptor - Gopalakrishnan_1995_Eur.J.Pharmacol_290_237
Author(s) : Gopalakrishnan M , Buisson B , Touma E , Giordano T , Campbell JE , Hu IC , Donnelly-Roberts D , Arneric SP , Bertrand D , Sullivan JP
Ref : European Journal of Pharmacology , 290 :237 , 1995
Abstract :
PubMedSearch : Gopalakrishnan_1995_Eur.J.Pharmacol_290_237
PubMedID: 7589218