Lodovici_1997_Toxicology_117_55

Reference

Title : Oxidative liver DNA damage in rats treated with pesticide mixtures - Lodovici_1997_Toxicology_117_55
Author(s) : Lodovici M , Casalini C , Briani C , Dolara P
Ref : Toxicology , 117 :55 , 1997
Abstract : Oxidative damage was quantified in the liver of rats by measuring the levels of 8-OH-2-deoxyguanosine (8-OH-2DG) relative to 2-deoxyguanosine in DNA after treating rats for 10 days at a total dose of 1 mg/kg/day with a mixture of the 15 pesticides most commonly found in Italian foods (comprised of dithiocarbamate, benomyl, procymidone, methidathion, chlorpyrifos-ethyl, parathion-methyl, chlorpropham, parathion, vinclozolin, chlorfenvinphos, pirimiphos ethyl, thiabendazole, fenarimol, diphenylamine and chlorothalonil). We fractionated this pesticide mixture into subgroups in order to determine which molecules, if any, induced DNA oxidative damage. The administration of diphenylamine (0.09-1.4 mg/kg/day) and chlorothalonil (0.13-1 mg/kg/day) induced a dose-dependent increase in 8-OH-2DG levels in liver DNA. The other 13 pesticides of the mixture on the contrary, did not produce oxidative liver DNA damage. These results indicate that the toxicity of low doses of pesticide mixtures present in food might be further reduced by eliminating diphenylamine and chlorothalonil.
ESTHER : Lodovici_1997_Toxicology_117_55
PubMedSearch : Lodovici_1997_Toxicology_117_55
PubMedID: 9020199

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Citations formats

Lodovici M, Casalini C, Briani C, Dolara P (1997)
Oxidative liver DNA damage in rats treated with pesticide mixtures
Toxicology 117 :55

Lodovici M, Casalini C, Briani C, Dolara P (1997)
Toxicology 117 :55