Type : Trichloro, Insecticide, Organophosphate, Sulfur Compound, Organothiophosphate, OPIDN-OP
Chemical_Nomenclature : Phosphorothioic acid O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester
Canonical SMILES : CCOP(=S)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl
InChI : InChI=1S\/C9H11Cl3NO3PS\/c1-3-14-17(18,15-4-2)16-9-7(11)5-6(10)8(12)13-9\/h5H,3-4H2,1-2H3
InChIKey : SBPBAQFWLVIOKP-UHFFFAOYSA-N
Other name(s) : Trichlorpyrphos || Chlorpyriphos-ethyl || Chlorpyriphos || Brodan || Detmol UA || Dowco 179 || Dursban || Eradex || Lorsban || Piridane || Stipend. Brodan || killmaster || dursban 10cr || suscon || lorsban 50sl || coroban || terial || 40l || danusban || durmet || Vitashield 40EC
MW : 350.62
Formula : C9H11Cl3NO3PS
CAS_number : 2921-88-2
PubChem : 2730
UniChem : SBPBAQFWLVIOKP-UHFFFAOYSA-N
Wikipedia : Chlorpyrifos
Families : Chlorpyrifos ligand of proteins in family
ACHE
Est9X
Duf_3089
Carb_B_Arthropoda
Protein :
9acto-h1qtl0
9bact-q0gpb3
helam-d5g3e0
| Title : Simplified assessment of acetylcholinesterase inhibition by environmental organophosphorus pesticides - Zhu_2025_Chem.Biol.Interact_421_111722 |
| Author(s) : Zhu R , Liu Y , Ma Y , Xu T , Yang G , Zandona A , Cadez T , Kovarik Z , Xie HQ , Xu L , Zhao B |
| Ref : Chemico-Biological Interactions , 421 :111722 , 2025 |
| Abstract : |
| PubMedSearch : Zhu_2025_Chem.Biol.Interact_421_111722 |
| PubMedID: 40912351 |
| Gene_locus related to this paper: eleel-ACHE , human-ACHE |
| Title : Evaluation of developmental toxicity of chlorpyrifos through new approach methodologies: a systematic review - Coppola_2025_Arch.Toxicol__ |
| Author(s) : Coppola L , Lori G , Tait S , Sogorb MA , Estevan C |
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| Abstract : |
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| Title : Heterologous expression, biochemical characterization and prospects for insecticide biosensing potential of carboxylesterase Ha006a from Helicoverpa armigera - Kaur_2024_Pestic.Biochem.Physiol_200_105844 |
| Author(s) : Kaur H , Rode S , Lonare S , Demiwal P , Narasimhappa P , Arun E , Kumar R , Das J , Ramamurthy PC , Sircar D , Sharma AK |
| Ref : Pestic Biochem Physiol , 200 :105844 , 2024 |
| Abstract : |
| PubMedSearch : Kaur_2024_Pestic.Biochem.Physiol_200_105844 |
| PubMedID: 38582571 |
| Gene_locus related to this paper: helam-d5g3e0 |
| Title : Molecular docking analysis of chlorpyrifos at the human alpha7-nAChR and its potential relationship with neurocytoxicity in SH-SY5Y cells - Ramirez-Cando_2024_J.Environ.Sci.Health.B__1 |
| Author(s) : Ramirez-Cando LJ , Rodriguez-Cazar LG , Acosta-Tobar LA , Ballaz SJ |
| Ref : J Environ Sci Health B , :1 , 2024 |
| Abstract : |
| PubMedSearch : Ramirez-Cando_2024_J.Environ.Sci.Health.B__1 |
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| Title : Effect of an organophosphate insecticide on the behaviour and physiology of the spider Misumenops maculissparsus (Araneae: Thomisidae) - Romero_2024_Environ.Toxicol.Pharmacol_110_104525 |
| Author(s) : Romero S , Laino A , Gabellone C , Garcia CF |
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| Abstract : |
| PubMedSearch : Romero_2024_Environ.Toxicol.Pharmacol_110_104525 |
| PubMedID: 39111559 |
| Title : Reusable carboxylesterase immobilized in ZIF for efficient degradation of chlorpyrifos in enviromental water - Wang_2023_Pestic.Biochem.Physiol_194_105519 |
| Author(s) : Wang B , Chen J , Wu S , Fang J , Li Q , Wang G |
| Ref : Pestic Biochem Physiol , 194 :105519 , 2023 |
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| Gene_locus related to this paper: strco-estli |
| Title : Cnr1(-\/-) has minimal impact on chlorpyrifos-mediated effects in the mouse endocannabinoid system, but it does alter lipopolysaccharide-induced cytokine levels in splenocytes - Szafran_2023_Chem.Biol.Interact__110425 |
| Author(s) : Szafran BN , Nichols J , Nicaise A , Borazjani A , Carr R , Wilson JR , Ross MK , Kaplan BLF |
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| Title : Effects of chlorpyrifos on transient receptor potential channels - Li_2022_Toxicol.Lett_358_100 |
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| Title : Inhibition of Serum Esterases in Juvenile Rats Repeatedly Exposed to Low Levels of Chlorpyrifos - Mosier_2022_Int.J.Sc.Res.Environ.Sci.Toxicol_5_1 |
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| Title : Characterization of a novel hyper-thermostable and chlorpyrifos-hydrolyzing carboxylesterase EstC: A representative of the new esterase family XIX - Wang_2020_Pestic.Biochem.Physiol_170_104704 |
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| Ref : Pestic Biochem Physiol , 170 :104704 , 2020 |
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| Gene_locus related to this paper: strco-estli |
| Title : Decreased anxiety in juvenile rats following exposure to low levels of chlorpyrifos during development - Carr_2017_Neurotoxicol_59_183 |
| Author(s) : Carr RL , Armstrong NH , Buchanan AT , Eells JB , Mohammed AN , Ross MK , Nail CA |
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| Title : Exploration of the chlorpyrifos escape pathway from acylpeptide hydrolases using steered molecular dynamics simulations - Wang_2016_J.Biomol.Struct.Dyn_34_749 |
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| Gene_locus related to this paper: aerpe-APE1547 |
| Title : Induction of endocannabinoid levels in juvenile rat brain following developmental chlorpyrifos exposure - Carr_2013_Toxicol.Sci_135_193 |
| Author(s) : Carr RL , Adams AL , Kepler DR , Ward AB , Ross MK |
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| Title : Cross-resistance and possible mechanisms of chlorpyrifos resistance in Laodelphax striatellus (Fallen) - Wang_2010_Pest.Manag.Sci_66_1096 |
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| Title : Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents - Jiang_2010_Toxicol.Sci_115_183 |
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| Title : Expression of esterase gene in yeast for organophosphates biodegradation - Kambiranda_2009_Pestic.Biochem.Physiol_94_15 |
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| Gene_locus related to this paper: 9bact-q0gpb3 |
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| Gene_locus related to this paper: human-CES1 , mouse-Ces1e , ratno-Ces1e |
| Title : Determination of the reference dose for chlorpyrifos: proceedings of an expert panel - Clegg_1999_J.Toxicol.Environ.Health.B.Crit.Rev_2_211 |
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| Title : Hepatic injury and disturbed amino acid metabolism in mice following prolonged exposure to organophosphorus pesticides - Gomes_1999_Hum.Exp.Toxicol_18_33 |
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| Ref : Hum Exp Toxicol , 18 :33 , 1999 |
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| Title : Organophosphorus pesticide-induced butyrylcholinesterase inhibition and potentiation of succinylcholine toxicity in mice - Sparks_1999_J.Biochem.Mol.Toxicol_13_113 |
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| Ref : J Biochem Mol Toxicol , 13 :113 , 1999 |
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| Title : Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos - Johnson_1998_Brain.Res.Bull_45_143 |
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| Title : Comparison of the in vitro sensitivity of rat acetylcholinesterase to chlorpyrifos-oxon: what do tissue IC50 values represent? - Mortensen_1998_Toxicol.Appl.Pharmacol_148_46 |
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| Ref : Toxicol Appl Pharmacol , 148 :46 , 1998 |
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| PubMedID: 9615543 |
| Title : The organophosphate pesticide chlorpyrifos affects form deprivation myopia - Geller_1998_Invest.Ophthalmol.Vis.Sci_39_1290 |
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| Title : Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration - Dam_1998_Brain.Res.Dev.Brain.Res_108_39 |
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| PubMedID: 9693782 |
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| Ref : Toxicol Appl Pharmacol , 151 :182 , 1998 |
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| PubMedID: 9705902 |
| Title : Comparative Toxicity of Chlordane, Chlorpyrifos, and Aldicarb to Four Aquatic Testing Organisms - Moore_1998_Arch.Environ.Contam.Toxicol_34_152 |
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| PubMedID: 9469857 |
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| PubMedID: 9744190 |
| Title : Oxidative liver DNA damage in rats treated with pesticide mixtures - Lodovici_1997_Toxicology_117_55 |
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| Title : Age-related differences in parathion and chlorpyrifos toxicity in male rats: target and nontarget esterase sensitivity and cytochrome P450- mediated metabolism - Atterberry_1997_Toxicol.Appl.Pharmacol_147_411 |
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| PubMedSearch : Atterberry_1997_Toxicol.Appl.Pharmacol_147_411 |
| PubMedID: 9439736 |
| Title : [Determination of insecticide resistance and its biochemical mechanisms in 2 strains of Culex quinquefasciatus from Santiago de Cuba] - Rodriguez_1997_Rev.Cubana.Med.Trop_49_209 |
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| PubMedID: 9685989 |
| Title : Evaluation of organophosphorus pesticide residues in citrus fruits from the Valencian community (Spain) - Torres_1997_J.AOAC.Int_80_1122 |
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| Title : Distribution of organophosphate and carbamate resistance in Culex pipiens quinquefasciatus (Diptera: Culicidae) in West Africa - Chandre_1997_J.Med.Entomol_34_664 |
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| Title : Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning - Worek_1997_Hum.Exp.Toxicol_16_466 |
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| Title : Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade - Song_1997_Toxicol.Appl.Pharmacol_145_158 |
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| Title : Time course of inhibition of cholinesterase and aliesterase activities, and nonprotein sulfhydryl levels following exposure to organophosphorus insecticides in mosquitofish (Gambusia affinis) - Boone_1996_Fundam.Appl.Toxicol_29_202 |
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| Title : Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae - Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391 |
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| Title : Organophosphate resistance in Culex pipiens from Cyprus - Wirth_1996_J.Am.Mosq.Control.Assoc_12_112 |
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| Title : Organohalogen and organophosphorus pesticides in mixed feed rations: findings from FDA's domestic surveillance during fiscal years 1989-1994 - Lovell_1996_J.AOAC.Int_79_544 |
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| Title : Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyrifos - Chiappa_1995_Biochem.Pharmacol_49_955 |
| Author(s) : Chiappa S , Padilla S , Koenigsberger C , Moser V , Brimijoin S |
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| Title : Resistance to organophosphorous insecticides in Culex pipiens quinquefasciatus (Diptera: Culicidae) from Martinique - Yebakima_1995_J.Med.Entomol_32_77 |
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| Title : Inhibition and aging of channel catfish brain acetylcholinesterase following exposure to two phosphorothionate insecticides and their active metabolites - Carr_1995_J.Toxicol.Env.Health_45_325 |
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| Ref : Journal of Toxicology & Environmental Health , 45 :325 , 1995 |
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| Title : Effects of three organophosphorus insecticides in the reproductive potential of Culex quinquefasciatus - Aguilera_1995_Mem.Inst.Oswaldo.Cruz_90_411 |
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| Title : Characterization of resistance to organophosphate, carbamate, and pyrethroid insecticides in field populations of Aedes aegypti from Venezuela - Mazzarri_1995_J.Am.Mosq.Control.Assoc_11_315 |
| Author(s) : Mazzarri MB , Georghiou GP |
| Ref : J Am Mosq Control Assoc , 11 :315 , 1995 |
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| Title : Comparative developmental and maternal neurotoxicity following acute gestational exposure to chlorpyrifos in rats - Chanda_1995_J.Toxicol.Env.Health_44_189 |
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| Title : Cytogenetic effects on human lymphocytes of a mixture of fifteen pesticides commonly used in Italy - Dolara_1994_Mutat.Res_325_47 |
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| Title : Insecticide susceptibility in mosquitoes (Diptera: Culicidae) from French Polynesia - Failloux_1994_J.Med.Entomol_31_639 |
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| Title : Serum paraoxonase status: a major factor in determining resistance to organophosphates - Li_1993_J.Toxicol.Env.Health_40_337 |
| Author(s) : Li WF , Costa LG , Furlong CE |
| Ref : Journal of Toxicology & Environmental Health , 40 :337 , 1993 |
| Abstract : |
| PubMedSearch : Li_1993_J.Toxicol.Env.Health_40_337 |
| PubMedID: 7693961 |
| Title : Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet - Dolara_1993_Cell.Biol.Toxicol_9_333 |
| Author(s) : Dolara P , Vezzani A , Caderni G , Coppi C , Torricelli F |
| Ref : Cell Biol Toxicol , 9 :333 , 1993 |
| Abstract : |
| PubMedSearch : Dolara_1993_Cell.Biol.Toxicol_9_333 |
| PubMedID: 8039010 |
| Title : Urinary excretion of diethylphosphorus metabolites in persons poisoned by quinalphos or chlorpyrifos - Vasilic_1992_Arch.Environ.Contam.Toxicol_22_351 |
| Author(s) : Vasilic Z , Drevenkar V , Rumenjak V , Stengl B , Frobe Z |
| Ref : Archives of Environmental Contamination & Toxicology , 22 :351 , 1992 |
| Abstract : |
| PubMedSearch : Vasilic_1992_Arch.Environ.Contam.Toxicol_22_351 |
| PubMedID: 1375016 |
| Title : Recent advances in cleanup of fats by sweep co-distillation. Part 2. Organophosphorus residues - Luke_1984_J.Assoc.Off.Anal.Chem_67_902 |
| Author(s) : Luke BG , Richards JC |
| Ref : J Assoc Off Analytical Chemistry , 67 :902 , 1984 |
| Abstract : |
| PubMedSearch : Luke_1984_J.Assoc.Off.Anal.Chem_67_902 |
| PubMedID: 6501152 |
| Title : [Effect of temephos on acetylcholinesterase activity in the brain of Tilapia guineensis. 3: Comparative effect of temephos and 3 substitute insecticides] - Pellissier_1983_Toxicol.Eur.Res_5_63 |
| Author(s) : Pellissier C , Leung Tack D , Gras G |
| Ref : Toxicol Eur Res , 5 :63 , 1983 |
| Abstract : |
| PubMedSearch : Pellissier_1983_Toxicol.Eur.Res_5_63 |
| PubMedID: 6193610 |
| Title : Residual toxicity of wall-sprayed organophosphates, carbamates and pyrethroids to mosquito Culex pipiens molestus Forskal - Rettich_1980_J.Hyg.Epidemiol.Microbiol.Immunol_24_110 |
| Author(s) : Rettich F |
| Ref : J Hyg Epidemiol Microbiol Immunol , 24 :110 , 1980 |
| Abstract : |
| PubMedSearch : Rettich_1980_J.Hyg.Epidemiol.Microbiol.Immunol_24_110 |
| PubMedID: 7190586 |
| Title : Dislodgable insecticide residues on cotton foliage: fenvalarate, permethrin, sulprofos, chlorpyrifos, methyl parathion, EPN, oxamyl, and profenofos - |
| Author(s) : Buck NA , Estesen BJ , Ware GW |
| Ref : Bulletin of Environmental Contamination & Toxicology , 24 :283 , 1980 |
| PubMedID: 6153915 |
| Title : Isolation and concentration of organophosphorus pesticides from drinking water at the ng\/L level, using macroreticular resin - LeBel_1979_J.Assoc.Off.Anal.Chem_62_241 |
| Author(s) : LeBel GL , Williams DT , Griffith G , Benoit FM |
| Ref : J Assoc Off Analytical Chemistry , 62 :241 , 1979 |
| Abstract : |
| PubMedSearch : LeBel_1979_J.Assoc.Off.Anal.Chem_62_241 |
| PubMedID: 447594 |
| Title : Detection of O,O-diethyl-O-(2,5-dichlorophenyl) phosphorothioate and O,O-diethyl-O-(3,6-dichloro-2-pyridyl) phosphorothioate in meat fat - Luke_1976_J.Assoc.Off.Anal.Chem_59_1081 |
| Author(s) : Luke BG , Dahl CJ |
| Ref : J Assoc Off Analytical Chemistry , 59 :1081 , 1976 |
| Abstract : |
| PubMedSearch : Luke_1976_J.Assoc.Off.Anal.Chem_59_1081 |
| PubMedID: 61199 |
| Title : Trials with chlorpyrifos (Dursban) as a systemic insecticide against the cattle louse - Loomis_1976_Vet.Rec_98_168 |
| Author(s) : Loomis EC , Lobb PG , Webster AN |
| Ref : Vet Rec , 98 :168 , 1976 |
| Abstract : |
| PubMedSearch : Loomis_1976_Vet.Rec_98_168 |
| PubMedID: 56801 |