Parathion
in vivo metabolized to very toxic compound Paraoxon in which oxygen replaces the sulfur atom
General
Type : Insecticide, Organophosphate, Sulfur Compound, Organothiophosphate, pNP, Derivative of Paraoxon
Chemical_Nomenclature : diethoxy-(4-nitrophenoxy)-sulfanylidene-$l^{5}-phosphane
Canonical SMILES : CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI : InChI=1S\/C10H14NO5PS\/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13\/h5-8H,3-4H2,1-2H3
InChIKey : LCCNCVORNKJIRZ-UHFFFAOYSA-N
Other name(s) : Ethyl parathion || ethylparathion || E605 || Thiophos 3422 || DNTP || Niran || AAT || Etilon || DPP || Paraphos || Alkron || Thiophos || phosphostigmine || Parathion-ethyl || corothion || corthione || danthion || fosfive || fosova || gearphos || genithion || kolphos || kypthion || lirothion || murfos || nourithion || oleoparaphene || oleoparathion || panthion || parathene || pethion || phosphemol || phosphenol || rhodiasol || stathion || strathion || tiofos || vapophos || vitrex || Aphamite || Fosferno || Orthophos || Rhodiatox || Alleron || Folidol || Fostox || Paramar || Parawet || Phoskil || super rodiatox || Aralo || folidol oil || pestox plus || O,O'diethyl O'p-nitrophenylphosphorothionate(or thioate)
MW : 291.3
Formula : C10H14NO5PS
CAS_number : 56-38-2
PubChem : 991
UniChem : LCCNCVORNKJIRZ-UHFFFAOYSA-N
Wikipedia : Parathion
References (48)
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| Author(s) : Gopal S , Rastogi V , Ashman W , Mulbry W |
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| Abstract : |
| PubMedSearch : Gopal_2000_Biochem.Biophys.Res.Commun_279_516 |
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| Title : Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion - Liu_1998_J.Toxicol.Environ.Health_53_531 |
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| Title : Intermediate myasthenia syndrome following acute organophosphates poisoning--an analysis of 21 cases - He_1998_Hum.Exp.Toxicol_17_40 |
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| Abstract : |
| PubMedSearch : He_1998_Hum.Exp.Toxicol_17_40 |
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| Title : Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis - Shih_1998_Nature_394_284 |
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| Title : Learning and memory of rats after long-term administration of low doses of parathion - Ivens_1998_Toxicol.Sci_46_101 |
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| Title : Age-related differences in parathion and chlorpyrifos toxicity in male rats: target and nontarget esterase sensitivity and cytochrome P450- mediated metabolism - Atterberry_1997_Toxicol.Appl.Pharmacol_147_411 |
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| Title : Effects of organophosphate and carbamate pesticides on acetylcholinesterase and choline acetyltransferase activities of the polychaete Nereis diversicolor - Scaps_1997_Arch.Environ.Contam.Toxicol_33_203 |
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| Title : Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning - Worek_1997_Hum.Exp.Toxicol_16_466 |
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| Title : Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons - Rocha_1996_J.Pharmacol.Exp.Ther_278_1175 |
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| Title : Kinetic analysis of the in vitro inhibition, aging, and reactivation of brain acetylcholinesterase from rat and channel catfish by paraoxon and chlorpyrifos-oxon - Carr_1996_Toxicol.Appl.Pharmacol_139_365 |
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| Title : Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae - Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391 |
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| Abstract : |
| PubMedSearch : Pei_1995_Fundam.Appl.Toxicol_28_209 |
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| Title : Use of urinary p-nitrophenol as an index of exposure to parathion - Denga_1995_Bull.Environ.Contam.Toxicol_55_296 |
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| Title : Cytogenetic effects on human lymphocytes of a mixture of fifteen pesticides commonly used in Italy - Dolara_1994_Mutat.Res_325_47 |
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| Title : Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate - Willems_1993_Arch.Toxicol_67_79 |
| Author(s) : Willems JL , De Bisschop HC , Verstraete AG , Declerck C , Christiaens Y , Vanscheeuwyck P , Buylaert WA , Vogelaers D , Colardyn F |
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| Title : Kinetics of the postinhibitory reactions of acetylcholinesterase poisoned by chiral isomalathion: a surprising nonreactivation induced by the RP stereoisomers - Berkman_1993_Chem.Res.Toxicol_6_28 |
| Author(s) : Berkman CE , Ryu S , Quinn DA , Thompson CM |
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| Abstract : |
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| Title : Serum paraoxonase status: a major factor in determining resistance to organophosphates - Li_1993_J.Toxicol.Env.Health_40_337 |
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| Title : Intermediate syndrome in organophosphorus poisoning: a prospective study - De Bleecker_1993_Crit.Care.Med_21_1706 |
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| Title : Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxons in rats - Chambers_1993_Fundam.Appl.Toxicol_21_111 |
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| Title : Correlation of the anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors - Ward_1993_Toxicol.Appl.Pharmacol_122_300 |
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| Title : Percutaneous absorption of organophosphorus insecticides in pigs--the influence of different vehicles - Gyrd-Hansen_1993_J.Vet.Pharmacol.Ther_16_174 |
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| Title : Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet - Dolara_1993_Cell.Biol.Toxicol_9_333 |
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| Title : Down-regulation of muscarinic receptors and the m3 subtype in white-footed mice by dietary exposure to parathion - Jett_1993_J.Toxicol.Environ.Health_39_395 |
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| Title : Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients - Willems_1992_Arch.Toxicol_66_260 |
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| Title : Effects of the organophosphate insecticides diazinon and parathion on bobwhite quail embryos: skeletal defects and acetylcholinesterase activity - Meneely_1989_J.Exp.Zool_252_60 |
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