Parathion
in vivo metabolized to very toxic compound Paraoxon in which oxygen replaces the sulfur atom
General
Type : Insecticide, Organophosphate, Sulfur Compound, Organothiophosphate, pNP, Derivative of Paraoxon
Chemical_Nomenclature : diethoxy-(4-nitrophenoxy)-sulfanylidene-$l^{5}-phosphane
Canonical SMILES : CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI : InChI=1S\/C10H14NO5PS\/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13\/h5-8H,3-4H2,1-2H3
InChIKey : LCCNCVORNKJIRZ-UHFFFAOYSA-N
Other name(s) : Ethyl parathion, ethylparathion, E605, Thiophos 3422, DNTP, Niran, AAT, Etilon, DPP, Paraphos, Alkron, parathion, Thiophos, phosphostigmine, Parathion-ethyl, corothion, corthione, danthion, fosfive, fosova, gearphos, genithion, kolphos, kypthion, lirothion, murfos, nourithion, oleoparaphene, oleoparathion, panthion, parathene, pethion, phosphemol, phosphenol, rhodiasol, stathion, strathion, tiofos, vapophos, vitrex, Aphamite, Fosferno, Orthophos, Rhodiatox, Alleron, Folidol, Fostox, Paramar, Parawet, Phoskil, super rodiatox, Aralo, folidol oil, pestox plus, O,O'diethyl O'p-nitrophenylphosphorothionate(or thioate)
MW : 291.3
Formula : C10H14NO5PS
CAS_number : 56-38-2
PubChem : 991
UniChem : LCCNCVORNKJIRZ-UHFFFAOYSA-N
Wikipedia : Parathion
References (48)
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| PubMedID: 9928630 |
| Title : Learning and memory of rats after long-term administration of low doses of parathion - Ivens_1998_Toxicol.Sci_46_101 |
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| Title : Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion - Liu_1998_J.Toxicol.Environ.Health_53_531 |
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| Title : Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis - Shih_1998_Nature_394_284 |
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| Title : Age-related differences in parathion and chlorpyrifos toxicity in male rats: target and nontarget esterase sensitivity and cytochrome P450- mediated metabolism - Atterberry_1997_Toxicol.Appl.Pharmacol_147_411 |
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| Title : Time course of inhibition of cholinesterase and aliesterase activities, and nonprotein sulfhydryl levels following exposure to organophosphorus insecticides in mosquitofish (Gambusia affinis) - Boone_1996_Fundam.Appl.Toxicol_29_202 |
| Author(s) : Boone JS , Chambers JE |
| Ref : Fundamental & Applied Toxicology , 29 :202 , 1996 |
| PubMedID: 8742317 |
| Title : Kinetic analysis of the in vitro inhibition, aging, and reactivation of brain acetylcholinesterase from rat and channel catfish by paraoxon and chlorpyrifos-oxon - Carr_1996_Toxicol.Appl.Pharmacol_139_365 |
| Author(s) : Carr RL , Chambers JE |
| Ref : Toxicology & Applied Pharmacology , 139 :365 , 1996 |
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| Title : Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae - Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391 |
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| Title : Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons - Rocha_1996_J.Pharmacol.Exp.Ther_278_1175 |
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| Title : Inhibition and aging of channel catfish brain acetylcholinesterase following exposure to two phosphorothionate insecticides and their active metabolites - Carr_1995_J.Toxicol.Env.Health_45_325 |
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| Title : Antagonism of the lethal effects of paraoxon by carrier erythrocytes containing phosphotriesterase - Pei_1995_Fundam.Appl.Toxicol_28_209 |
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| Title : Effect of a mixture of 15 commonly used pesticides on DNA levels of 8- hydroxy-2-deoxyguanosine and xenobiotic metabolizing enzymes in rat liver - Lodovici_1994_J.Environ.Pathol.Toxicol.Oncol_13_163 |
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| PubMedID: 8345567 |
| Title : Down-regulation of muscarinic receptors and the m3 subtype in white-footed mice by dietary exposure to parathion - Jett_1993_J.Toxicol.Environ.Health_39_395 |
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| Title : Serum paraoxonase status: a major factor in determining resistance to organophosphates - Li_1993_J.Toxicol.Env.Health_40_337 |
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| Title : Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxons in rats - Chambers_1993_Fundam.Appl.Toxicol_21_111 |
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| Ref : Fundamental & Applied Toxicology , 21 :111 , 1993 |
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| Title : Intermediate syndrome in organophosphorus poisoning: a prospective study - De Bleecker_1993_Crit.Care.Med_21_1706 |
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| PubMedID: 8222687 |
| Title : Interaction of acetylcholinesterase with the enantiomers of malaoxon and isomalathion - Berkman_1993_Chem.Res.Toxicol_6_724 |
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| Title : Correlation of the anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors - Ward_1993_Toxicol.Appl.Pharmacol_122_300 |
| Author(s) : Ward TR , Ferris DJ , Tilson HA , Mundy WR |
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| Title : Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet - Dolara_1993_Cell.Biol.Toxicol_9_333 |
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| Title : Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate - Willems_1993_Arch.Toxicol_67_79 |
| Author(s) : Willems JL , De Bisschop HC , Verstraete AG , Declerck C , Christiaens Y , Vanscheeuwyck P , Buylaert WA , Vogelaers D , Colardyn F |
| Ref : Archives of Toxicology , 67 :79 , 1993 |
| PubMedID: 8481105 |
| Title : Kinetics of the postinhibitory reactions of acetylcholinesterase poisoned by chiral isomalathion: a surprising nonreactivation induced by the RP stereoisomers - Berkman_1993_Chem.Res.Toxicol_6_28 |
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| Title : Drosophila acetylcholinesterase: characterization of different mutants resistant to insecticides - Pralavorio_1992_Biochem.Genet_30_77 |
| Author(s) : Pralavorio M , Fournier D |
| Ref : Biochemical Genetics , 30 :77 , 1992 |
| PubMedID: 1520255 |
| Title : Parathion transfer and acetylcholinesterase activity in an in-vitro perfused term human placenta - Benjaminov_1992_Vet.Hum.Toxicol_34_10 |
| Author(s) : Benjaminov O , Hoffer E , Taitelman U , Urbach J , Brandes JM |
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| Title : Effects of the organophosphate insecticides diazinon and parathion on bobwhite quail embryos: skeletal defects and acetylcholinesterase activity - Meneely_1989_J.Exp.Zool_252_60 |
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| Title : Brain acetylcholinesterase after acute parathion poisoning: a comparative quantitative histochemical analysis post mortem - Finkelstein_1988_Ann.Neurol_24_252 |
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