Loftus_2005_Nature_433_865

Reference

Title : The genome of the protist parasite Entamoeba histolytica - Loftus_2005_Nature_433_865
Author(s) : Loftus B , Anderson I , Davies R , Alsmark UC , Samuelson J , Amedeo P , Roncaglia P , Berriman M , Hirt RP , Mann BJ , Nozaki T , Suh B , Pop M , Duchene M , Ackers J , Tannich E , Leippe M , Hofer M , Bruchhaus I , Willhoeft U , Bhattacharya A , Chillingworth T , Churcher C , Hance Z , Harris B , Harris D , Jagels K , Moule S , Mungall K , Ormond D , Squares R , Whitehead S , Quail MA , Rabbinowitsch E , Norbertczak H , Price C , Wang Z , Guillen N , Gilchrist C , Stroup SE , Bhattacharya S , Lohia A , Foster PG , Sicheritz-Ponten T , Weber C , Singh U , Mukherjee C , El-Sayed NM , Petri WA, Jr. , Clark CG , Embley TM , Barrell B , Fraser CM , Hall N
Ref : Nature , 433 :865 , 2005
Abstract :

Entamoeba histolytica is an intestinal parasite and the causative agent of amoebiasis, which is a significant source of morbidity and mortality in developing countries. Here we present the genome of E. histolytica, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis. These adaptations include reduction or elimination of most mitochondrial metabolic pathways and the use of oxidative stress enzymes generally associated with anaerobic prokaryotes. Phylogenomic analysis identifies evidence for lateral gene transfer of bacterial genes into the E. histolytica genome, the effects of which centre on expanding aspects of E. histolytica's metabolic repertoire. The presence of these genes and the potential for novel metabolic pathways in E. histolytica may allow for the development of new chemotherapeutic agents. The genome encodes a large number of novel receptor kinases and contains expansions of a variety of gene families, including those associated with virulence. Additional genome features include an abundance of tandemly repeated transfer-RNA-containing arrays, which may have a structural function in the genome. Analysis of the genome provides new insights into the workings and genome evolution of a major human pathogen.

PubMedSearch : Loftus_2005_Nature_433_865
PubMedID: 15729342
Gene_locus related to this paper: entds-b0efg6 , entds-b0egj2 , enthi-b1n4x1 , enthi-b1n449 , enthi-b1n456 , enthi-c4lsp4 , enthi-c4lte6 , enthi-c4lu03 , enthi-c4lu54 , enthi-c4lve4 , enthi-c4lwe1 , enthi-c4m0c3 , enthi-c4m0e4 , enthi-c4m1e7 , enthi-c4m2a9 , enthi-c4m2i4 , enthi-c4m3r1 , enthi-c4m4l3 , enthi-c4m6g0 , enthi-c4m6k3 , enthi-c4m7k7 , enthi-c4m7n4 , enthi-c4m7v0 , enthi-c4m8y5 , enthi-c4m793 , enthi-c4mb48 , enthi-DPP , enthi-q50rh1 , enthi-q50ya6 , enthi-q51a37 , enthi-q51aw6 , enthi-q51ch3 , enthi-q51cz6 , enthi-q51ds3 , enthi-q513q8 , enthi-q513w3 , enthi-q519v1

Related information

Gene_locus entds-b0efg6    entds-b0egj2    enthi-b1n4x1    enthi-b1n449    enthi-b1n456    enthi-c4lsp4    enthi-c4lte6    enthi-c4lu03    enthi-c4lu54    enthi-c4lve4    enthi-c4lwe1    enthi-c4m0c3    enthi-c4m0e4    enthi-c4m1e7    enthi-c4m2a9    enthi-c4m2i4    enthi-c4m3r1    enthi-c4m4l3    enthi-c4m6g0    enthi-c4m6k3    enthi-c4m7k7    enthi-c4m7n4    enthi-c4m7v0    enthi-c4m8y5    enthi-c4m793    enthi-c4mb48    enthi-DPP    enthi-q50rh1    enthi-q50ya6    enthi-q51a37    enthi-q51aw6    enthi-q51ch3    enthi-q51cz6    enthi-q51ds3    enthi-q513q8    enthi-q513w3    enthi-q519v1
Gene_locus_frgt entds-b0efg6    entds-b0egj2    enthi-b1n4x1    enthi-b1n449    enthi-b1n456    enthi-c4lsp4    enthi-c4lte6    enthi-c4lu03    enthi-c4lu54    enthi-c4lve4    enthi-c4lwe1    enthi-c4m0c3    enthi-c4m0e4    enthi-c4m1e7    enthi-c4m2a9    enthi-c4m2i4    enthi-c4m3r1    enthi-c4m4l3    enthi-c4m6g0    enthi-c4m6k3    enthi-c4m7k7    enthi-c4m7n4    enthi-c4m7v0    enthi-c4m8y5    enthi-c4m793    enthi-c4mb48    enthi-DPP    enthi-q50rh1    enthi-q50ya6    enthi-q51a37    enthi-q51aw6    enthi-q51ch3    enthi-q51cz6    enthi-q51ds3    enthi-q513q8    enthi-q513w3    enthi-q519v1    enthi-c4mb54

Citations formats

Loftus B, Anderson I, Davies R, Alsmark UC, Samuelson J, Amedeo P, Roncaglia P, Berriman M, Hirt RP, Mann BJ, Nozaki T, Suh B, Pop M, Duchene M, Ackers J, Tannich E, Leippe M, Hofer M, Bruchhaus I, Willhoeft U, Bhattacharya A, Chillingworth T, Churcher C, Hance Z, Harris B, Harris D, Jagels K, Moule S, Mungall K, Ormond D, Squares R, Whitehead S, Quail MA, Rabbinowitsch E, Norbertczak H, Price C, Wang Z, Guillen N, Gilchrist C, Stroup SE, Bhattacharya S, Lohia A, Foster PG, Sicheritz-Ponten T, Weber C, Singh U, Mukherjee C, El-Sayed NM, Petri WA, Jr., Clark CG, Embley TM, Barrell B, Fraser CM, Hall N (2005)
The genome of the protist parasite Entamoeba histolytica
Nature 433 :865

Loftus B, Anderson I, Davies R, Alsmark UC, Samuelson J, Amedeo P, Roncaglia P, Berriman M, Hirt RP, Mann BJ, Nozaki T, Suh B, Pop M, Duchene M, Ackers J, Tannich E, Leippe M, Hofer M, Bruchhaus I, Willhoeft U, Bhattacharya A, Chillingworth T, Churcher C, Hance Z, Harris B, Harris D, Jagels K, Moule S, Mungall K, Ormond D, Squares R, Whitehead S, Quail MA, Rabbinowitsch E, Norbertczak H, Price C, Wang Z, Guillen N, Gilchrist C, Stroup SE, Bhattacharya S, Lohia A, Foster PG, Sicheritz-Ponten T, Weber C, Singh U, Mukherjee C, El-Sayed NM, Petri WA, Jr., Clark CG, Embley TM, Barrell B, Fraser CM, Hall N (2005)
Nature 433 :865