| Title : Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals - Marco-Contelles_2006_Eur.J.Med.Chem_41_1464 |
| Author(s) : Marco-Contelles J , Leon R , Lopez MG , Garcia AG , Villarroya M |
| Ref : Eur Journal of Medicinal Chemistry , 41 :1464 , 2006 |
|
Abstract :
The synthesis and biological evaluation of ethyl 5-amino-4-(3-pyridyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrano[2,3-b]quinoline-3-car boxylates (9-11) is described. We have found that these compounds inhibit AChE with a mild potency, mitigates the [Ca(2+)](c) triggered by high K(+), and cause neuroprotection against Ca(2+) overloading and free radical-induced neuronal death. |
| PubMedSearch : Marco-Contelles_2006_Eur.J.Med.Chem_41_1464 |
| PubMedID: 17030484 |
Marco-Contelles J, Leon R, Lopez MG, Garcia AG, Villarroya M (2006)
Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals
Eur Journal of Medicinal Chemistry
41 :1464
Marco-Contelles J, Leon R, Lopez MG, Garcia AG, Villarroya M (2006)
Eur Journal of Medicinal Chemistry
41 :1464