Marco-Contelles J

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Title : Studies on the affinity of 6-[(n-(cyclo)aminoalkyl)oxy]-4H-chromen-4-ones for sigma 1\/2 receptors - Deuther-Conrad_2021_RSC.Med.Chem_12_1000
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Title : Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews - Moreta_2021_Biomedicines_9_
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Title : Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments - Bautista-Aguilera_2021_Chem.Rec_21_162
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Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__
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Title : Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy - Bautista-Aguilera_2020_Int.J.Mol.Sci_21_
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Title : Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer's disease therapy - Romero_2020_Neural.Regen.Res_15_30
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Title : Chromenones as Multineurotargeting Inhibitors of Human Enzymes - Lemke_2019_ACS.Omega_4_22161
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Title : Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines - de Los Rios_2019_Eur.J.Med.Chem_166_381
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Title : Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy - Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163
Author(s) : Dgachi Y , Martin H , Malek R , Jun D , Janockova J , Sepsova V , Soukup O , Iriepa I , Moraleda I , Maalej E , Carreiras MC , Refouvelet B , Chabchoub F , Marco-Contelles J , Ismaili L
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Title : Tacrines as Therapeutic Agents for Alzheimer's Disease. IV. The Tacripyrines and Related Annulated Tacrines - Bartolini_2019_Chem.Rec_19_927
Author(s) : Bartolini M , Marco-Contelles J
Ref : Chem Rec , 19 :927 , 2019
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Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416
Author(s) : Malek R , Arribas RL , Palomino-Antolin A , Totoson P , Demougeot C , Kobrlova T , Soukup O , Iriepa I , Moraleda I , Diez-Iriepa D , Godyn J , Panek D , Malawska B , Gluch-Lutwin M , Mordyl B , Siwek A , Chabchoub F , Marco-Contelles J , Kiec-Kononowicz K , Egea J , de los Rios C , Ismaili L
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Title : Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors - Svobodova_2019_Biomolecules_9_
Author(s) : Svobodova B , Mezeiova E , Hepnarova V , Hrabinova M , Muckova L , Kobrlova T , Jun D , Soukup O , Jimeno ML , Marco-Contelles J , Korabecny J
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Title : Synthesis and Biological Evaluation of Novel Chromone+Donepezil Hybrids for Alzheimer's Disease Therapy - Malek_2019_Curr.Alzheimer.Res_16_815
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Title : QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy - Ramos_2019_Molecules_24_
Author(s) : Ramos E , Palomino-Antolin A , Bartolini M , Iriepa I , Moraleda I , Diez-Iriepa D , Samadi A , Cortina CV , Chioua M , Egea J , Romero A , Marco-Contelles J
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Title : Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease - Chioua_2018_Eur.J.Med.Chem_155_839
Author(s) : Chioua M , Buzzi E , Moraleda I , Iriepa I , Maj M , Wnorowski A , Giovannini C , Tramarin A , Portali F , Ismaili L , Lopez-Alvarado P , Bolognesi ML , Jozwiak K , Menendez JC , Marco-Contelles J , Bartolini M
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Title : Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile - Bautista-Aguilera_2018_J.Med.Chem_61_6937
Author(s) : Bautista-Aguilera OM , Budni J , Mina F , Medeiros EB , Deuther-Conrad W , Entrena JM , Moraleda I , Iriepa I , Lopez-Munoz F , Marco-Contelles J
Ref : Journal of Medicinal Chemistry , 61 :6937 , 2018
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Title : Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy - Dgachi_2017_Future.Med.Chem_9_715
Author(s) : Dgachi Y , Martin H , Bonet A , Chioua M , Iriepa I , Moraleda I , Chabchoub F , Marco-Contelles J , Ismaili L
Ref : Future Med Chem , 9 :715 , 2017
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Title : Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease - Ismaili_2017_Prog.Neurobiol_151_4
Author(s) : Ismaili L , Refouvelet B , Benchekroun M , Brogi S , Brindisi M , Gemma S , Campiani G , Filipic S , Agbaba D , Esteban G , Unzeta M , Nikolic K , Butini S , Marco-Contelles J
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Title : New Tacrines as Anti-Alzheimer's Disease Agents. The (Benzo)Chromeno- PyranoTacrines - Oset-Gasque_2017_Curr.Top.Med.Chem_17_3349
Author(s) : Oset-Gasque MJ , Marco-Contelles J
Ref : Curr Top Med Chem , 17 :3349 , 2017
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Title : Recent Developments on Multi-Target-Directed Tacrines for Alzheimer's Disease. I. The Pyranotacrines - Romero_2017_Curr.Top.Med.Chem_17_3328
Author(s) : Romero A , Marco-Contelles J
Ref : Curr Top Med Chem , 17 :3328 , 2017
PubMedID: 29332586

Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765
Author(s) : Bautista-Aguilera OM , Hagenow S , Palomino-Antolin A , Farre-Alins V , Ismaili L , Joffrin PL , Jimeno ML , Soukup O , Janockova J , Kalinowsky L , Proschak E , Iriepa I , Moraleda I , Schwed JS , Romero Martinez A , Lopez-Munoz F , Chioua M , Egea J , Ramsay RR , Marco-Contelles J , Stark H
Ref : Angew Chem Int Ed Engl , 56 :12765 , 2017
PubMedID: 28861918

Title : The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease - Serrano_2017_J.Psychiatry.Neurosci_42_59
Author(s) : Serrano MP , Herrero-Labrador R , Futch HS , Serrano J , Romero A , Fernandez AP , Samadi A , Unzeta M , Marco-Contelles J , Martinez-Murillo R
Ref : J Psychiatry Neurosci , 42 :59 , 2017
PubMedID: 27636528

Title : In-vitro and in-vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system - Esteban_2017_J.Pharm.Pharmacol_69_314
Author(s) : Esteban G , Van Schoors J , Sun P , Van Eeckhaut A , Marco-Contelles J , Smolders I , Unzeta M
Ref : J Pharm Pharmacol , 69 :314 , 2017
PubMedID: 28134992

Title : Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease - Benek_2016_ChemMedChem_11_1264
Author(s) : Benek O , Soukup O , Pasdiorova M , Hroch L , Sepsova V , Jost P , Hrabinova M , Jun D , Kuca K , Zala D , Ramsay RR , Marco-Contelles J , Musilek K
Ref : ChemMedChem , 11 :1264 , 2016
PubMedID: 26427608

Title : Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease - Tommonaro_2016_Eur.J.Med.Chem_122_326
Author(s) : Tommonaro G , Garcia-Font N , Vitale RM , Pejin B , Iodice C , Canadas S , Marco-Contelles J , Oset-Gasque MJ
Ref : Eur Journal of Medicinal Chemistry , 122 :326 , 2016
PubMedID: 27376495

Title : Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation - Wu_2016_Eur.J.Med.Chem_121_864
Author(s) : Wu MY , Esteban G , Brogi S , Shionoya M , Wang L , Campiani G , Unzeta M , Inokuchi T , Butini S , Marco-Contelles J
Ref : Eur Journal of Medicinal Chemistry , 121 :864 , 2016
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Title : Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy - Dgachi_2016_Eur.J.Med.Chem_126_576
Author(s) : Dgachi Y , Sokolov O , Luzet V , Godyn J , Panek D , Bonet A , Martin H , Iriepa I , Moraleda I , Garcia-Iriepa C , Janockova J , Richert L , Soukup O , Malawska B , Chabchoub F , Marco-Contelles J , Ismaili L
Ref : Eur Journal of Medicinal Chemistry , 126 :576 , 2016
PubMedID: 27918993

Title : Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease - Unzeta_2016_Front.Neurosci_10_205
Author(s) : Unzeta M , Esteban G , Bolea I , Fogel WA , Ramsay RR , Youdim MB , Tipton KF , Marco-Contelles J
Ref : Front Neurosci , 10 :205 , 2016
PubMedID: 27252617

Title : The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators - Benchekroun_2016_J.Med.Chem_59_9967
Author(s) : Benchekroun M , Romero A , Egea J , Leon R , Michalska P , Buendia I , Jimeno ML , Jun D , Janockova J , Sepsova V , Soukup O , Bautista-Aguilera OM , Refouvelet B , Ouari O , Marco-Contelles J , Ismaili L
Ref : Journal of Medicinal Chemistry , 59 :9967 , 2016
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Title : Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Abeta1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy - Dgachi_2016_ChemMedChem_11_1318
Author(s) : Dgachi Y , Ismaili L , Knez D , Benchekroun M , Martin H , Szalaj N , Wehle S , Bautista-Aguilera OM , Luzet V , Bonnet A , Malawska B , Gobec S , Chioua M , Decker M , Chabchoub F , Marco-Contelles J
Ref : ChemMedChem , 11 :1318 , 2016
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Title : Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy - Boulebd_2016_Molecules_21_
Author(s) : Boulebd H , Ismaili L , Bartolini M , Bouraiou A , Andrisano V , Martin H , Bonet A , Moraleda I , Iriepa I , Chioua M , Belfaitah A , Marco-Contelles J
Ref : Molecules , 21 : , 2016
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Title : ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy - Marco-Contelles_2016_Front.Neurosci_10_294
Author(s) : Marco-Contelles J , Unzeta M , Bolea I , Esteban G , Ramsay RR , Romero A , Martinez-Murillo R , Carreiras MC , Ismaili L
Ref : Front Neurosci , 10 :294 , 2016
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Title : Upregulation of Antioxidant Enzymes by ASS234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy -
Author(s) : Ramos E , Romero A , Marco-Contelles J , Del Pino J
Ref : CNS Neurosci Ther , 22 :799 , 2016
PubMedID: 27380946

Title : Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease - Dgachi_2016_Molecules_21_
Author(s) : Dgachi Y , Bautista-Aguilera OM , Benchekroun M , Martin H , Bonet A , Knez D , Godyn J , Malawska B , Gobec S , Chioua M , Janockova J , Soukup O , Chabchoub F , Marco-Contelles J , Ismaili L
Ref : Molecules , 21 : , 2016
PubMedID: 27187348

Title : Purine homo-N-nucleoside+coumarin hybrids as pleiotropic agents for the potential treatment of Alzheimer's disease - Kallitsakis_2015_Future.Med.Chem_7_103
Author(s) : Kallitsakis MG , Yanez M , Soriano E , Marco-Contelles J , Hadjipavlou-Litina DJ , Litinas KE
Ref : Future Med Chem , 7 :103 , 2015
PubMedID: 25686000

Title : Donepezil-ferulic acid hybrids as anti-Alzheimer drugs - Benchekroun_2015_Future.Med.Chem_7_15
Author(s) : Benchekroun M , Ismaili L , Pudlo M , Luzet V , Gharbi T , Refouvelet B , Marco-Contelles J
Ref : Future Med Chem , 7 :15 , 2015
PubMedID: 25582330

Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523
Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L
Ref : ChemMedChem , 10 :523 , 2015
PubMedID: 25537267

Title : Predicting targets of compounds against neurological diseases using cheminformatic methodology - Nikolic_2015_J.Comput.Aided.Mol.Des_29_183
Author(s) : Nikolic K , Mavridis L , Bautista-Aguilera OM , Marco-Contelles J , Stark H , do Carmo Carreiras M , Rossi I , Massarelli P , Agbaba D , Ramsay RR , Mitchell JB
Ref : J Comput Aided Mol Des , 29 :183 , 2015
PubMedID: 25425329

Title : Pyranopyrazolotacrines as nonneurotoxic, Abeta-anti-aggregating and neuroprotective agents for Alzheimer's disease - Chioua_2015_Future.Med.Chem_7_845
Author(s) : Chioua M , Perez-Pena J , Garcia-Font N , Moraleda I , Iriepa I , Soriano E , Marco-Contelles J , Oset-Gasque MJ
Ref : Future Med Chem , 7 :845 , 2015
PubMedID: 26061104

Title : Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease - Wang_2014_Eur.J.Med.Chem_80_543
Author(s) : Wang L , Esteban G , Ojima M , Bautista-Aguilera OM , Inokuchi T , Moraleda I , Iriepa I , Samadi A , Youdim MB , Romero A , Soriano E , Herrero R , Fernandez Fernandez AP , Ricardo Martinez M , Marco-Contelles J , Unzeta M
Ref : Eur Journal of Medicinal Chemistry , 80 :543 , 2014
PubMedID: 24813882

Title : Multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids - Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893
Author(s) : Bautista-Aguilera OM , Esteban G , Chioua M , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Soriano E , Samadi A , Unzeta M , Marco-Contelles J
Ref : Drug Des Devel Ther , 8 :1893 , 2014
PubMedID: 25378907

Title : Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase\/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease - Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82
Author(s) : Bautista-Aguilera OM , Esteban G , Bolea I , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Samadi A , Soriano E , Unzeta M , Marco-Contelles J
Ref : Eur Journal of Medicinal Chemistry , 75C :82 , 2014
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Title : Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease - Esteban_2014_Biochim.Biophys.Acta_1844_1104
Author(s) : Esteban G , Allan J , Samadi A , Mattevi A , Unzeta M , Marco-Contelles J , Binda C , Ramsay RR
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Title : Wnt signaling pathway, a potential target for Alzheimer's disease treatment, is activated by a novel multitarget compound ASS234 -
Author(s) : Del Pino J , Ramos E , Aguilera OM , Marco-Contelles J , Romero A
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Title : Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia - Stasiak_2014_Curr.Pharm.Des_20_161
Author(s) : Stasiak A , Mussur M , Unzeta M , Samadi A , Marco-Contelles JL , Fogel WA , Marco-Contelles J
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Title : N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2- yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor - Bautista-Aguilera_2014_J.Med.Chem_57_10455
Author(s) : Bautista-Aguilera OM , Samadi A , Chioua M , Nikolic K , Filipic S , Agbaba D , Soriano E , de Andres L , Rodriguez-Franco MI , Alcaro S , Ramsay RR , Ortuso F , Yanez M , Marco-Contelles J
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Title : Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease - Cherif_2014_Future.Med.Chem_6_1883
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PubMedID: 25495982

Title : The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon - Rosini_2013_ChemMedChem_8_1276
Author(s) : Rosini M , Simoni E , Bartolini M , Soriano E , Marco-Contelles J , Andrisano V , Monti B , Windisch M , Hutter-Paier B , McClymont DW , Mellor IR , Bolognesi ML
Ref : ChemMedChem , 8 :1276 , 2013
PubMedID: 23824986

Title : A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BCHE - Esteban_2013_J.Neural.Transm_120_911
Author(s) : Esteban G , Bolea I , Sun P , Sole M , Samadi A , Marco-Contelles J , Unzeta M
Ref : J Neural Transm , 120 :911 , 2013
PubMedID: 23263540

Title : Nontoxic and neuroprotective beta-naphthotacrines for Alzheimer's disease - Esquivias-Perez_2013_Chem.Res.Toxicol_26_986
Author(s) : Esquivias-Perez M , Maalej E , Romero A , Chabchoub F , Samadi A , Marco-Contelles J , Oset-Gasque MJ
Ref : Chemical Research in Toxicology , 26 :986 , 2013
PubMedID: 23676090

Title : The multifactorial nature of Alzheimer's disease for developing potential therapeutics - Carreiras_2013_Curr.Top.Med.Chem_13_1745
Author(s) : Carreiras MC , Mendes E , Perry MJ , Francisco AP , Marco-Contelles J
Ref : Curr Top Med Chem , 13 :1745 , 2013
PubMedID: 23931435

Title : PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice - Lorrio_2013_ACS.Chem.Neurosci_4_1267
Author(s) : Lorrio S , Romero A , Gonzalez-Lafuente L , Lajarin-Cuesta R , Martinez-Sanz FJ , Estrada M , Samadi A , Marco-Contelles J , Rodriguez-Franco MI , Villarroya M , Lopez MG , de los Rios C
Ref : ACS Chem Neurosci , 4 :1267 , 2013
PubMedID: 23763493

Title : Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2013_Eur.J.Med.Chem_67_64
Author(s) : Samadi A , de la Fuente Revenga M , Perez C , Iriepa I , Moraleda I , Rodriguez-Franco MI , Marco-Contelles J
Ref : Eur Journal of Medicinal Chemistry , 67 :64 , 2013
PubMedID: 23838422

Title : Multipotent, permeable drug ASS234 inhibits Abeta aggregation, possesses antioxidant properties and protects from Abeta-induced apoptosis in vitro - Bolea_2013_Curr.Alzheimer.Res_10_797
Author(s) : Bolea I , Gella A , Monjas L , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Samadi A , Unzeta M
Ref : Curr Alzheimer Res , 10 :797 , 2013
PubMedID: 23919774

Title : Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase\/butyrylcholinesterase inhibitors: effect against amyloid-beta-induced neurotoxicity - Silva_2013_ACS.Chem.Neurosci_4_547
Author(s) : Silva D , Chioua M , Samadi A , Agostinho P , Garcao P , Lajarin-Cuesta R , de los Rios C , Iriepa I , Moraleda I , Gonzalez-Lafuente L , Mendes E , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Carmo Carreiras M
Ref : ACS Chem Neurosci , 4 :547 , 2013
PubMedID: 23379636

Title : Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine - Samadi_2012_Eur.J.Med.Chem_52_251
Author(s) : Samadi A , de los Rios C , Bolea I , Chioua M , Iriepa I , Moraleda I , Bartolini M , Andrisano V , Galvez E , Valderas C , Unzeta M , Marco-Contelles J
Ref : Eur Journal of Medicinal Chemistry , 52 :251 , 2012
PubMedID: 22503231

Title : Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling - Samadi_2012_Eur.J.Med.Chem_57C_296
Author(s) : Samadi A , Estrada M , Perez C , Rodriguez-Franco MI , Iriepa I , Moraleda I , Chioua M , Marco-Contelles J
Ref : Eur Journal of Medicinal Chemistry , 57C :296 , 2012
PubMedID: 23078965

Title : Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives - Silva_2011_Eur.J.Med.Chem_46_4676
Author(s) : Silva D , Chioua M , Samadi A , Carmo Carreiras M , Jimeno ML , Mendes E , Rios Cde L , Romero A , Villarroya M , Lopez MG , Marco-Contelles J
Ref : Eur Journal of Medicinal Chemistry , 46 :4676 , 2011
PubMedID: 21715067

Title : Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists - Tomassoli_2011_Eur.J.Med.Chem_46_1
Author(s) : Tomassoli I , Ismaili L , Pudlo M , de los Rios C , Soriano E , Colmena I , Gandia L , Rivas L , Samadi A , Marco-Contelles J , Refouvelet B
Ref : Eur Journal of Medicinal Chemistry , 46 :1 , 2011
PubMedID: 21111515

Title : Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues - Martins_2011_Eur.J.Med.Chem_46_6119
Author(s) : Martins C , Carreiras MC , Leon R , de los Rios C , Bartolini M , Andrisano V , Iriepa I , Moraleda I , Galvez E , Garcia M , Egea J , Samadi A , Chioua M , Marco-Contelles J
Ref : Eur Journal of Medicinal Chemistry , 46 :6119 , 2011
PubMedID: 22000936

Title : Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2011_Eur.J.Med.Chem_46_4665
Author(s) : Samadi A , Chioua M , Bolea I , de los Rios C , Iriepa I , Moraleda I , Bastida A , Esteban G , Unzeta M , Galvez E , Marco-Contelles J
Ref : Eur Journal of Medicinal Chemistry , 46 :4665 , 2011
PubMedID: 21669479

Title : Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity - Pereira_2011_Eur.J.Pharmacol_660_411
Author(s) : Pereira JD , Caricati-Neto A , Miranda-Ferreira R , Smaili SS , Godinho RO , de los Rios C , Leon R , Villaroya M , Samadi A , Marco-Contelles J , Jurkiewicz NH , Garcia AG , Jurkiewicz A
Ref : European Journal of Pharmacology , 660 :411 , 2011
PubMedID: 21497158

Title : Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease - Bolea_2011_J.Med.Chem_54_8251
Author(s) : Bolea I , Juarez-Jimenez J , de los Rios C , Chioua M , Pouplana R , Luque FJ , Unzeta M , Marco-Contelles J , Samadi A
Ref : Journal of Medicinal Chemistry , 54 :8251 , 2011
PubMedID: 22023459

Title : Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines - Maalej_2011_Bioorg.Med.Chem.Lett_21_2384
Author(s) : Maalej E , Chabchoub F , Samadi A , de los Rios C , Perona A , Morreale A , Marco-Contelles J
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2384 , 2011
PubMedID: 21411323

Title : Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate - Soriano_2010_Bioorg.Med.Chem.Lett_20_2950
Author(s) : Soriano E , Samadi A , Chioua M , de los Rios C , Marco-Contelles J
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2950 , 2010
PubMedID: 20350807

Title : Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives - de Los Rios_2010_J.Med.Chem_53_5129
Author(s) : de los Rios C , Egea J , Marco-Contelles J , Leon R , Samadi A , Iriepa I , Moraleda I , Galvez E , Garcia AG , Lopez MG , Villarroya M , Romero A
Ref : Journal of Medicinal Chemistry , 53 :5129 , 2010
PubMedID: 20575555

Title : Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles - Samadi_2010_Bioorg.Med.Chem_18_5861
Author(s) : Samadi A , Marco-Contelles J , Soriano E , Alvarez-Perez M , Chioua M , Romero A , Gonzalez-Lafuente L , Gandia L , Roda JM , Lopez MG , Villarroya M , Garcia AG , Rios Cde L
Ref : Bioorganic & Medicinal Chemistry , 18 :5861 , 2010
PubMedID: 20656495

Title : New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties - Leon_2008_Bioorg.Med.Chem_16_7759
Author(s) : Leon R , de los Rios C , Marco-Contelles J , Huertas O , Barril X , Luque FJ , Lopez MG , Garcia AG , Villarroya M
Ref : Bioorganic & Medicinal Chemistry , 16 :7759 , 2008
PubMedID: 18640842

Title : An update on the pharmacology of galantamine - Villarroya_2007_Expert.Opin.Investig.Drugs_16_1987
Author(s) : Villarroya M , Garcia AG , Marco-Contelles J , Lopez MG
Ref : Expert Opin Investig Drugs , 16 :1987 , 2007
PubMedID: 18042006

Title : Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease - Marco-Contelles_2006_J.Med.Chem_49_7607
Author(s) : Marco-Contelles J , Leon R , de los Rios C , Guglietta A , Terencio J , Lopez MG , Garcia AG , Villarroya M
Ref : Journal of Medicinal Chemistry , 49 :7607 , 2006
PubMedID: 17181144

Title : Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals - Marco-Contelles_2006_Eur.J.Med.Chem_41_1464
Author(s) : Marco-Contelles J , Leon R , Lopez MG , Garcia AG , Villarroya M
Ref : Eur Journal of Medicinal Chemistry , 41 :1464 , 2006
PubMedID: 17030484

Title : Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues - Leon_2005_Bioorg.Med.Chem_13_1167
Author(s) : Leon R , Marco-Contelles J , Garcia AG , Villarroya M
Ref : Bioorganic & Medicinal Chemistry , 13 :1167 , 2005
PubMedID: 15670925