| Title : Awareness of national dementia guidelines and management of oldest-old and frail people living with dementia: a European survey of geriatricians - De Bondt_2025_Eur.Geriatr.Med__ |
| Author(s) : De Bondt E , Locquet P , Lopez MG , Soysal P , Welsh T , Shenkin SD , Tournoy J |
| Ref : Eur Geriatr Med , : , 2025 |
| Abstract : |
| PubMedSearch : De Bondt_2025_Eur.Geriatr.Med__ |
| PubMedID: 39979530 |
| Title : Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer's Disease - Michalska_2020_Antioxidants.(Basel)_9_ |
| Author(s) : Michalska P , Mayo P , Fernandez-Mendivil C , Tenti G , Duarte P , Buendia I , Ramos MT , Lopez MG , Menendez JC , Leon R |
| Ref : Antioxidants (Basel) , 9 : , 2020 |
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| PubMedSearch : Michalska_2020_Antioxidants.(Basel)_9_ |
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| Title : Neuroprotective activity of isoquinoline alkaloids from of Chilean Amaryllidaceae plants against oxidative stress-induced cytotoxicity on human neuroblastoma SH-SY5Y cells and mouse hippocampal slice culture - Trujillo-Chacon_2019_Food.Chem.Toxicol_132_110665 |
| Author(s) : Trujillo-Chacon LM , Alarcon-Enos JE , Cespedes-Acuna CL , Bustamante L , Baeza M , Lopez MG , Fernandez-Mendivil C , Cabezas F , Pastene-Navarrete ER |
| Ref : Food & Chemical Toxicology , 132 :110665 , 2019 |
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| PubMedSearch : Trujillo-Chacon_2019_Food.Chem.Toxicol_132_110665 |
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| Title : Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia - Monjas_2017_Eur.J.Med.Chem_130_60 |
| Author(s) : Monjas L , Arce MP , Leon R , Egea J , Perez C , Villarroya M , Lopez MG , Gil C , Conde S , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 130 :60 , 2017 |
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| PubMedSearch : Monjas_2017_Eur.J.Med.Chem_130_60 |
| PubMedID: 28242552 |
| Title : Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography - Zha_2016_J.Med.Chem_59_114 |
| Author(s) : Zha X , Lamba D , Zhang L , Lou Y , Xu C , Kang D , Chen L , Xu Y , De Simone A , Samez S , Pesaresi A , Stojan J , Lopez MG , Egea J , Andrisano V , Bartolini M |
| Ref : Journal of Medicinal Chemistry , 59 :114 , 2016 |
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| PubMedSearch : Zha_2016_J.Med.Chem_59_114 |
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| Gene_locus related to this paper: torca-ACHE |
| Title : Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures - Buendia_2016_Mol.Neurobiol_53_3338 |
| Author(s) : Buendia I , Parada E , Navarro E , Leon R , Negredo P , Egea J , Lopez MG |
| Ref : Molecular Neurobiology , 53 :3338 , 2016 |
| Abstract : |
| PubMedSearch : Buendia_2016_Mol.Neurobiol_53_3338 |
| PubMedID: 26081146 |
| Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523 |
| Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L |
| Ref : ChemMedChem , 10 :523 , 2015 |
| Abstract : |
| PubMedSearch : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedID: 25537267 |
| Title : Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection - Egea_2015_Biochem.Pharmacol_97(4)_463 |
| Author(s) : Egea J , Buendia I , Parada E , Navarro E , Leon R , Lopez MG |
| Ref : Biochemical Pharmacology , 97 :463 , 2015 |
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| PubMedSearch : Egea_2015_Biochem.Pharmacol_97(4)_463 |
| PubMedID: 26232730 |
| Title : Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction - Navarro_2015_Biochem.Pharmacol_97(4)_473 |
| Author(s) : Navarro E , Buendia I , Parada E , Leon R , Jansen-Duerr P , Pircher H , Egea J , Lopez MG |
| Ref : Biochemical Pharmacology , 97 :473 , 2015 |
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| PubMedSearch : Navarro_2015_Biochem.Pharmacol_97(4)_473 |
| PubMedID: 26212551 |
| Title : Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease - Cherif_2014_Future.Med.Chem_6_1883 |
| Author(s) : Cherif O , Allouche F , Chabchoub F , Chioua M , Soriano E , Yanez M , Cacabelos R , Romero A , Lopez MG , Marco-Contelles J |
| Ref : Future Med Chem , 6 :1883 , 2014 |
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| PubMedSearch : Cherif_2014_Future.Med.Chem_6_1883 |
| PubMedID: 25495982 |
| Title : Chalcones as positive allosteric modulators of alpha7 nicotinic acetylcholine receptors: a new target for a privileged structure - Balsera_2014_Eur.J.Med.Chem_86_724 |
| Author(s) : Balsera B , Mulet J , Fernandez-Carvajal A , de la Torre-Martinez R , Ferrer-Montiel A , Hernandez-Jimenez JG , Estevez-Herrera J , Borges R , Freitas AE , Lopez MG , Garcia-Lopez MT , Gonzalez-Muniz R , Perez de Vega MJ , Valor LM , Svobodova L , Sala S , Sala F , Criado M |
| Ref : Eur Journal of Medicinal Chemistry , 86 :724 , 2014 |
| Abstract : |
| PubMedSearch : Balsera_2014_Eur.J.Med.Chem_86_724 |
| PubMedID: 25232969 |
| Title : New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease - Lopez-Iglesias_2014_J.Med.Chem_57_3773 |
| Author(s) : Lopez-Iglesias B , Perez C , Morales-Garcia JA , Alonso-Gil S , Perez-Castillo A , Romero A , Lopez MG , Villarroya M , Conde S , Rodriguez-Franco MI |
| Ref : Journal of Medicinal Chemistry , 57 :3773 , 2014 |
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| PubMedSearch : Lopez-Iglesias_2014_J.Med.Chem_57_3773 |
| PubMedID: 24738476 |
| Title : PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice - Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| Author(s) : Lorrio S , Romero A , Gonzalez-Lafuente L , Lajarin-Cuesta R , Martinez-Sanz FJ , Estrada M , Samadi A , Marco-Contelles J , Rodriguez-Franco MI , Villarroya M , Lopez MG , de los Rios C |
| Ref : ACS Chem Neurosci , 4 :1267 , 2013 |
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| PubMedSearch : Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| PubMedID: 23763493 |
| Title : Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by alpha7 and beta2* nicotinic stimulation - Del Barrio_2011_Toxicol.Sci_123_193 |
| Author(s) : Del Barrio L , Martin-de-Saavedra MD , Romero A , Parada E , Egea J , Avila J , McIntosh JM , Wonnacott S , Lopez MG |
| Ref : Toxicol Sci , 123 :193 , 2011 |
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| PubMedSearch : Del Barrio_2011_Toxicol.Sci_123_193 |
| PubMedID: 21715663 |
| Title : N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease - Gonzalez-Munoz_2011_Eur.J.Med.Chem_46_2224 |
| Author(s) : Gonzalez-Munoz GC , Arce MP , Lopez B , Perez C , Romero A , Del Barrio L , Martin-de-Saavedra MD , Egea J , Leon R , Villarroya M , Lopez MG , Garcia AG , Conde S , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 46 :2224 , 2011 |
| Abstract : |
| PubMedSearch : Gonzalez-Munoz_2011_Eur.J.Med.Chem_46_2224 |
| PubMedID: 21420206 |
| Title : Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives - Silva_2011_Eur.J.Med.Chem_46_4676 |
| Author(s) : Silva D , Chioua M , Samadi A , Carmo Carreiras M , Jimeno ML , Mendes E , Rios Cde L , Romero A , Villarroya M , Lopez MG , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :4676 , 2011 |
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| PubMedSearch : Silva_2011_Eur.J.Med.Chem_46_4676 |
| PubMedID: 21715067 |
| Title : Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease - |
| Author(s) : Bartolini M , Pistolozzi M , Andrisano V , Egea J , Lopez MG , Iriepa I , Moraleda I , Galvez E , Marco-Contelles J , Samadi A |
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| Title : Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives - de Los Rios_2010_J.Med.Chem_53_5129 |
| Author(s) : de los Rios C , Egea J , Marco-Contelles J , Leon R , Samadi A , Iriepa I , Moraleda I , Galvez E , Garcia AG , Lopez MG , Villarroya M , Romero A |
| Ref : Journal of Medicinal Chemistry , 53 :5129 , 2010 |
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| PubMedSearch : de Los Rios_2010_J.Med.Chem_53_5129 |
| PubMedID: 20575555 |
| Title : Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties - Fernandez-Bachiller_2010_J.Med.Chem_53_4927 |
| Author(s) : Fernandez-Bachiller MI , Perez C , Gonzalez-Munoz GC , Conde S , Lopez MG , Villarroya M , Garcia AG , Rodriguez-Franco MI |
| Ref : Journal of Medicinal Chemistry , 53 :4927 , 2010 |
| Abstract : |
| PubMedSearch : Fernandez-Bachiller_2010_J.Med.Chem_53_4927 |
| PubMedID: 20545360 |
| Title : Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells - Romero_2010_J.Pineal.Res_49_141 |
| Author(s) : Romero A , Egea J , Garcia AG , Lopez MG |
| Ref : J Pineal Res , 49 :141 , 2010 |
| Abstract : |
| PubMedSearch : Romero_2010_J.Pineal.Res_49_141 |
| PubMedID: 20536682 |
| Title : Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases - Gonzalez-Munoz_2010_Eur.J.Med.Chem_45_6152 |
| Author(s) : Gonzalez-Munoz GC , Arce MP , Lopez B , Perez C , Villarroya M , Lopez MG , Garcia AG , Conde S , Rodriguez-Franco MI |
| Ref : Eur Journal of Medicinal Chemistry , 45 :6152 , 2010 |
| Abstract : |
| PubMedSearch : Gonzalez-Munoz_2010_Eur.J.Med.Chem_45_6152 |
| PubMedID: 20926162 |
| Title : Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles - Samadi_2010_Bioorg.Med.Chem_18_5861 |
| Author(s) : Samadi A , Marco-Contelles J , Soriano E , Alvarez-Perez M , Chioua M , Romero A , Gonzalez-Lafuente L , Gandia L , Roda JM , Lopez MG , Villarroya M , Garcia AG , Rios Cde L |
| Ref : Bioorganic & Medicinal Chemistry , 18 :5861 , 2010 |
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| PubMedSearch : Samadi_2010_Bioorg.Med.Chem_18_5861 |
| PubMedID: 20656495 |
| Title : Effects of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils - Lorrio_2009_Brain.Res_1254_128 |
| Author(s) : Lorrio S , Negredo P , Roda JM , Garcia AG , Lopez MG |
| Ref : Brain Research , 1254 :128 , 2009 |
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| PubMedSearch : Lorrio_2009_Brain.Res_1254_128 |
| PubMedID: 19103181 |
| Title : Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease - Arce_2009_J.Med.Chem_52_7249 |
| Author(s) : Arce MP , Rodriguez-Franco MI , Gonzalez-Munoz GC , Perez C , Lopez B , Villarroya M , Lopez MG , Garcia AG , Conde S |
| Ref : Journal of Medicinal Chemistry , 52 :7249 , 2009 |
| Abstract : |
| PubMedSearch : Arce_2009_J.Med.Chem_52_7249 |
| PubMedID: 19856923 |
| Title : Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease - Marco-Contelles_2009_J.Med.Chem_52_2724 |
| Author(s) : Marco-Contelles J , Leon R , de los Rios C , Samadi A , Bartolini M , Andrisano V , Huertas O , Barril X , Luque FJ , Rodriguez-Franco MI , Lopez B , Lopez MG , Garcia AG , Carreiras Mdo C , Villarroya M |
| Ref : Journal of Medicinal Chemistry , 52 :2724 , 2009 |
| Abstract : |
| PubMedSearch : Marco-Contelles_2009_J.Med.Chem_52_2724 |
| PubMedID: 19374444 |
| Title : Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties - Fernandez-Bachiller_2009_ChemMedChem_4_828 |
| Author(s) : Fernandez-Bachiller MI , Perez C , Campillo NE , Paez JA , Gonzalez-Munoz GC , Usan P , Garcia-Palomero E , Lopez MG , Villarroya M , Garcia AG , Martinez A , Rodriguez-Franco MI |
| Ref : ChemMedChem , 4 :828 , 2009 |
| Abstract : |
| PubMedSearch : Fernandez-Bachiller_2009_ChemMedChem_4_828 |
| PubMedID: 19308922 |
| Title : New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties - Leon_2008_Bioorg.Med.Chem_16_7759 |
| Author(s) : Leon R , de los Rios C , Marco-Contelles J , Huertas O , Barril X , Luque FJ , Lopez MG , Garcia AG , Villarroya M |
| Ref : Bioorganic & Medicinal Chemistry , 16 :7759 , 2008 |
| Abstract : |
| PubMedSearch : Leon_2008_Bioorg.Med.Chem_16_7759 |
| PubMedID: 18640842 |
| Title : An update on the pharmacology of galantamine - Villarroya_2007_Expert.Opin.Investig.Drugs_16_1987 |
| Author(s) : Villarroya M , Garcia AG , Marco-Contelles J , Lopez MG |
| Ref : Expert Opin Investig Drugs , 16 :1987 , 2007 |
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| PubMedSearch : Villarroya_2007_Expert.Opin.Investig.Drugs_16_1987 |
| PubMedID: 18042006 |
| Title : Desensitized nicotinic receptors that, however, afford cytoprotection in bovine chromaffin cells - Egea_2006_J.Mol.Neurosci_30_59 |
| Author(s) : Egea J , Hernandez-Guijo JM , Olivares R , Lopez MG , Garcia AG |
| Ref : Journal of Molecular Neuroscience , 30 :59 , 2006 |
| Abstract : |
| PubMedSearch : Egea_2006_J.Mol.Neurosci_30_59 |
| PubMedID: 17192627 |
| Title : Can cholinesterase inhibitors provide additional effects to cholinergic neurotransmission enhancement? - Lopez_2006_J.Mol.Neurosci_30_141 |
| Author(s) : Lopez MG , Arias E , Sobrado M , Lorrio S , Roda JM , Garcia AG |
| Ref : Journal of Molecular Neuroscience , 30 :141 , 2006 |
| Abstract : |
| PubMedSearch : Lopez_2006_J.Mol.Neurosci_30_141 |
| PubMedID: 17192661 |
| Title : Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: involvement of the alpha7 nAChR subtype - Rosa_2006_J.Mol.Neurosci_30_61 |
| Author(s) : Rosa AO , Egea J , Gandia L , Lopez MG , Garcia AG |
| Ref : Journal of Molecular Neuroscience , 30 :61 , 2006 |
| Abstract : |
| PubMedSearch : Rosa_2006_J.Mol.Neurosci_30_61 |
| PubMedID: 17192628 |
| Title : Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals - Marco-Contelles_2006_Eur.J.Med.Chem_41_1464 |
| Author(s) : Marco-Contelles J , Leon R , Lopez MG , Garcia AG , Villarroya M |
| Ref : Eur Journal of Medicinal Chemistry , 41 :1464 , 2006 |
| Abstract : |
| PubMedSearch : Marco-Contelles_2006_Eur.J.Med.Chem_41_1464 |
| PubMedID: 17030484 |
| Title : Blockade of Ca2+ -activated K+ channels by galantamine can also contribute to the potentiation of catecholamine secretion from chromaffin cells - Ales_2006_Eur.J.Pharmacol_548_45 |
| Author(s) : Ales E , Gullo F , Arias E , Olivares R , Garcia AG , Wanke E , Lopez MG |
| Ref : European Journal of Pharmacology , 548 :45 , 2006 |
| Abstract : |
| PubMedSearch : Ales_2006_Eur.J.Pharmacol_548_45 |
| PubMedID: 16949070 |
| Title : Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease - Marco-Contelles_2006_J.Med.Chem_49_7607 |
| Author(s) : Marco-Contelles J , Leon R , de los Rios C , Guglietta A , Terencio J , Lopez MG , Garcia AG , Villarroya M |
| Ref : Journal of Medicinal Chemistry , 49 :7607 , 2006 |
| Abstract : |
| PubMedSearch : Marco-Contelles_2006_J.Med.Chem_49_7607 |
| PubMedID: 17181144 |
| Title : Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors - Arias_2005_J.Pharmacol.Exp.Ther_315_1346 |
| Author(s) : Arias E , Gallego-Sandin S , Villarroya M , Garcia AG , Lopez MG |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 315 :1346 , 2005 |
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| PubMedSearch : Arias_2005_J.Pharmacol.Exp.Ther_315_1346 |
| PubMedID: 16144975 |
| Title : Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation - Sobrado_2004_Neurosci.Lett_365_132 |
| Author(s) : Sobrado M , Roda JM , Lopez MG , Egea J , Garcia AG |
| Ref : Neuroscience Letters , 365 :132 , 2004 |
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| PubMedSearch : Sobrado_2004_Neurosci.Lett_365_132 |
| PubMedID: 15245794 |
| Title : Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors - Arias_2004_Neuropharmacol_46_103 |
| Author(s) : Arias E , Ales E , Gabilan NH , Cano-Abad MF , Villarroya M , Garcia AG , Lopez MG |
| Ref : Neuropharmacology , 46 :103 , 2004 |
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| PubMedSearch : Arias_2004_Neuropharmacol_46_103 |
| PubMedID: 14654102 |
| Title : ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylat e), a novel acetylcholinesterase inhibitor with calcium promotor and neuroprotective properties - Orozco_2004_J.Pharmacol.Exp.Ther_310_987 |
| Author(s) : Orozco C , de los Rios C , Arias E , Leon R , Garcia AG , Marco JL , Villarroya M , Lopez MG |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 310 :987 , 2004 |
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| PubMedSearch : Orozco_2004_J.Pharmacol.Exp.Ther_310_987 |
| PubMedID: 15111641 |